Tumor Biol. DOI 10.1007/s13277-014-2943-4
RESEARCH ARTICLE
Downregulation of Kruppel-like factor 2 is associated with poor prognosis for nonsmall-cell lung cancer Li Yin & Ji-peng Wang & Tong-peng Xu & Wen-ming Chen & Ming-de Huang & Rui Xia & Xin-xin Liu & Rong Kong & Ming Sun & Er-bao Zhang & Yong-qian Shu
Received: 10 October 2014 / Accepted: 4 December 2014 # International Society of Oncology and BioMarkers (ISOBM) 2014
Abstract Kruppel-like factor 2 (KLF2) expression is diminished in many malignancies. However, its expression and role in nonsmall-cell lung cancer (NSCLC) remain unknown. In this study, we found that KLF2 levels were decreased in NSCLC tissues compared with adjacent normal tissues. Its expression level was significantly correlated with TNM stages, tumor size, and lymph node metastasis. Moreover, patients with low levels of KLF2 expression had a relatively poor prognosis. Furthermore, knockdown of KLF2 expression by siRNA could promote cell proliferation, while ectopic expression of KLF2 inhibited cell proliferation and promoted apoptosis in NSCLC cells partly via regulating CDKN1A/p21 and CDKN2B/p15 Li Yin, Ji-peng Wang, and Tong-peng Xu contributed equally to this work and should be regarded as joint first authors. L. Yin : T.
RESEARCH ARTICLE
Downregulation of Kruppel-like factor 2 is associated with poor prognosis for nonsmall-cell lung cancer Li Yin & Ji-peng Wang & Tong-peng Xu & Wen-ming Chen & Ming-de Huang & Rui Xia & Xin-xin Liu & Rong Kong & Ming Sun & Er-bao Zhang & Yong-qian Shu
Received: 10 October 2014 / Accepted: 4 December 2014 # International Society of Oncology and BioMarkers (ISOBM) 2014
Abstract Kruppel-like factor 2 (KLF2) expression is diminished in many malignancies. However, its expression and role in nonsmall-cell lung cancer (NSCLC) remain unknown. In this study, we found that KLF2 levels were decreased in NSCLC tissues compared with adjacent normal tissues. Its expression level was significantly correlated with TNM stages, tumor size, and lymph node metastasis. Moreover, patients with low levels of KLF2 expression had a relatively poor prognosis. Furthermore, knockdown of KLF2 expression by siRNA could promote cell proliferation, while ectopic expression of KLF2 inhibited cell proliferation and promoted apoptosis in NSCLC cells partly via regulating CDKN1A/p21 and CDKN2B/p15 Li Yin, Ji-peng Wang, and Tong-peng Xu contributed equally to this work and should be regarded as joint first authors. L. Yin : T.
