The Teratology Society, thirtieth annual meeting. June 8-12, 1990, Victoria, BC, Canada. Program, abstracts.

TERATOLOGY 41:497-533 (1990)

THE TERATOLOGY SOCIETY TH IRTIETH ANNUAL MEETING JUNE 8-12, 1990 THE VICTORIA CONFERENCE CENTER VICTORIA, BC, CANADA Program, Abstracts

0 1990 WILEY-LISS. INC

498

TERATOLOGY SOCIETY PROGRAM

TERATOLOGY SOCIETY OFFICERS 1989-90 E.F. ZIMMERMAN President CAROLE A. KIMMEL President-Elect J.M. MANSON Secretary

J . WARKANY 1960-61 J.G. WILSON 1961-62 F.C. FRASER 1962-63 M.M. NELSON 1963-64 D.A. KARNOFSKY 1963-64 L.W. MONIE 1964-65 S.Q. COHLAN 1965-66 M.N. RUNNER 1966-67 R.L. BRENT 1967-68 T.H. SHEPARD 1968-69

A. FANTEL, J . HANSON, KATHLEEN K. SULIK Council Members Past-Presidents of the Society

RONALD P. JENSH Treasurer

R.W. MILLER 1969-70 J . LANGMAN 1970-71 S. PRUZANSKY 1971-72 D.G. TRASLER 1972-73 J.R. MILLER 1973-74 E.M. JOHNSON 1974-75 L.S. HURLEY 1975-76 J.L. SEVER 1976-77 E.V. PERRIN 1977-78 A.B. BEAUDOIN 1978-79

R.M. HOAR 1979-80 C.R. SWINYARD 1980-81 W.J. SCOTT, JR. 1981-82 D.M. KOCHHAR 1982-83 R.E. STAPLES 1983-84 G.P. OAKLEY, JR. 1984-85 L.B. HOLMES 1985-86 A.G. HENDRICKX 1986-87 C.T. GRABOWSKI 1987-88 M.S. CHRISTIAN 1987-88


499

TERATOLOGY SOCIETY COMMITTEES 1989-90 (Date indicates year of expiration of term of office) NOMINATING AND ELECTIONS (1989-90) Phillip E. Mirkes, Chair William Slikker, J r . Robert L. Clark John W. Larsen, Jr. Mildred S. Christian, Past Pres. CONSTITUTION AND BYLAWS Phillip E. Markes-Chair-1990 Judith Parker-1991 Richard A. Byrd-1992 MEMBERSHIP George P. Daston, Chair-1990 John W. Larsen, Jr.-1991 Elaine M. Faustman-1993 HISTORIAN Josef Warkany PUBLICATION Editor-In-C hief Robert L. Brent-1992 (ex-officio) Publication Committee Thomas E. Kwasigrogh, Chair-1991 Patricia M. Rodier-1993 William P. Jollie-1995 Section editors Charles Vorhees-1991 H. Eugene Hoyme-1992 Barbara F. Hales-1992 John C. Carey-1992 F. David Erikson-1992 Frederick R. Bieber-1992 John L.Sever-1992 David A. Beckman-1993 B.K. Nelson-1994 John M. Graham-1995 Mont R. Juchau-1995 Thomas B. Knudsen-1995 Diana M. Juriloff-1995 Others Nigel Brown-1991 Liaison (ex-offcio) Mimeo Yasuda-1993 Liaison (ex-officio) Gregory St. John, John Wiley Publications Ernest F. Zimmerman, President (ex-offcio) FINANCE Ronald Jensh-1992 John M. DeSesso-1992 Carole A. Kimmel-1990

PUBLIC AFFAIRS William J . Scott, Jr.-Chair-l991 Edward J. Lammer-1990 Kathleen K. Sulik-1990 Rochelle W. Tyl-1990 Calvin C. Wilhite-1990 Donald E. Hutchings-1991 Godfrey P. Oakley, Jr.-1991 Mason Barr, Jr.-1991 Thomas A. Marks-1991 Patrick J . Wier-1992 Elaine Z. Francis-1992 Anthony Scialli-1992 Paul W.J. Peters-1992 Carole A. Kimmel, Pres-Elect (ex-officio) Ernest F. Zimmerman, President (ex-officio) LIAISONS WITH OTHER SOCIETIES (1989-90) ACOG-John W. Larsen, J r . AALAC-Gary L. Kimmel ACT-Mildred S. Christian MARTA-Alan M. Hoberman M T A J a n e t Markham SOT-Bernard A. Schwetz American Academy of PediatricsRobert L. Brent American Society of Human GeneticsJohn M. Graham, J r . CORN-Frank Greenberg EDUCATION Richard Hoar-Chair-1991 Ronald Hood-Secretary-1991 Bryan D. Hall-1990 Stanley Kaplan-1990 Robert Kavlock-1992 Robert M. Greene-1992 STUDENT AFFAIRS Robert M. Greene, Chair-1991 Thomas B. Knudsen-1991 Allan S. Goldman-1992 EXECUTIVE SECRETARY Alexandra Ventura AD HOC FUTUREOFTERATOLOGY Ernest Zimmerman Carole Kimmel

500


IFTS-JOINT SYMPOSIUM LIAISON Alan M. Hoberman, Chair Narsingh D. Agnish Mildred S. Christian Elaine Z. Francis Robert E. Staples

Jeanne Manson Ronald Jensh Alan Fantel James Hanson Kathleen Sulik E. Marshall Johnson Robert Greene

1990 PROGRAM COMMITTEE William J . Scott, Jr., Chair George P. Daston Ernest F. Zimmerman

LEGISLATIVE AFFAIRS James W. Hanson Anthony R. Scialli, Chair Gary L. Kimmel Carole A. Kimmel, Ex-officio Ernest F. Zimmerman, Ex-officio

SUSTAINING MEMBERS* WILEY-LISS, INC. AMERICAN PETROLEUM INSTITUTE AMERICAN CYANAMIDiLEDERLE LABS ARGUS RESEARCH LABORATORIES BIOIDYNAMICS, INC. BP AMERICA, INC. BURROUGHS WELLCOME CO. E.I. DuPONT DE NEMOURS & COMPANY ELI LILLY AND COMPANY EXXON BIOMEDICAL SCIENCES HOFFMANN-LA ROCHE, INC. MERCK SHARP & DOHME RES LAB MERRELL DOW RESEARCH INSTITUTE MITRE CORPORATION

MONSANTO CO. PROCTER & GAMBLE CO. R. W. JOHNSON PHARMACEUTICAL RESEARCH INSTITUTE ROHM & HAAS COMPANY SCHERING CORPORATION SMITHKLINE BEECHAM LABORATORIES STERLING-WINTHROP RESEARCH INSTITUTE SYNTEX RESEARCH, INC. UNION CARBIDE CO. UPJOHN CO. WARNER LAMBERT CO. WIL RESEARCH LABORATORIES

*Listing as of February publication deadline. The Teratology Society is pleased to acknowledge contributions from the following companies in support of the 1989 Annual Meeting. Due to early printing deadlines, the organizations below were not included in last year’s program: AMERICAN INDUSTRIAL HEALTH COUNCIL ELI LILLY RESEARCH EXXON BIOMEDICAL SCIENCES GENENTECH, INC. STEPHEN B. HARRIS GROUP HOFFMANN LA ROCHE, INC. INTERNATIONAL RESEARCH & DEVELOPMENT CORPORATION MERCK SHARP & DOHME MILES, INC. RORERCENTRALRESEARCH

SANDOZ RESEARCH G. D. SEARLE, INC. SMITHKLINE & BEECHAM CO. E.R. SQUIBB CO. STERLING RESEARCH CO. WYETH-AYERST, INC. THE STEPHEN B. HARRIS GROUP ICI AMERICAS, INC. G.D. SEARLE & CO. STERLING-WINTHROP RESEARCH INSTITUTE

Contributors to the 1990 Annual Meeting will be listed on a n insert in this year’s program and in the 1991 Annual Meeting program which will appear in the May 1991 issue of TERATOLOGY.


50 1

EXHIBITORS* The Teratology Society is pleased to acknowledge the support of the following exhibitors: WILEY-LISS, INC. ARTHUR D. LITTLE CHEMICAL DESIGNS CRY0 RESOURCES PERGAMON PRESS SAKURA FINETEK SAN DIEGO INSTRUMENTS, INC. ZIVIC MILLER

*Listing as of February publication deadline. A complete listing will appear in the program of the meetings and the June issue of TERATOLOGY.

502


PROGRAM SYNOPSIS TERATOLOGY SOCIETY NEUROBEHAVIORAL TERATOLOGY SOCIETY AM

9:OO-6:00 8:OO-12:OO 8:30-6:00

Thursday, June 7

Registration (Joint) Plaza Coat Check Refresher Course Oak Bay ( B ) Council Meeting I-TS Langford (G)

1:OO-5:OO 3:OO-4:00 4:OO-5:00

1o:oo-12:oo Public Affairs Committee-TS Metchosin (Hi

1:00-3:00 6:30-8:00 8:OO-lO:OO

AM

Friday, June 8

Registration (Joint) Plaza Coat Check Welcome, Warkany Lecture 8:OO-9:15 (Joint) Lecture Theatre Coffee Break (Joint) 9:15-9:40 Plaza Prefunction ExhibitsiDisplays 9:OO-12:OO Plaza Prefunction Symposium I-TS 9:40-11:45 Lecture Theatre Welcome, Symposium I-NBTS 9:40-1150 Esquimalt (C) 1O:OO-11:OO Spouse Coffee Buckingham-Empress 7:00-6:00

11:45-1:30 1:40-3:15

2:OO-5:OO 1:45-3:15 1:45-3: 15 1:45-5:OO 3:15-4:30 3:30-5:00 3:30-5:OO 3:30-500 3:30-500 5 :15-6:30 8:30-1O:OO 8:30-1O:OO

PM

Refresher Course Oak Bay (B) Publications Committee-NBTS Metchosin (H) Developmental Neurotoxicity Protection Committee NBTS Metchosin (Hi Publication Committee-TS Colwood (F) President’s Reception (Joint) Plaza Prefunction Council Meeting-NBTS Sooke (D)

AM

Wilson Lunch-TS Salon A & B Symposium 11-TS Lecture Theatre Exhibits/Displays Plaza Prefunction Platform I-A-TS Sidney (El Platform I-B-TS Colwood (F) Symposium 11-NBTS Esquiinalt (C) Coffee Break (Joint) Plaza Prefunction Platform 11-A-TS Oak Bay ( B ) Platform 11-B-TS Colwood (F) Platform 11-C-TS Lecture Theatre Platform 11-D-TS Sidney (Ei Business Meeting-TS Lecture Theatre Discussion Workshop I-TS Sidney (El Discussion Workshop 11-TS Colwood ( F )

503


PROGRAM SYNOPSIS (CONTINUED) AM

Saturday, June 9 1200-1:30

Registration (Joint) Plaza Coat Check Invited Lecture (Joint) 8:30-9:30 Lecture Theatre 9:30-1O:OO Coffee Break (Joint) Plaza Prefunction 9:OO-12:OO ExhibitsiDisplays Plaza Prefunction 1o:oo-12:oo Symposium 111 (Joint) Lecture Theatre

7:OO-6:00

1:30-3:15 3:15-3:30 3:30-4:30 3:OO-3:15 8:00-9:30 9:45-10:45 9:45-10:45 9:45-10:45

AM

7:00 -1 2:OO 8:lO-10:15 8:00-9:45 9:OO-12:OO 9:45-10:30 1o:oo-12:oo 10:45-12:30 10:45-12:15 10:45-12:15 10:45-12:15

Registration (Joint) Plaza Coat Check SvmDosium IV-TS Lecture Theatre Symposium V NBTS Esquimalt (C) ExhibitdDisplays Plaza Prefunction Coffee Break (Joint) Plaza Prefunction Platform Session NBTS Esquimalt (C) Platform Session 111-A-TS Lecture Theatre Platform Session 111 B-TS Cohood (F) Platform Session I11 C-TS Oak Bay (B) Platform Session 111 D-TS Sidney (E) AM

7:OO-6:00

8:OO-10:05 9:oo-1200 1O:OO-10:30 10:30-12:OO 10:30-12:OO 10:30-12:OO

Sunday, June 10

Past Presidents’ Lunch Metchosin ( H ) Symposium IV-NBTS Esquimalt (C) Coffee Break NBTS Plaza Prefunction Business Meeting-NBTS Esquimalt CC) Coffee Break NBTS Plaza Prefunction Afternoon Free-TS Poster Session I (Joint) Saanich (A) Poster Discussion IA-TS Sidney (E) Poster Discussion IB-TS Colwood (F) Poster Discussion-NBTS Esquimalt (C) PM

Afternoon Free 8:00-9:30 9:45-10:45 9:45-10:45 9:45-10:34

Monday, June 11

Registration Plaza Prefunction Symposium V TS Lecture Theatre ExhibitdDisplays Plaza Prefunction Coffee Break Plaza Prefunction Platform Session IV A-TS Sidney (E) Platform Session IV B-TS Colwood (F) Platform Session IV C-TS Esquimalt (C)

PM

Poster Session 11-TS Suanich (A) Poster Discussion I1 A-TS Sidney ( E ) Poster Discussion I1 B-TS Colwood (F) Poster Discussion I1 C-TS Esquimalt (C)

Prn

Council 11-TS Langford (G) 1:30-3:30 Symposium VI TS Lecture Theatre 2:00-5:00 ExhibitsiDisplays Plaza Prefunction 3~30-3~45 Coffee Break Plaza Prefunction 3:45-5:30 Platform Session V A-TS Lecture Theatre 3:45-5: 15 Platform Session V B-TS Sidney (73) 3:45-5:15 Plaftorm Session V C-TS Colwood (F) 12:oo-2:oo

504


10:30-12:OO Plaftorm Session IV D-TS

Platform Session V D-TS Esquimalt (C) BANQUET-TS Salon A & B

3:45-515

Lecture Theatre 6:OO -10:00

PROGRAM THURSDAY, JUNE 7 REFRESHERCOURSE MOLECULAR BIOLOGY IN THE STUDY OF ABNORMAL DEVELOPMENT SPONSORED BY THE EDUCATION COMMITTEE OF THE TERATOLOGY SOCIETY Richard M. Hoar, Chairman Preregistration is required-contact Dr. Hoar for information: (508) 990-2968 REFRESHER COURSE Oak Bay (B), 8:OO A ~ . - 5 : 0 0P.M. PRINCIPLES. William F. Greenlee, CIIT, Research Triangle Park, North Carolina METHODS AND APPLICATIONS OF MOLECULAR TECHNIQUES TO EARLY DEVELOPMENT. Robert C. Angerer, University of Rochester, Rochester, New York THE EXPRESSION AND FUNCTION OF GROWTH FACTOR LIGANDS AND RECEPTORS DURING EARLY MOUSE EMBRYOGENESIS. Daniel A. Rappolee, University of California School of Medicine, San Francisco, California SEARCHING FOR GENES THAT CONTROL MAMMALIAN DEVELOPMENT. Chi Nguyen-Huu, University of Southern California School of Medicine, Los Angeles, California MOLECULAR BIOLOGICAL ADVENTURES INTO LENS DEVELOPMENT. Michele M. Pisano, National Eye Institute, NIH, Bethesda, Maryland MOLECULAR ANALYSIS OF SUSCEPTIBILITY TO TERATOGENIC AGENTS. David L. Gasser, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

9:OO-6:00

REGISTRATION-PZuza Prefunction

1o:oo-12:oo

PUBLIC AFFAIRS COMMITTEE-Metchosin

1:OO-3:00

PUBLICATIONS COMMITTEE-Colwood

8:30-6:00

COUNCIL MEETING I-Langford

6:30-8:00

PRESIDENTS RECEPTION-Plaza

(H)

(F)

(G) Prefunction

FRIDAY, JUNE 8 Theatre 8:OO-8:30

OPENING REMARKS AND INTRODUCTION TO WARKANY LECTURE. Ernest F. Zimmerman, President of the Teratology Society, Children’s Hospital Research Foundation, Cincinnati, Ohio


505

8:30-9:15

THE JOSEF WARKANY LECTURE: ROLE OF RETINOIC ACID AS A MORPHOGEN AND A TERATOGEN. Devendra M. Kochhar, Department of Anatomy, Jefferson Medical College, Philadelphia, Pennsylvania

9: 15-9:40

BREAK

SYMPOSIUM I Theatre, 9:40 A.M.-1 1:45 A.M. ROLE OF HOMEOBOX GENES AND MORPHOGEN GRADIENTS I N PATTERN FORMATION Ernest F. Zimmerman. Chair 9:40-9:45

OPENING REMARKS. Ernest F. Zimmerman, Children’s Hospital Research Foundation, Cincinnati, Ohio

9:45-10:25

HOX AND KROX GENES IN HINDBRAIN SEGMENTATION. David G. Wilkinson, National Institute for Medical Research, Medical Research Council, London, England

10:25-11:05

INTERACTION AMONG GROWTH FACTORS, HOMEOBOX GENES AND NUCLEAR HORMONE RECEPTORS IN XENOPUS AXIS DETERMINATION. Bruce Blumberg, Department of Biological Chemistry, UCLA School of Medicine, Los Angeles, California

11:05-11:45

EFFECTS OF HOMEOBOX TRANSGENES. Michael Kessel, Department of Molecular Cell Biology, Max-Planck Institute of Biophysical Chemistry, Gottingen, West Germany

11:45-1:30

WILSON LUNCHEON (For graduate students, postdoctoral fellows and all registered attendees) Salon AIB

SYMPOSIUM I1 Theatre, 1:40 P.M.-.3:15 P.M. GRANT WRITING Robert M. Greene, Chair 1:40-1:45

OPENING REMARKS. Robert M. Greene, Jefferson Medical College, Philadelphia, Pennsylvania

1:45-2:15

RECEIPT AND REFERRAL OF GRANT APPLICATIONS SUBMITTED TO THE NIH. Patricia Ann Straat, Chief, Referral Section, Division of Research Grants, NIH, Bethesda, Maryland

2:15-2:45

REVIEW BY THE INITIAL REVIEW GROUP (STUDY SECTION) OF GRANTS SUBMITTED TO THE NIH. Jeanne N. Ketley, Chief, Physiological Sciences Review Section, Division of Research Grants, NIH, Bethesda, Maryland

2:45-3:15

GRANT PROGRAMS SUPPORTED BY THE MARCH OF DIMES. Debbie Bailey-Graaf, Assistant Director for Programs, Grants Administration, March of Dimes, White Plains, New York

506


PLATFORM SESSION I-A Sidney (El, 1:45 P.M.-3:15 P.M. DYSMORPHOLOGY I J o h n M. Graham, J r . , Chair 1:45

1' LOWER EXTREMITY EQUIVALENT OF THE POLAND ANOMALY. Moeschler*, J.D., M.J. Edwards", and J.M. Graham, Jr., Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, Dept. of Maternal and Child Health, Hanover, New Hampshire and UCLA School of Medicine (MJE, JMG) Cedars-Sinai Medical Center, Dept. of Pediatrics, Los Angeles, California

2:oo

2 ARTHROGRYPOSIS, WHISTLING FACIES, CARDIOMYOPATHY, PTERYGIA AND DERMATOGLYPHIC ANOMALIES: COMPONENTS OF A PATHOGENESIS PUZZLE. Wertelecki, W. and D.W. Superneau, Department of Medical Genetics, University of South Alabama, Mobile, Alabama

2:15

3 CHARGE ASSOCIATION AND LIMB MALFORMATIONS. Superneau, D.W. and W. Wertelecki, Department of Medical Genetics, University of South Alabama, Mobile, Alabama

2:30

4

2:45

5 THE PATTERN AND FORM OF HUMAN SOMATIC STRUCTURAL ECTOPY. Tick, D.B.l, F. Greenberg', and J.M. Graham, Jr.', Medical Genetics-Birth Defects Center, Ahmanson Pediatric Center, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, California' and Institute for Molecular Genetics, Baylor College of Medicine, Houston, Texas

3:OO

6 OCULAR COLOBOMAS. Miller, M.T., Department of Ophthalmology, University of Illinois a t Chicago Eye and Ear Infirmary, Chicago, Illinois

3:15

BREAK

PATHOGENETIC EMBRYOLOGIC INTERRELATIONSHIP OF HEMIFACIAL MICROSOMIA AND THE VATERMRENOMELIA PHENOTYPES. Duncan, P.A. and L.R. Shapiro, Departments of Pediatrics and Pathology, New York Medical College, Valhalla, New York

PLATFORM SESSION I-B Colwood (F), 1:45 P.M.-3:15 P.M. RISK ASSESSMENT Joseph F. Holson, Chair 1:45

7 MATHEMATICAL MODELLING AND DETERMINATION OF THE VIRTUALLY SAFE DOSE FROM TERATOGENICITY STUDIES AND THEIR IMPACT ON STUDY DESIGN. Wickramaratne, G.A. de S. and S.K. Cook*, Central Toxicology Laboratory, ICI Plc, Alderley Park, Nr Macclesfield, Cheshire, UK

2:oo

8

2:15

9 A COMPREHENSIVE BIOLOGICAL MODEL FOR CLEFT PALATE INTENDED AS A BASIS FOR QUANTITATIVE RISK ASSESSMENT. Freni,

ANALYSIS OF THE ADEQUACY OF SAFETY FACTORS. Sheehan, D.M. and D.W. Gaylor, Divisions of Reproductive and Developmental Toxicology and Biometry, National Center for Toxicological Research, FDA, Jefferson, Arkansas

'Abstracts are numbered in the order that the presentation occurs in the program. An author's index is provided *Indicates non-members of the Teratology Society throughout.


507

S.C.", Biometry Staff, National Center for Toxicological Research, Jefferson, Arkansas ,230

10 BIOLOGICALLY-BASED DOSE-RESPONSE MODELS (BBDRM) FOR DEVELOPMENTAL DEFECTS. Gaylor, D.W.", S.C. Freni*, J.J. Chen*, and R.L. Kodell", Biometry Staff, National Center for Toxicological Research, Jefferson, Arkansas

2:45

11 DESIGN CONSIDERATIONS FOR A DYNAMIC PHYSIOLOGICAL FLOW MODEL FOR PREGNANCY. Young, J.F., R.H. Luecke", W.D. Wosilait", and B.A. Pearce*, Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas and Departments of Chemical Engineering and Pharmacology, University of Missouri, Columbia, Missouri

3:OO

12 ASSESSMENT OF A TERATOGENIC POTENCY USING A MODIFIED DOSING SCHEDULE. Neubert, D., S. Klug*, I. Chahoud, and R. Stahlmann, Institutu fur Toxikologie und Embryopharmakologie, Freie Universitat Berlin, FRG

3:15

BREAK

PLATFORM SESSION 11-A Oak Bay (B), 330 P.M.-5:00 P.M. EPIDEMIOLOGY I Allen A. Mitchell, Chair 3:30

13 THE TERATOGENIC EFFECTS OF ANTICONVULSANT MONOTHERAPY: PHENOBARBITAL (Pb), CARBAMAZEPINE (CBZ) AND PHENYTOIN (PHT). Holmes, L.B., E.A. Harvey*, A.M. Hayes", K.S. Brown", D.A. Schoenfeld" and S. Koshbin*, Massachusetts General Hospital, Boston, Massachusetts

3:45

14 SPINA BIFIDAE IN MATERNAL CARBAMAZEPINE EXPOSURE COHORT DATA. Rosa", F.W., Food and Drug Administration, Rockville, Maryland

4:OO

15 DESCRIPTIVE EPIDEMIOLOGY OF ORAL CLEFTS IN CALIFORNIA. Croen, L.A.", G.M. Shaw, and C.J. Curry, March of Dimes, California Birth Defects Monitoring Program, 5900 Hollis Street, Suite A, Emeryville, California, Medical Genetics, Valley Children's Hospital, Fresno, California

4: 15

16 EBSTEIN'S ANOMALY AND MATERNAL LITHIUM EXPOSURE DURING PREGNANCY. Edmonds", L.D. and G.P. Oakley, Birth Defects and Genetic Diseases Branch, Center for Disease Control, Atlanta, Georgia

4:30

17 LEAD AND SOLVENT EXPOSURE DURING PREGNANCY: POSSIBLE RISK OF CARDIOVASCULAR MALFORMATIONS (CVM). Correa", A,, C. Loffredo", C. Ferencz, P.D. Wilson*, and the Baltimore-Washington Infant Study (BWIS) Group, Johns Hopkins Medical Institutions, Baltimore, Maryland

4:45

18 THE DESCRIPTIVE EPIDEMIOLOGY OF VASCULAR DISRUPTIONS, ATLANTA AND IOWA. Cordero, J.F. and J.W. Hanson, Division of Birth Defects and Developmental Disabilities, Centers for Disease Control, Atlanta, Georgia, and the Division of Medical Genetics, Department of Pediatrics, University of Iowa School of Medicine, Iowa City, Iowa

508


PLATFORM SESSION 11-B Colwood (F), 3:30 P.M.-5:00 P.M. PHARMACOKINETICS J o h n F. Young, Chair 3:30

19 A TOXICOKINETIC MODEL FOR PREGNANT RODENTS. O'Flaherty, E.', W. Scott', C. Schreiner ', and R. Beliles3, Environmental Health, University of Cincinnati', Children's Hospital Research Foundation', Cincinnati, Ohio and U S . EPA3, Washington, D.C.

3:45

20 RADIATION AND CHEMICAL DOSIMETRY OF THE EMBRYO AND FETUS. Sikov, M.R., H.K. Memarich*, and B.J. Kelman, Life Sciences Center, Pacific Northwest Laboratory, Richland, Washington

4:OO

21 COMPARISON OF DRUG DISPOSITION IN THE HUMAN DURING TREATMENT WITH 13-CIS-RETINOIC ACID (0.7 MGIKGIDAY) AND IN THE CYNOMOLGUS MONKEY (10 MGIKGIDAY). Creech Kraft, J.', J.R. Bailey'", L.G. Roberts', B. Fischer"', W. Wittfoht"', H. Nau', and W. Slikker, Jr.', 'Inst. of Toxicology and Embryopharmacology, F.U., Berlin; 'NCTR, Jefferson, Arkansas

4:15

22 EMBRYO DOSIMETRY AND INCIDENCE OF MALFORMATIONS IN CD1 MICE FOLLOWING SUBCUTANEOUS INFUSION OF X-METHOXYETHANOL (2-ME). Clarke*, D.O., J.M. Duignan", and F. Welsch, CIIT, Research Triangle Park, North Carolina

4:30

23 KINETICS OF LEAD DURING PREGNANCY, LACTATION AND INFANT DEVELOPMENT O F RHESUS MONKEYS. Sonawane, B.R., K. Hoang*, J . Blancato", and N.K. Laughlin, U S . Environmental Protection Agency, Washington, D.C. and Harlow Primate Laboratory, University of Wisconsin, Madison, Wisconsin

4145

24 INFLUENCE OF MILK FORMULA ON KINETICS O F LEAD (Pb) BODY BURDEN DURING DEVELOPMENT OF RHESUS MONKEYS. Laughlin, N.K., B.R. Sonawane, K. Hoang", and J.R. Blancato:K.Harlow Primate Laboratory, University of Wisconsin, Madison, Wisconsin, and the U.S. Environmental Protection Agency, Washington, D.C.

PLATFORM SESSION 11-C

Theatre, 3:30 P.M.-5:00 P.M. GENETICS Fred G. Biddle, Chair 3:30

25 iviiv MICE AND LATERAL ASYMMETRY: THE DEVELOPMENT OF VISCERAL SITUS IN iviiv PLUS + I + CHIMERIC EMBRYOS, AND THE INVERSION OF A LEFT-RIGHT TISSUE OXYGEN GRADIENT IN SITUS INVERSUS. Brown, N.A., A. McCarthy*, and L. Wolpert*, MRC Expl. Embryology and Teratology Unit, St. George's Hosp. Med. Sch., and Dept. Anat. and Dev. Biol. Univ. Coll. and Middlesex Hosp. Med. Sch., London, U.K.

3:45

26 STUDIES OF THE EFFECTS OF INTERACTION OF RETINOIC ACID AND GENETIC LIABILITY ON NEURAL TUBE CLOSURE IN MICE. Juriloff, D.M., C. Tom*, and M.J. Harris, Department of Medical Genetics, University of British Columbia, Vancouver, Canada


509

4:OO

27 INTERACTION OF RETINOIC ACID (RA) WITH THE MOUSE MUTANT LEGLESS (lgl) ON LIMB AND TAIL DEVELOPMENT. Wegner, Chr., B. Lofberg, W. Scott, D. Supp, and S.Potter, Children's Hospital Research Foundation, Cincinnati, Ohio

4:15

28 IN PURSUIT OF THE FIRST ARCH MUTATION. Juriloff, D.M. and M.J. Harris, Department of Medical Genetics, University of British Columbia, Vancouver, Canada

4:30

29 ANALYSIS OF THE SYNDROME OF CONGENITAL MALFORMATIONS INDUCED IN GENETICALLY DEFINED MICE BY ACUTE RIBOFLAVIN DEFICIENCY. Kalter, H., Children's Hospital Research Foundation and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio

4:45

30 PRENATAL PREDICTION OF RISK FOR THE FETAL HYDANTOIN SYNDROME. Finnell, R.H., M. van Waes*, D. Delimont* and B.A. Buehler, Department of Genetics and Cell Biology, Washington State University, Pullman, Washington (RHF and MVW) and (DD and BAB) Hattie B. Munroe Center for Human Genetics, University of Nebraska, Omaha, Nebraska

PLATFORM SESSION 11-D Sidney (El, 3:30 P.M.-5:00 P.M. PLACENTAL FUNCTION Richard K. Miller, Chair 3:30

31 AMINO ACID EXCHANGE AND UTILIZATION IN PROTEIN SYNTHESIS IN EARLY RAT CONCEPTI. Beckman, D.A., T.R. Koszalka, J.B. Lloyd and R.L. Brent, Department of Pediatrics, Thomas Jefferson University, Philadelphia, Pennsylvania, Alfred I du Pont Institute, Wilmington, Delaware

3:45

32 FINE STRUCTURAL OBSERVATIONS ON EFFECTS OF DIETARY ETHANOL ON DEVELOPMENT OF THE RAT YOLK-SAC PLACENTA. Jollie, W.P., Department of Anatomy, Medical College of VirginiaiVirginia Commonwealth University, Richmond, Virginia

4:OO

33 EFFECT OF TRYPAN BLUE ON YOLK SAC GAMMA-GLUTAMYLTRANSFERASE (GGT) ACTIVITY DURING GESTATION IN RATS. Andrews, J.E.* and J.M. Rogers, Developmental Toxicology Division, HERL, USEPA, Research Triangle Park, North Carolina

4:15

34 THE TERATOGENIC EFFECTS OF E-64 (A THIOL PROTEASE INHIBITOR) ON RAT EMBRYOGENESIS, IN COMPARISON WITH THE RESULTS OF LEUPEPTIN AND ANTI-TISSUE SERUM. Miyata, K., S-F. Chen'::, M. Ninomiya*, S. Oku*, and S. Ono*, Department of Pediatrics, Faculty of Medicine, Kagoshima University, Kagoshima, Japan

4:30

35 POLYNUCLEAR AROMATIC HYDROCARBON (PAH) TOXICITY SUSCEPTIBILITY OF THE HUMAN TERM PLACENTA. Sanyal", M.K., Y.L. Li* and W.J. McMurray*, Department of Obstetrics and Gynecology and Comprehensive Cancer Center, Yale University Medical School, New Haven, Connecticut

4:45

36 EXTRACELLULAR MATRIX AND FIBRIN ALTER THE PROLIFERATION AND CYTOLOGY BUT NOT THE HORMONE SECRETION OF CULTURED HUMAN CELLULAR TROPHOBLAST. Farmer, D.R., E. Curran" and D.M. Nelson*, Dept., ObiGyn, Washington Univ. School of Med., St. Louis, Missouri

510


BUSINESS MEETING Theatre, 5:15 P.M.-6:30 P.M. DISCUSSION SESSION I Sidney (El, 8:30 P.M.-10:00 P.M.

PHOSPHOINOSITIDE/ARACHIDONICACID METABOLISM AND TERATOGENESIS Allen S. Goldman. Discussion Leader DISCUSSION SESSION 11 Colwood (F),8:30P.M.-1O:OO P.M RISK ASSESSMENT George P. Daston, Discussion Leader

SATURDAY, J U N E 9 Theatre, 8:30 A.M.-9:30 A . M . 8:30-9:30

INVITED LECTURE. COCAINE: TERATOGEN EPIDEMIC. Thomas Shepard, University of Washington, Seattle, Washington Discussant-Donald Hutchings, New York State Psychiatric Institute, New York, New York Co-sponsored by the Public Affairs Committee and the Neurobehavioral Teratology Society

9:30-1O:OO

BREAK

SYMPOSIUM I11 Theatre, 1O:OO A.M.-12:OO P.M. SOCIAL AND ECONOMIC COSTS OF ALCOHOL EXPOSURE DURING PREGNANCY Co-sponsored by the Public Affairs Committee and the Neurobehavioral Teratology Society Thomas A. Marks and Edward P. Riley, Co-Chairs 10:00-10:05

INTRODUCTION. Thomas A. Marks, The Upjohn Company, Kalamazoo, Michigan

10:05-10:30

FETAL ALCOHOL SYNDROME AMONG NATIVE AMERICANS. Jon M. Aase, University of New Mexico School of Medicine, Albuquerque, New Mexico

10:30-10:55

NEW UNDERSTANDINGS OF THE FACE AND BRAIN IN FETAL ALCOHOL SYNDROME. Sterling Clarren, Children’s Hospital and Medical Center, Seattle, Washington

10:55-11:20

LONG-TERM NEUROBEHAVIORAL EFFECTS OF PRENATAL ALCOHOL EXPOSURE. Ann P. Streissguth, University of Washington, Seattle, Washington


511

11:20-11:45

EFFECTS OF PRENATAL ALCOHOL EXPOSURE ON GROWTH AND MORPHOLOGY. Nancy L. Day, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

11:45-12:OO

DISCUSSION

12:OO-1:30

PAST PRESIDENT'S LUNCHEON, Metchosin (Hi

POSTER SESSION I Saanich (A), 8:OO P.M.-9:30) P.M. (Posters should be set up after 1:00 P.M. Saturday a n d removed by midnight; Numbers P37-P58 should be attended from 8:OO P.M.-8:45 P.M. a n d Numbers P59-P78 attended from 8:45 P.M.-9:30 P.M.) Refreshments Available P37 REPRODUCTIVE AND TERATOGENIC EFFECTS OF A MAJOR EARTHQUAKE IN SPRAGUE-DAWLEY RATS. Fujinaga, M., J.M. Baden, and R.I. Mazze, Department of Anesthesia, Stanford University School of Medicine, Stanford, California and Palo Alto V.A. Medical Center, Palo Alto, California P38 DEVELOPMENTAL TOXICITY STUDY OF N-METHYLFORMAMIDE (MMF) INHALATION IN THE RAT. Rickard*, L.B. and C.D. Driscoll, Haskell Laboratory, E.I. du Pont de Nemours and Co., Inc., Newark, Delaware P39 TERATOLOGY STUDY WITH (2-NAPHTHOXY) ACETIC ACID IN RATS. Henwood, S.M. and T.G. Osimitz*, Hazleton Laboratories America, Inc., Madison, Wisconsin, and SC Johnson and Son, Inc., Racine, Wisconsin P40 DEVELOPMENTAL STAGES OF THE CD@RAT SKELETON AFTER MATERNAL EXPOSURE TO ETHYLENE GLYCOL (EG). Marr, M.C., C.J. Price, C.B. Myers*, R.E. Morrissey and B.A. Schwetz, Research Triangle Institute and NIEHSINTP, Research Triangle Park, North Carolina P41 DEVELOPMENTAL TOXICITY OF DINITROANILINES. I. TRIFLURALIN. Byrd, R.A. and J.K. Markham, Toxicology Division, Lilly Research Laboratories, Eli Lilly and Co., Greenfield, Indiana P42 DEVELOPMENTAL TOXICITY OF DINITROANILINES. 11. ETHALFLURALIN. Byrd, R.A., E.R. Adams*, K. Robinson, and J.K. Markham, Toxicology Division, Lilly Research Laboratories, Eli Lilly and Co. Greenfield, Indiana, and Bio-Research Laboratories Ltd., Senneville, Quebec P43 DEVELOPMENTAL TOXICITY OF DINITROANILINES. 111. ORYZALIN. Byrd, R.A., W.H. Jordan", and J.K. Markham, Toxicology Division, Lilly Research Laboratories, Eli Lilly and Co., Greenfield, Indiana P44 DEVELOPMENTAL TOXICITY EVALUATION OF CHLORDENE IN SPRAGUE-DAWLEY RATS. Nemec, M.D., E.J. Tasker, A.M. Khasawinah', WIL Research Laboratories, Inc., Ashland, Ohio and 'Velsicol Chemical Corporation P45 A THREE-GENERATION STUDY IN RATS WITH PRAVADOLINE ADMINISTERED ORALLY. Dennis, M.M., J.C. Bradford, G.L. Brown and W.F. Blazak, Department of Toxicology, Sterling Research Group, Rensselear, New York P46 INHIBITION OF FETAL OSSIFICATION IN RATS BY FEZOLAMINE. Brown, G.L., M.M. Dennis, K.A. Kolberg" and W.F. Blazak, Department of Toxicology, Sterling Research Group, Rensselaer, New York

512


P47 EVALUATION OF THE DERMAL ABSORPTION AND TERATOGENIC POTENTIAL OF METHYL SALICYLATE IN A PETROLEUM BASED GREASE. Infurna, R., B. Beyer, L. Twitty*, G. Koehler*, and W. Daughtrey*, Exxon Biomedical Sciences, Inc., E. Millstone, New Jersey P48 NEGATIVE DEVELOPMENTAL TOXICITY TEST OF TABUN (GA) IN THE NEW ZEALAND WHITE RABBIT. Denny, K.H., R.M. Parker, B.L. Divine, T.J., Bucci, and **J.C. Dacre, Pathology Associates, Inc., National Center for Toxicological Research, Jefferson, Arkansas, and **US. Army Biomedical R and D Laboratory, Fort Detrick, Maryland P49 EFFECTS OF SMOKELESS TOBACCO AND ALCOHOL ON CRANIOFACIAL MEASUREMENTS. Paulson, R., J. Shanfeld*, M. Fernandez”, J. Dean*, and J. Paulson*, Department of Oral Biology, OSU and Ohio Department of Health, Columbus, Ohio P50 DEVELOPMENTAL TOXICITY OF TRIETHYLENE GLYCOL DIMETHYL ETHER (TGDM) IN NEW ZEALAND WHITE RABBITS. George, J.D., C.J. Price, M.C. Marr, R.E. Morrissey and B.A. Schwetz, Research Triangle Institute and National Toxicology ProgramiNIEHS, Research Triangle Park, North Carolina P51 DEVELOPMENTAL TOXICITY OF BUTYL BENZYL PHTHALATE (BBP) IN MICE AND RATS. Price, C.J., E.A. Field*, M.C. Marr, C.B. Myers“, R.E. Morrissey, and B.A. Schwetz, Research Triangle Institute and National Toxicology ProgramiNIEHS, Research Triangle Park, North Carolina P52 REPRODUCTIVE TOXICITY STUDY OF 1,2,4,5-TETRACHLOROBENZENE (TCB) IN THE DIET OF CD (SPRAGUE-DAWLEY) RATS. Neeper-Bradley*, T.L., R.W. Tyl, L.C. Fisher*, D.L. Fait*’, M.A. Vrbanic*, P.E. Losco”, and C.R. Stack”, Bushy Run Research Center, Export, Pennsylvania and Chemical Manufacturers Associationa, Washington, D.C. P53 DEVELOPMENTAL TOXICITY EVALUATION OF 1,2,4,5-TETRACHLOROBENZENE (TCB) ADMINISTERED BY GAVAGE TO FISCHER 344 (F-344) RATS AND NEW ZEALAND WHITE (NZW) RABBITS. Fisher*, L.C., R.W. Tyl, B.L. Butler”, M.A. Vrbanic*, J.P. Van Miller*, and C.R. Stack”, Bushy Run Research Center, Export, Pennsylvania and Chemical Manufacturers Associationa, Washington, D.C. P54 EVALUATION OF THE DEVELOPMENTAL TOXICITY OF PROPYLENE DICHLORIDE IN RATS AND RABBITS. Hanley, T.R., Jr., H.D. Kirk*, N.M. Berdasco*, and K.A. Johnson”, Toxicology Research Laboratory, The Dow Chemical Company, Midland, Michigan P55 GENE EXPRESSION IN IN VITRO LIMB CULTURE. Zakeri, Z.F.l, F. Farooqui*l and R. Behringer*’, ‘Dept. of Physiology and Biophysics, UMDNJ-Robert Wood Johnson Medical School, Piscataway, New Jersey and 2Dept. of Anatomy, U. of Penn. School of Veterinary Medicine, Philadelphia, Pennsylvania P56 IMMUNODETECTION OF THE TRANSFORMING GROWTH FACTORS p1 AND p2 IN THE DEVELOPING MURINE PALATE. D’Angelo, M., A.L. Gehris, and R.M. Greene, Department of Anatomy, Jefferson Medical College, Philadelphia, Pennsylvania P57 STRESS PROTEINS, TERATOGENESIS AND RETINOIC ACID: A CORRELATIVE STUDY IN MICE. LaBorde, J.B., J.F. Anson*, J.L. Pipkin*, W.G. Hinson*, D.K. Hansen, D.M. Sheehan, and J.F. Young, Divisions of Reproductive and Developmental Toxicology and Genetic Toxicology, National Center for Toxicological Research, Jefferson, Arkansas P58 Z-DNA IMMUNOREACTIVITY IN ABNORMALLY DEVELOPED MOUSE NONCATARACTOUS CRYSTALLINE LENS. Gagna, C.E. and O.G. Mitchell*, Department of Anatomy, New York University Dental Center, New York, New York P59 REGULATION OF CONCEPTAL P450 ISOFORMS WITH CYCLIC NUCLEOTIDES AND PHOSPHODIESTERASE INHIBITORS. Lee*, Q.P. and M.R. Juchau, Department of Pharmacology, School of Medicine, University of Washington, Seattle Washington P60 DETECTION OF TERATOGENS BY UTILIZATION OF P-GALACTOSIDASE REPORTER GENE TECHNOLOGY. Bournias-Vardiabasis, N., J . Ananthan-Nair*, and R. Voellmy*, Department


513

of Biology, California State University, San Bernardino, California; *Departments of Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, Florida P61 DISPOSITION AND METABOLISM OF CHRONICALLY ADMINISTERED RETINOL IN THE MONKEY. Slikker, W., Jr., C. E c k h o P , W. Wittfoht*, M. Collins, W.J. Scott, Jr., J.R. Bailey", and H. Nau, Division of Reproductive and Developmental Toxicology, NCTRIFDA, Jefferson, Arkansas, Children's Hospital Research Foundation, Cincinnati, Ohio, Institute of Toxicology and Embryopharmacology, Free University, Berlin P62 OXIDATION AND GLUCURONIDATION PATHWAYS OF RETINOL METABOLISM AS A FUNCTION OF DOSE AND PHARMACEUTICAL PREPARATION OF VITAMIN A IN THE MONKEY. E c k h o P l , C., J.R. Bailey*', W. Slikker, Jr2, and H. Nau', 'Institut fur Toxikologie und Embryopharmakologie, Freie Universitat Berlin, Germany, and *Division of Reproductive and Developmental Toxicology, NCTR/FDA, Jefferson, Arkansas P63 14C-ETHANOL IS NOT REGIONALLY SEQUESTERED IN DEVELOPING MOUSE EMBRYOS. Namovic, M.T.', McCandless, D.W.', C.M. Schreiner', and W.J. Scott', 'Dept. of Cell Biology and Anatomy,Chicago Medical School, North Chicago, Illinois and 'Children's Hospital Research Foundation, Cincinnati, Ohio P64 A PHARMACOKINETIC ANALYSIS OF PHENOL IN THE PREGNANT RAT: DEPOSITION IN THE EMBRYO AND MATERNAL TISSUES. Gray, J.A. and R.J. Kavlock, Developmental Toxicology Division, U S . EPA, Research Triangle Park, North Carolina P65 DOSIMETRY OF p-CYANOPHENOL IN AN IN VIVO DEVELOPMENTAL TOXICITY BIOASSAY. Copeland*, M.F., R.J. Kavlock, J.A. Gray, E.H. Rogers*, and B.F. Rehnberg", USEPA, DTD, PTB, Research Triangle Park, North Carolina P66 CONSIDERATION OF PHARMACOKINETICS AND TEMPORAL SENSITIVITY FOR HY DROXYUREA IN PREGNANT RATS AND RHESUS MONKEYS. Beliles, R.P., N.G. Makris, and W.J. Scott, U.S. Environmental Protection Agency, Washington, D.C.; NGM Consulting, Falls Church, Virginia; and Children's Hospital Research Foundation, Cincinnati, Ohio P67 CHANGES IN THE PATTERN OF CARDIAC ANOMALIES DURING LATE FETAL DEVELOPMENT OF TRIMETHADIONE EXPOSED RATS. Veuthey*, S., and T. Pexieder, Institut d'Histologie et d'Embryologie, Universite de Lausanne, Lausanne, Switzerland P68 THE EFFECTS OF DICHLOROACETIC ACID (DCA) ON CARDIOGENESIS IN THE LONGEVANS RAT FETUS. Epstein+, D.L., G. Nolen+, J.L. Randall+, S.A. Christ*, E.J. Read*', J.A. Stober*, and M.K. Smith, *PAI, Cincinnati, Ohio, HERL, USEPA, and 'Computer Sciences Corporation, Cincinnati, Ohio P69 ALTERED CARDIAC PARAMETERS IN CHICK EMBRYOS TREATED WITH A TERATOGENIC DOSE OF DOPAMINE. Kuhlmann, R.S., H.E. Shields* and G.L. Kolesari, Department of Anatomy and Cellular Biology, Medical College of Wisconsin, Milwaukee, Wisconsin P70 CAPACITY OF THE CHICK EMBRYO FOR XENOBIOTICA METABOLISM AT VARIOUS STAGES OF DEVELOPMENT. Heinrich-Hirsch*, B., D. Hofmann*, and D. Neubert, Institut fur Toxikologie und Embryopharmakologie, Freie Universitat Berlin, FRG P71 COMPARATIVE CARDIOTERATOGENIC AND EMBRYOLETHAL EFFECTS OF SODIUM VALPROATE AND PHENYTOIN IN WHITE LEGHORN CHICK EMBRYOS. Bruyere, H.J., Jr., School of Pharmacy, University of Wyoming, Laramie, Wyoming P72 CHARACTERIZATION OF THE EXTRACELLULAR MATRIX IN DEVELOPMENTAL STAGES 8-10 IN THE MACAQUE. Peterson, P.E., J.R. Rowland*, D.B. Wilson and A.G. Hendrickx, California Primate Research Center, University of California, Davis, California; Division of Anatomy, Dept. of Surgery, School of Medicine, University of California, San Diego, La Jolla, California P73 SPATIO-TEMPORAL RELATIONSHIPS AT THE TIME OF INITIAL DEVELOPMENT OF THE TONGUE, PALATE AND MANDIBLE. Young*, A.V., E.J.E. Feeley*, G. Benkhaial*, and R.M. Shah, Department of Oral Biology, University of British Columbia, Vancouver, Canada

514


P74 PATHOGENESIS OF BROMODEOXYURIDINE-INDUCED CLEFT PALATE IN HAMSTER. Feeley”, E.J.E., and R.M. Shah, Department of Oral Biology, University of British Columbia, Vancouver, B.C., Canada P75 COLLAGEN SYNTHESIS DURING 5-FLUOROURACIL-INDUCED CLEFT PALATE. Benkhaial”, G., E.J.E. Feeley”, and R.M. Shah, Department of Oral Biology, University of British Columbia, Vancouver, B.C., Canada P76 THE RELATIONSHIP OF TONGUE AND MANDIBLE GROWTH TO ETRETINATEINDUCED CLEFT PALATE. Chun, Y.H. and C.H. Kim,” Department of Anatomy, Korea University Medical College, Seoul, Korea P77 THE DEVELOPMENTAL TOXICITY HAZARD-POTENTIAL OF DIMETHYLETHOXYSILANE AS DETERMINED BY THE IN VITRO HYDRA ASSAY. Johnson, E.M. and LM. Newman, Daniel Baugh Institute, Jefferson Medical College, Philadelphia, Pennsylvania P78 DEVELOPMENTAL TOXICITY OF RETINOYLAMINO ACIDS: ENDGROUP MODIFICATION ALTERS ACTIVITY. Kochhar, D.M., J.D. Penner”, and Y. Fulmer Shealy,* Department of Anatomy, Jefferson Medical College, Philadelphia, Pennsylvania, and Southern Research Institute, Birmingham, Alabama

POSTER DISCUSSION SESSION I-A Sidney (E), 9:45 P.M.-10:45 P . M . MOLECULAR BIOLOGY Philip E. Mirkes, Chair P55 GENE EXPRESSION IN IN VITRO LIMB CULTURE. Zakeri et a1 P56 IMMUNODETECTION OF THE TRANSFORMING GROWTH FACTORS pl AND p2 IN THE DEVELOPING MURINE PALATE. D’Angelo et al. P57 STRESS PROTEINS, TERATOGENESIS AND RETINOIC ACID: A CORRELATIVE STUDY IN MICE. LaBorde et al. P58 Z-DNA IMMUNOREACTIVITY IN ABNORMALLY DEVELOPED MOUSE NONCATARACTOUS CRYSTALLINE LENS. Gagna et al. P59 REGULATION OF CONCEPTAL P450 ISOFORMS WITH CYCLIC NUCLEOTIDES AND PHOSPHODIESTERASE INHIBITORS. Lee et al. P60 DETECTION OF TERATOGENS BY UTILIZATION OF p-GALACTOSIDASE REPORTER GENE TECHNOLOGY. Bournias-Vardiabasis et al.

POSTER DISCUSSION SESSION I-B Colwood (F), 9:45 P.M.-10:45 P.M. PHARMACOKINETICS Robert J. Kavlock, Chair P61 DISPOSITION AND METABOLISM OF CHRONICALLY ADMINISTRED RETINOL IN THE MONKEY. Slikker et al. P62 OXIDATION AND GLUCURONIDATION PATHWAYS OF RETINOL METABOLISM AS A FUNCTION OF DOSE AND PHARMACEUTICAL PREPARATION OF VITAMIN A IN THE MONKEY. Eckhoff et al. P63 14C-ETHANOL IS NOT REGIONALLY SEQUESTERED IN DEVELOPING MOUSE EMBRYOS. Namovic et al.


515

P64 A PHARMACOKINETIC ANALYSIS OF PHENOL IN THE PREGNANT RAT: DEPOSITION IN THE EMBRYO AND MATERNAL TISSUES. Gray et al. P65 DOSIMETRY OF p-CYANOPHENOL IN AN IN VIVO DEVELOPMENTAL TOXICITY BIOASSAY. Copeland et al. P66 CONSIDERATION OF PHARMACOKINETICS AND TEMPORAL SENSITIVITY FOR HYDROXYUREA IN PREGNANT RATS AND RHESUS MONKEYS. Beliles et al.

SUNDAY, JUNE 10 SYMPOSIUM IV Theatre, 8:lO A.M.-10:15 A . M . PROGRAMMED CELL DEATH William J. Scott, J r . , Chair 8:10-8:15

OPENING REMARKS. William J. Scott, Children's Hospital Research Foundation, Cincinnati, Ohio

8:15-8:55

PROGRAMMED CELL DEATH IN THE NEUROPHIL AND RECOGNITION BY MACROPHAGES. Christopher Haslett, Department of Medicine, Hammersmith Hospital, London, England

8:55-9:35

PHYSIOLOGICAL AND PROGRAMMED CELL DEATH: NEW PROTEINS SYNTHESIZED JUST BEFORE CELLS DIE. Richard Lockshin, Department of Biological Sciences, St. John's University, Jamaica, New York

9:35-10:15

PHYSIOLOGICAL CELL DEATH: A "BLUEPRINT' OF MALFORMATION PATTERNS. Kathleen K. Sulik, Department of Cell Biology and Anatomy, University of North Carolina, Chapel Hill, North Carolina

10:15-10:45

BREAK PLATFORM SESSION 111-A Theatre. 10:45 A.M.-12:30 P.M. CLINICAL NEURAL TUBE DEFECTS Ronald J. Lemire, Chair

10:45

79 NEURAL TUBE CLOSURE: SCANNING ELECTRON MICROSCOPIC STUDIES OF NORMAL RAT AND DYSRAPHIC HUMAN EMBRYOS. Shepard, T.H., K.A. Holbrook", and K. Shiota, Departments of Pediatrics, Biological Structure, University of Washington, Seattle, Washington, and Department of Anatomy, Kyoto University School of Medicine, Kyoto, Japan

11:oo

80 FERTILITY DRUGS AND INFERTILITY AS RISK FACTORS FOR NEURAL TUBE DEFECTS. The NICHD Neural Tube Defects Study, Mills", J.L. presenter (Introduced by D. Dayton), National Institutes of Health, Bethesda, Maryland

11:15

81 EVIDENCE FOR A FACTOR COMMON TO TWINNING AND NEURAL TUBE DEFECTS (NTDs), AND SOME IMPLICATIONS. Fraser, F.C., B. Garabadian" and E. O'Leary", McGill Centre for Human Genetics, Montreal and Division of Community Medicine, Memorial University, St. John's, Newfoundland, Canada

516


11:30

82 THE CHANGING EPIDEMIOLOGY OF NEURAL TUBE DEFECTS, ATLANTA, 1969-1988. Khoury", M.J., J.F. Cordero, and W.D. Patterson, Birth Defects and Genetic Diseases Branch, Centers for Disease Control, Atlanta, Georgia

11:45

83 REEVALUATION OF CENTRAL NERVOUS SYSTEM ANOMALIES ASSOCIATED WITH THE EARLY AMNION RUPTURE SEQUENCE. Ohriner", W.D., K.N. Rosenbaum, and H.M. Saal*, Department of Clinical Genetics, Children's National Medical Center, Washington, D.C.

12:oo

84 HIGH RELATIVE FREQUENCY OF ENCEPHALOCELES IN A SOUTH CAROLINA POPULATION. Suchy*, S.F., R.E. Stevenson*, and M.C. Phelan, Greenwood Genetic Center, Greenwood, South Carolina

12:15

85 COMPUTER ARCHIVE AND MODELING OF A SECTIONED HUMAN EMBRYO. Hilbelink, D.R. and R. Gasser, Department of Anatomy, University of South Florida, Tampa, Florida, and Department of Anatomy, Louisiana State University, New Orleans, Louisiana

PLATFORM SESSION 111-B Colwood (F), 10.45 A.M.-12:15 P.M. METABOLISM Mont R. Juchau, Chair 10:45

86 IDENTIFICATION AND QUANTITATION OF 13-CIS-RETINOIC ACID AND 13-CIS-4-OXORETINOIC ACID IN ADDITION TO ALL-TRANS-RETINOIC ACID AS METABOLITES OF VITAMIN A IN HUMAN PLASMA. EckhofP, C. and H. Nau, Institut fur Toxikologie und Embryopharmakologie, Freie Universitat Berlin, FRG

11:oo

87 STRUCTURE-TERATOGENICITY RELATIONSHIPS OF VALPROIC ACID AND RELATED a-BRANCHED CARBOXYLIC ACIDS. Hauck", R.-S. and H. Nau, Institut fur Toxikologie und Embryopharmakologie, Freie Universitat Berlin, FRG

11:15

88 LACK OF ATTENUATION OF VALPROATE-INDUCED NEURAL TUBE

DEFECTS BY FOLINIC ACID IN RAT EMBRYOS IN VITRO. Hansen, D.K. and T.F. Grafton*, Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 11:30

89 PROTECTION FROM PHENYTOIN-INDUCED MALFORMATIONS IN A MOUSE MODEL. Finnell, R.H., P.L. Ager*, R.L. Steward*, and R.H. Levy*, Department of VCAPP, Washington State University, Pullman, Washington and (RHL) Department of Pharmaceutics, University of Washington, Seattle, Washington

11:45

90 INHIBITION OF PHENYTOIN METABOLISM BY CARBAMEZEPINE AND VALPROIC ACID. Delp", C., D. Delimont", and B. Buehler, Meyer Rehabilitation Institute, University of Nebraska Medical Center, Omaha, Nebraska

12:oo

91 ROLE OF ALDEHYDE DEHYDROGENASE IN DETOXIFICATION OF

CYCLOPHOSPHAMIDE (CP) IN POSTIMPLANTATION RAT EMBRYOS. Little, S.A., A. Ellison*, and P.E. Mirkes, Department of Pediatrics, University of Washington, Seattle, Washington


517

PLATFORM SESSION 111-C Oak Bay (B), 10:45 A.M.-12:15 P.M. CELL INJURY J o h n M. DeSesso, Chair 10:45

92 CELL-CYCLE ALTERATIONS, CELL DEATH AND TERATOGENESIS INDUCED IN MOUSE EMBRYOS BY 2-DEOXY-5-AZACYTIDINE (D-AZA). Rogers, J.M., B.M. Francis, K.K. Sulik, A.J. Alles, K.H. Elstein*, R.M. Zucker*, E.J. Massaro, M.R. Rosen*, and N. Chernoff, U.S. E.P.A. Health Effects Research Laboratory and NSI Technology, Research Triangle Park, and Dept. of Cell Biology and Anatomy, University of North Carolina School of Medicine, Chapel Hill, North Carolina

11:oo

93 PATTERNS O F EXCESSIVE CELL DEATH IN MOUSE EMBRYOS AND THEIR RELATIONSHIP TO ALCOHOL-RELATED BIRTH DEFECTS. Kotch*, L.E.', W.S. Webster and K.K. Sulik', 'Department of Cell Biology and Anatomy, University of North Carolina, Chapel Hill, North Carolina and 'Department of Anatomy, University of Sydney, Australia

'

11:15

94 EFFECT OF 4 - 0 0 H CYCLOPHOSPHAMIDE (4-OOH-CP) AND 4-00H-

DECHLOROCYCLOPHOSPHAMIDE (4-00H-deC1CP) ON THE CELL CYCLE OF POST-IMPLANTATION RAT EMBRYOS. Little, S.A. and P.E. Mirkes, Department of Pediatrics, University of Washington, Seattle, Washington 11:30

95 CADMIUM FAILS TO INDUCE TOLERANCE TO HEAT IN MOUSE EMBRYOS IN VITRO. Kapron-Bras, C.M. and B.F. Hales, Department of Pharmacology and Therapeutics, Centre for the Study of Reproduction, McGill Univer-

sity, Montreal, Canada 11:45

96 POTENTIAL MECHANISTIC DIFFERENCES BETWEEN TERATOGENS IN THE PATHOGENESIS OF ENVIRONMENTALLY INDUCED NEURAL TUBE DEFECTS. Finnell, R.H., R.L. Steward*, M. Englen* and P.L. Ager*, Department of VCAPP, Washington State University, Pullman, Washington

12:oo

97 CORRELATION OF ALTERED SOMITE MORPHOLOGY WITH EFFECTS OF HEAT STRESS ON THE RAT AXIAL SKELETON. Cuff, J.M.*, Thiel College, Greenville, Pennsylvania, C.A. Kimmel and G.L. Kimmel, EPA, Washington, D.C., D.J. Heredia*, BIOCON, and N.T. Brown*, FDA, Rockville, Maryland

PLATFORM SESSION 111-D Sidney (Ej, 10:45 A.M.-12:15 P.M. BIOCHEMICAL DIFFERENTIATION Thomas B. Knudsen, Chair 10:45

98 ALTERED PATTERN O F CELL ADHESION MOLECULE DISTRIBUTION IN NEURAL TUBES OF SPLOTCH MOUSE EMBRYOS. Moase, C.E. and D.G. Trader, Department of Biology and Centre for Human Genetics, McGill University, Montreal, Quebec

11:oo

99 GROWTH FACTOR INTERACTIONS REGULATING GLYCOSAMINOGLYCAN SYNTHESIS BY MESENCHYMAL CELLS OF THE MURINE EMBRYONIC PALATE. D'Angelo, M. and R.M. Greene, Department of Anatomy, Jefferson Medical College, Philadelphia, Pennsylvania

518


11:15

100 IDENTIFICATION OF CAMP DEPENDENT PROTEIN KINASE SUBSTRATES IN DEVELOPING OROFACIAL TISSUE. Weston, W.M." and R.M. Greene, Department of Anatomy, Jefferson Medical College, Philadelphia, Pennsylvania

11:30

101 TREATMENT OF MOUSE LIMB MESENCHYME WITH B-GALACTOSIDASE OR N-ACETYL-B-D-GLUCOSAMINIDASE SUPPRESSES IN VITRO CHONDROGENESIS. Elmer, W.A., S. Pollard*, and J.D. Cochran", Department of Biology, Emory University, Atlanta, Georgia

11:45

102 MODULATION OF CHONDROGENIC ACTIVITY OF CHICK EMBRYONIC CALVARIAL CELLS IN VITRO. Wong*, M. and R.S. Tuan" (Introduced by R.M. Greene), Graduate Program in Developmental BiologyiTeratology and Dept. of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania

12:oo

103 THE EFFECTS OF ALBENDAZOLE AND ALBENDAZOLE SULFOXIDE ON CULTURES OF DIFFERENTIATING RAT EMBRYO LIMB BUD CELLS. Whittaker*, S.G., M.R. Seeley" and E.M. Faustman, Departments of Pathology and Environmental Health, University of Washington, Seattle, Washington

POSTER SESSION I1 Saanich (A), 8:OO P.M.-9:30 P.M. (Posters should be set up after 1:00 P.M. Sunday a n d removed by midnight; Numbers P104-Pl38 should be attended from 8:OO P.M.-8:45 P.M. a n d Numbers P139-P171 attended from 8:45 P.M.-9:30 P.M.) Refreshments Available P104 DEVELOPMENTAL TOXICOLOGY OF LY201116 IN RATS AND RABBITS. Higdon", G.L., E.R. McKinley", and J.K. Markham. Toxicology Division, Lilly Research Laboratories, Eli Lilly and Co., Greenfield, Indiana P105 ASSESSMENT OF A DROSOPHILA-BASED SCREEN FOR DEVELOPMENTAL TOXICANTS. Davis", D.G., D.W. Lynch*', R.L. Schuler*', and R.D. Hood, Department of Biology, The University of Alabama, Tuscaloosa, Alabama, and 'NIOSH, Division of Biomedical and Behavioral Science, Experimental Toxicology Branch, Cincinnati, Ohio P106 INHIBITION OF INTERCELLULAR COMMUNICATION IN V79 CELLS BY DEVELOPWillington, and W. MENTAL TOXICANTS. Toraason, M., J.S. Bohrman, E. Kreig, R.D. Combs, S.E. Zajak (Introduced by B.K. Nelson), National Institute for Occupational Safety and Health, Cincinnati, Ohio; and Inveresk Research International, Ltd., Musselburgh, Scotland P107 EMBRYOTOXICITY, METABOLISM AND TISSUE ACCUMULATION OF QA208-199 IN VITRO CAN BE MODIFIED BY THE USE OF THE CYTOCHROME-P450 ENZYME INDUCERS AROCLOR 1254, PHENOBARBITAL AND 3-METHYLCHOLANTHRENE. Bechter, R. and G.D.C. Terlouw, Drug Safety Assessment, Sandoz Pharma Ltd., and Department of Toxicology, Sandoz A g o Ltd., Base1 P108 BIOTRANSFORMATION IN POST-IMPLANTATION RAT EMBRYO CULTURE USING MATERNAL HEPATOCYTES IN SUSPENSION COCULTURE. Piersma, A.H., L.A.G.J.M. Van Aerts", A. VerhoeP, J.E. Robinson*, and P.W.J. Peters, Departments of Teratology and Pathology, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands P109 SOME FUNDAMENTAL PROBLEMS WITH IN VITRO DEVELOPMENTAL TOXICITY PRESCREENING ASSAYS AS ILLUSTRATED WITH BEAN SEEDLINGS. Johnson, E.M., L.M. Newman and R.L. Giacobbi*, Daniel Baugh Institute, Jefferson Medical College, Philadelphia, Pennsylvania


519

PllO THE IN VITRO EMBRYOTOXICITY OF GENTIAN VIOLET IN PREIMPLANTATION MOUSE EMBRYOS. Buttar, H.S., J.H. Moffatt", C. Bura" and J . St-Vil", Bureau of Drug Research, Health Protection Branch, Ottawa, Ontario, Canada P l l l OPTIMIZATION OF THE CHICK EMBRYO RETINA CELL ASSAY TO SCREEN TERATOGENS. Fitzgerald", M.P., G.P. Daston, and E. Elmore", NSI Technology Services Corporation, Research Triangle Park, North Carolina and The Procter and Gamble Company, Cincinnati, Ohio P112 USING RAT HEPATOCYTES, UNINDUCED AND INDUCED RAT S-9, AND HUMAN S-9 FOR METABOLIC ACTIVATION IN THE FETAL MOUSE SALIVARY GLAND CULTURE SYSTEM. Lyng, R.D., R. Scalf and D. Monteith, Department of Biological Sciences, Indiana UniversityPurdue University, Fort Wayne, Indiana P113 EFFECTS OF TAMOXIFEN ON NEONATAL RAT UTERINE LUMINAL EPITHELIUM GROWTH IN VITRO. Branham, W.S., B.D. Lyn-Cook", C.R. L ~ t t l e " ~A., A n d r e ~ s " ~and , D.M. Sheehan', Divisions of Reproductive and Developmental Toxicology' and Comparative Toxicology2, and Pathology Associates, I ~ c .National ~, Center for Toxicological Research, DHHSIFDA, Jefferson, Arkansas and Department of Obstetrics and Gynecology3, University of Pennsylvania, Philadelphia, Pennsylvania P114 AN EVALUATION OF FOOD FLAVORING INGREDIENTS USING AN IN VIVO REPRODUCTIVE AND DEVELOPMENTAL TOXICITY SCREENING TEST. Vollmuth", T.A., M.B. Bennett*, A.M. Hoberman, and M.S. Christian, Lorillard Tobacco Company, Greensboro, North Carolina, and Argus Research Laboratories, Inc., Horsham, Pennsylvania P115 DEVELOPMENTAL TOXICITY EVALUATION OF SEVERAL COSMETIC INGREDIENTS IN THE HYDRA ASSAY. Newman, L.M., E.M. Johnson, R.L. Giacobbe" and L-J. FuX,Daniel Baugh Institute, Jefferson Medical College, Philadelphia, Pennsylvania P116 IN VITRO DEVELOPMENTAL TOXICITY SCREENING OF A COMPLEX MIXTURE WITH THE HYDRA ASSAY: SMOKELESS TOBACCO. Newman, L.M., E.M. Johnson, R. Paulsonl, T. Ly" and R.L. Giacobbe*, Daniel Baugh Institute, Jefferson Medical College, Philadelphia, Pennsylvania and 'College of Dentistry, Ohio State University, Columbus, Ohio P117 EFFECTS OF TRICHLOROETHYLENE IN AN IN VIVO DEVELOPMENTAL TOXICITY SCREEN. Narotsky, M.G.", M. Schlicht", E. Berman*, J.A. Elder", R.C. MacPhail", and R.J. Kavlock, NSI-Environmental Sciences and USEPA, Research Triangle Park, North Carolina P118 EFFECTS O F GESTATIONAL EXPOSURE TO 2,3,7,8-TETRACHLORODIBENZODIOXIN (TCDD) ON THYMIC LYMPHOCYTE POPULATIONS. Lindstrom, P., D. Germolec", C. Comment", M. Luster", and R. Morrissey, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina P119 MORPHOLOGIC AND IMMUNOLOGIC EFFECTS IN THE RAT OF PRENATAL EXPOSURE TO CYCLOPHOSPHAMIDE. Hessel, E.M.*, A. VerhoeP, A.H. Piersma, and P.W.J. Peters, Department of Teratology, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands P120 ADULT BEHAVIORAL STUDIES FOLLOWING PRENATAL 5.0 MHz ULTRASOUND EXPOSURE IN THE WISTAR RAT. Jensh, R.P., P.A. Lewin", B. Goldberg", M.K. Till", M.B. Eskesen", J . Oler* and R.L. Brent, Departments of Anatomy, Pediatrics, and Radiology, Jefferson Medical College of Thomas Jefferson University and Department of Electrical and Computer Engineering and Biomedical Engineering and Science Institute, Drexel University, Philadelphia, Pennsylvania P121 BEHAVIORAL OUTCOMES IN AGED WISTAR RATS EXPOSED PERINATALLY TO XIRRADIATION. Jensh, R.P., R.L. Brent, M.K. Till" and M.B. Eskesen", Departments of Anatomy, Pediatrics, and Radiology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania P122 THE EFFECTS OF PHENYTOIN ON OTOLITH MORPHOLOGY. Murakami", Y. and Y. Furukawa* (Introduced by M. Yasuda), Biological Research Laboratories, Lederle (Japan), Ltd., Shiki, Japan

520


P123 EFFECTS OF CHRONIC MATERNAL DEPRIVATION ON GROWTH AND DEVELOPMENT OF THE RAT. Lau, C.*, L.L. Antolick*, A.M. Cameron* and M.E. Stanton* (Introduced by R.J. Kavlock), NSI-ES and US EPA, Research Triangle Park, North Carolina P124 RETINOIC ACID ENHANCES CHONDROGENESIS OF MOUSE LIMB MESENCHYME IN SERUM-FREE CULTURES. Kwasigroch, T.E., C. Law* and H.J. Barrach, Department of Anatomy, East Tennessee State University, Johnson City, Tennessee and Department of Orthopaedics, Brown University School of Medicine, Providence, Rhode Island P125 SPECTRUM OF CARDIAC AND EXTRACARDIAC ANOMALIES INDUCED BY RETINOIC ACID IN RATS. Pexieder, T., M. Pfizenmaier Rousseile, and J.C. Prados Frutos*, Institut d'Histologie et d'Embryologie, Universite de Lausanne, Lausanne, Switzerland P126 EFFECTS OF 2-METHOXYETHANOL (2-ME) AND METHOTREXATE (MTX) ON PURINE POOLS AND CELL CYCLE OF MOUSE EMBRYOS. Stedman, D.B.* and F. Welsch, CIIT, Research Triangle Park, North Carolina P127 DOSE-RESPONSE RELATIONSHIPS IN CAFFEINE-MEDIATED POTENTIATION O F ACETAZOLAMIDE TERATOGENICITY AMONG C57 BLACK MICE. Beck, S.L., S.L. Kelich", and C.M. Urbano, Department of Biology, DePaul University, Department of Physiology and Health Sciences, and Department of Biology, Ball State University, Muncie, Indiana P128 HYDROXYUREA DEVELOPMENTAL TOXICITY IN RABBIT EMBRYOS IS AMELIORATED D-MANNITOL, A SPECIFIC SCAVENGER FOR HYDROXYL FREE RADICALS. DeSesso, J.M. and G.C. Goeringer", The MITRE Corporation, McLean, Virginia and Department of Anatomy and Cell Biology, Georgetown University School of Medicine, Washington, D.C. P129 DEVELOPMENT OF EXENCEPHALY IN MURINE FETUSES WITH CHROMOSOME IMBALANCE. Rutledge, J.C., M. Cunningham", T. Shepard, N.L.A. Cacheiro*, and W.M. Generoso*, Departments of Laboratory Medicine and Pediatrics, University of Washington School of Medicine, Seattle, Washington and Oak Ridge National Laboratories, Oak Ridge, Tennessee P130 THE PATTERN OF NEURAL TUBE DEFECTS CREATED BY SECONDARY REOPENING OF THE NEURAL TUBE. Campbell*, L.R. and G S . Sohal" (Introduced by T.F. Gale), Departments of Neurology and Anatomy, The Medical College of Georgia, Augusta, Georgia P131 PHENYLKETONURIA-RELATED METABOLITES OF PHENYLALANINE ARE EMBRYOTOXIC IN VITRO. Piersma, A.H., A. Verhoefr, E.H.J.M. Jansen", W.A. Van Den Ham", and P.W.J. Peters, Departments of Teratology and Toxicology, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands P132 THE POTENTIAL THERMAL IMPACT OF ULTRASOUND ON THE MACAQUE CONCEPTUS IN UTERO. Tarantal, A.F. and A.G. Hendrickx, California Primate Research Center, University of California, Davis, California P133 CNS DEVELOPMENT IN THE RAT EXPOSED TO IONIZING RADIATION DURING GESTATION. Persaud, T.V.N., J.E. Bruni and G. Froese*', Department of Anatomy and Manitoba Cancer Foundation', University of Manitoba, Winnipeg, Manitoba, Canada P134 SKELETAL DEVELOPMENT IN THE RAT FOLLOWING IN UTERO EXPOSURE TO ETHANOL AND ACETALDEHYDE. Fadel*, R.A. and T.V.N. Persaud, Department of Anatomy, University of Manitoba, Winnipeg, Canada P135 RETINOIC ACID INDUCED DEVELOPMENTAL TOXICITY IN THE FERRET MODEL. Juelch*, S., D. Raab", G. Batastini", E.T. Yau* and V.M. Traina;k (Introduced by K. Amemiya). CIBA-GEIGY Pharmaceuticals, Summit, New Jersey P136 EFFECT OF TERATOGENS ON MATERNAL CORTICOSTERONE LEVELS AND OROFACIAL CLEFT INCIDENCE. Sullivan Jones*, P., R.R. Holson*, S.R. Price*, D.M. Shehan, and D.H. Hansen, Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas


52 1

P137 EPITOPE ANALYSIS OF MONOCLONAL ANTIBODIES (MAbs) AGAINST VISCERAL YOLK SAC (VYS) ANTIGENS. Jensen, M., J.B. Lloyd and R.L. Brent, Department of Pediatrics, Thomas Jefferson University, Philadelphia, Pennsylvania, Alfred I. du Pont Institute, Wilmington, Delaware P138 DEVELOPMENTAL TOXICITY IN RABBITS OF THE ANTIFOLATE AMINOPTERIN AND ITS AMELIORATION BY LEUCOVORIN. Goeringer", G.C. and J.M. DeSesso, Department of Anatomy and Cell Biology, Georgetown University School of Medicine, Washington, D.C. and The MITRE Corporation, McLean, Virginia P139 EFFECTS OF DEXAMETHASONE (DEX) ON PRENATAL GROWTH AND DEVELOPMENT IN THE RAT. LaBorde, J.B., D.K. Hansen, D.M. Sheehan, and R.R. Holson*, Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas P140 NEW METHOD FOR EXPLANTING EARLY POSTIMPLANTATION RAT EMBRYOS FOR CULTURE. Fujinaga, M. and J.M. Baden, Department of Anesthesia, Stanford University School of Medicine, Stanford, California and Palo Alto V.A. Medical Center, Palo Alto, California P141 INTERLITTER VARIABILITY AND DEVELOPMENT OF DAY 11 RAT EMBRYOS PRODUCED BY OVERNIGHT AND MORNING SHORT-PERIOD BREEDING REGIMENS. Fujinaga, M., E.C. Jackson*, R.I. Mazze, and J.M. Baden, Dept. of Anesthesia, Stanford University School of Medicine, Stanford, California and Palo Alto V.A. Medical Center, Palo Alto, California P142 PREVENTIVE EFFECTS OF PHENOXYBENZAMINE (PX) AGAINST NITROUS OXIDE (N,O) INDUCED TERATOGENICITY IN SPRAGUE-DAWLEY RATS. Fujinaga, M., J.M. Baden, A. %to*, J.K. Myatt*, and R.I. Mazze, Department of Anesthesia, Stanford University School of Medicine, Stanford, California, and Palo Alto V.A. Medical Center, Palo Alto, California P143 AGE- AND DOSE-DEPENDENT TRANSPLACENTAL EFFECTS OF N-NITROSOETHYLUREA IN SYRIAN GOLDEN HAMSTERS. Diwan*, B.A., P.J. Donovan*, S. Rehm*, and J.M. Rice, BCDP, Program Resources, Inc., and Laboratory of Comparative Carcinogenesis, NCI-FCRF, Frederick, Maryland P144 LEFT-HANDED Z-DNA IMMUNOREACTIVITY IN ABNORMALLY DEVELOPED CALF LENS. Gagna, C.E. and O.G. Mitchell", Department of Anatomy, New York University Dental Center, New York, New York P145 MAMMARY PASSAGE OF RADIOACTIVITY IN SUCKLING RATS FROM MOTHERS TREATED WITH 3H-COCAINE AND ETHANOL. Buttar, H.S., J.H. Moffatt", and W.L. Wilson*, Bureau of Drug Research, Health Protection Branch, Ottawa, Canada P146 SELENIUM TRANSPORT IN THE PERFUSED HUMAN PLACENTA IN VITRO. Eisenmann", C.J. and R.K. Miller, Department of Obstetrics and Gynecology, Division of Toxicology, University of Rochester, Rochester, New York P147 EAR ABNORMALITIES IN THE FETAL HYDANTOIN SYNDROME. Hall, B.D., Department of Pediatrics, University of Kentucky, Lexington, Kentucky P148 RISKS FOR CONGENITAL CARDIAC ANOMALIES RELATIVE TO SELECTED MATERNAL EXPOSURES DURING EARLY PREGNANCY. Shaw, G.M.*, L.H. Malcoe", S.H. Swan", S.K. Cummins*, J. Schulman*, and J.A. Harris, California Birth Defects Monitoring Program, March of Dimes Birth Defects Foundation, Emeryville, California P149 ABNORMALITIES OF AMNIOTIC MEMBRANE IN THE EMBRYONIC PERIOD. McFadden", D.E., B. Paradice* and D.K. Kalousek, University of British Columbia, Vancouver, British Columbia P150 HUMAN SIRENOMELIA: SPECTRUM OF ABNORMALITIES IN FIVE CASES. Machin*, G.A., L.H. Honoe, and C.J. Curry*, Department of Pathology, University of Alberta, Edmonton, Alberta, Canada and Department of Medical Genetics, Valley Children's Hospital, Fresno, California

522


P151 MATERNAL WATER CONSUMPTION IN RELATION TO PREGNANCY LOSS IN HUMANS AND FISCHER AND SPRAGUE-DAWLEY RATS. Swan", S.H., C.L. Keen, J.Y. Uriu-Hare", and R.R. Neutra", California Department of Health Services, Berkeley, and Department of Nutrition, University of California, Davis, California P152 ORGAN GROWTH IN TRISOMY 21 FETUSES. Fitzsimmons, J., S. Droste", T. Shepard, and A. Fantel, Departments of Ob-Gyn and Pediatrics, University of Washington, Seattle, Washington P153 SPONTANEOUS ABORTION IN PREGNANCIES FOLLOWING OVULATION INDUCTION IN INFERTILE WOMEN: A REPORT OF 21 CASES. Honore, L.H. G.A. Machin", and C.C. Lin", Department of Pathology, University of Alberta, Edmonton, Alberta, Canada P154 NON-MOLAR TRIPLOIDY IN HUMAN ABORTUSES: A PATHOLOGIC STUDY OF 8 CASES. Honore, L.H., G.A. Machin", C.C. Lin", and C.J. Curry", Department of Pathology, University of Alberta, Edmonton, Alberta, Canada and Department of Medical Genetics, Valley Children's Hospital, Fresno, California P155 METHODOLOGY FOR ASSESSING SOMATIC AND VISCERAL GROWTH OF THE MIDGESTATION FETUS. Barr, M., Departments of Pediatrics, Pathology and Obstetrics, University of Michigan, Ann Arbor, Michigan P156 STANDARDS FOR ASSESSING SOMATIC AND VISCERAL GROWTH OF THE MIDGESTATION HUMAN FETUS. Barr, M., Departments of Pediatrics, Pathology and Obstetrics, University of Michigan, Ann Arbor, Michigan P157 PREDICTORS OF ORGAN WEIGHT IN TRISOMY 18 FETUSES. Droste", S., J. Fitzsimmons, and T. Shepard, Departments of Ob-Gyn and Pediatrics, University of Washington, Seattle, Washington P158 MINOR EYE ANOMALIES: AN OPHTHALMOLOGISTS VIEW. Miller, M.T., Department of Ophthalmology, University of Illinois a t Chicago Eye and Ear Infirmary, Chicago, Illinois P159 CARDIOMYOPATHY AND CARDIAC TUMORS IN INFANCY: AN EPIDEMIOLOGIC STUDY. Ferencz, C., C.A. Neill", and the Baltimore-Washington Infant Study (BWIS) Group, Department of Epidemiology and Preventive Medicine, Baltimore, Maryland P160 ARE HUMAN SEX DIFFERENCES IN RATES OF NON-SYNDROMIC BIRTH DEFECTS EXPLAINED BY SEX DIFFERENCES IN EMBRYOLOGIC MATURATION? Torfs", C.P., C.J. Curry", and L.H. Honore, California Birth Defects Monitoring Program, Emeryville, California, Medical Genetics, Valley Children's Hospital, Fresno, California, and University of Alberta, Edmonton, Aka, Canada P161 BIRTH ORDER AND OCCURRENCE OF TALIPES EQUINOVARUS IN HUMANS. Alderman, B.W. and E. Takahashi", Department of Epidemiology, University of Washington, Seattle, Washington P162 ACETAZOLAMIDE-INDUCED MICRODYSGENESIS IN THE CEREBRAL CORTEX OF THE MOUSE. Sherman", G.F., L.B. Holmes, and A.M. Galaburda", Beth Israel Hospital and Massachusetts General Hospital, Boston, Massachusetts P163 PRINCIPLES OF HAZARD IDENTIFICATION: A METHODOLOGY AND A MODEL. Jelovsek", F.R., D.R. Mattison, and J.F. Young, Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, and Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas PI64 DEVELOPMENTAL EFFECTS O F CHLOROACETIC ACID IN THE LONG-EVANS RAT. Smith, M.K., J.L. Randall+, E.J. Read"', and J.A. Stober", HERL, USEPA, 'PAI, and 'Computer Sciences Corporation, Cincinnati, Ohio P165 ABSORPTION AND DISTRIBUTION OF RADIOLABELED TRICHLOROACETONITRILE (TCAN) FROM TWO VEHICLES. Roth", A.C., D.A. Gordon" and M.K. Smith, HERL, USEPA, Cincinnati, Ohio


523

P166 A COMPARISON OF THE DEVELOPMENTAL EFFECTS OF TRICHLOROACETONITRILE (TCAN) IN TWO VEHICLES. Christ", S.A., E.J. Read*+, J.A. Stober*, and M.K. Smith, HERL, USEPA, +Computer Sciences Corporation, Cincinnati, Ohio P167 DEVELOPMENTAL TOXICITY STUDY OF OLEYLAMINE IN TWO SPECIES. Mercieca, M.D.', E.C. Bisinger'", J.M. Gerhart2, D.E. Rodwell', T.N. Memiman'*, 'Springborn Laboratories, Inc., Spencerville, Ohio and 'Akzo Chemicals, Inc., Chicago, Illinois P168 DEVELOPMENTAL TOXICITY STUDY OF 2-MERCAPTOBENZOTHIAZOLE (MBT) IN TWO SPECIES. Rodwell, D.E.l, J.M. Gerhart', E.C. Bisinger'", M.D. Mercieca', J.J. McKenziel*, 'Springborn Laboratories, Inc., Spencerville, Ohio, and 'Akzo Chemicals, Inc., Chicago, Illinois P169 DEVELOPMENTAL TOXICITY STUDY OF 2-HYDROXYPROPYL METHANETHIOLSULFONATE (HPMTS) IN RATS AND RABBITS. Adam, G.A.l, K.D. Drake2*, S.L. Helmhout2*, M.D. Mercieca', and J.J. McKenziel*, 'Springborn Laboratories, Inc., Spencerville, Ohio and 'Buckman Laboratories, Inc., Memphis, Tennessee P170 THE EFFECTS OF MATERNAL EXPOSURE TO VDT-LIKE MAGNETIC FIELDS THROUGHOUT PREGNANCY ON THE PRENATAL DEVELOPMENT OF CD-1 MICE. Wiley, M., D. Agnew*, S. Harvey*, M. Walsh* and P. Corey*, Departments of Anatomy and Preventive Medicine and Biostatistics, University of Toronto, and The Ontario Hydro Corporation, Toronto, Ontario P171 SUPERNUMERARY KIDNEYS INDUCED BY ACETAZOLAMIDE AND EXACERBATION BY AGENTS WHICH PERTURB TRANSCELLULAR ION MOVEMENT. Miller, T.W., C.M. Schreiner, and W.J. Scott, Children's Hospital Research Foundation, Cincinnati, Ohio

POSTER DISCUSSION SESSION 11-A Sidney (El, 9:45 P.M.-10:45 P.M. I N VITRO SCREENS Elaine M. Faustman, Chair P105 ASSESSMENT OF A DROSOPHILA-BASED SCREEN FOR DEVELOPMENTAL TOXICANTS. Davis et al. P106 INHIBITION OF INTERCELLULAR COMMUNICATION IN V79 CELLS BY DEVELOPMENTAL TOXICANTS. Toraason et al. P107 EMBRYOTOXICITY, METABOLISM AND TISSUE ACCUMULATION OF QA208-199 IN VITRO CAN BE MODIFIED BY THE USE OF THE CYTOCHROME-P450 ENZYME INDUCERS AROCLOR 1254, PHENOBARBITAL AND 3-METHYLCHOLANTHRENE. Bechter et al. P108 BIOTRANSFORMATION IN POST-IMPLANTATION RAT EMBRYO CULTURE USING MATERNAL HEPATOCYTES IN SUSPENSION COCULTURE. Piersma et al. P l l l OPTIMIZATION OF THE CHICK EMBRYO RETINA CELL ASSAY TO SCREEN TERATOGENS. Fitzgerald et al. P109 SOME FUNDAMENTAL PROBLEMS WITH IN VITRO DEVELOPMENTAL TOXICITY PRESCREENING ASSAYS AS ILLUSTRATED WITH BEAN SEEDLINGS. Johnson et al.

POSTER DISCUSSION 11-B Colwood (F), 9:45 P.M.-10:45 P.M MECHANISMS Don R. Hilbelink, Chair P125 SPECTRUM OF CARDIAC AND EXTRACARDIAC ANOMALIES INDUCED BY RETINOIC ACID IN RATS. Pexieder et al.

524


P126 EFFECTS OF 2-METHOXYETHANOL (2-ME) AND METHOTREXATE (MTX) ON PURINE POOLS AND CELL CYCLE OF MOUSE EMBRYOS. Stedman et al. P127 DOSE-RESPONSE RELATIONSHIPS IN CAFFEINE-MEDIATED POTENTIATION O F ACETAZOLAMIDE TERATOGENICITY AMONG C57 BLACK MICE. Beck et al. P128 HYDROXYUREA DEVELOPMENTAL TOXICITY IN RABBIT EMBRYOS IS AMELIORATED D-MANNITOL, A SPECIFIC SCAVENGER FOR HYDROXYL FREE RADICALS. DeSesso et al. P129 DEVELOPMENT OF EXENCEPHALY IN MURINE FETUSES WITH CHROMOSOME IMBALANCE. Rutledge et al. P130 THE PATTERN OF NEURAL TUBE DEFECTS CREATED BY SECONDARY REOPENING OF THE NEURAL TUBE. Campbell et al.

POSTER DISCUSSION SESSION 11-C Esquimalt (C), 9:45 P.M.-10:45 P.M. CLINICAL J a i m e L. Frias, Chair P147 EAR ABNORMALITIES IN THE FETAL HYDANTOIN SYNDROME. Hall P148 RISKS FOR CONGENITAL CARDIAC ANOMALIES RELATIVE TO SELECTED MATERNAL EXPOSURES DURING EARLY PREGNANCY. Shaw e t al. P159 CARDIOMYOPATHY AND CARDIAC TUMORS IN INFANCY: AN EPIDEMIOLOGIC STUDY. Ferencz et al. P156 STANDARDS FOR ASSESSING SOMATIC AND VISCERAL GROWTH OF THE MIDGESTATION HUMAN FETUS. Barr P152 ORGAN GROWTH IN TRISOMY 21 FETUSES. Fitzsimmons et al. P153 SPONTANEOUS ABORTION IN PREGNANCIES FOLLOWING OVULATION INDUCTION IN INFERTILE WOMEN: A REPORT OF 21 CASES. Honore e t al.

MONDAY, JUNE 11 SYMPOSIUM V

Theatre, 8:OO A.M.-10:05 A . M . CELL-CELL INTERACTION George P. Daston, Chair 8:OO-8:05

OPENING REMARKS. George P. Daston, The Procter and Gamble Co., Cincinnati, Ohio

8:05-8:45

CELL-CELL INTERACTIONS IN DEVELOPMENT. Kathryn M. Tosney, Department of Biology, University of Michigan, Ann Arbor, Michigan

8:45-9:25

ADHESION, MOTILITY AND INVASIVENESS OF TRANSFORMED NEUROEPITHELIAL CELLS. Robert W. Brackenbury, Department of Anatomy and Cell Biology, University of Cincinnati, Cincinnati, Ohio


525

9:25-10:00

THE ROLE OF CELL ADHESION MOLECULES, THE EXTRACELLULAR MATRIX AND CELL PROLIFERATION IN AVIAN SCALE DEVELOPMENT. Roger H. Sawyer, Department of Biological Science, University of South Carolina, Columbia, South Carolina

10:05-10:30

BREAK PLATFORM SESSION IV-A

Sidney (E), 10:30 A.M.-12:OO P.M DYSMORPHOLOGY - DRUGS O F ABUSE Michael F. Greene, Chair 10:30

172 BRAIN HEMORRHAGES IN COCAINE-EXPOSED FETUSES. Shaw, CM., T.H. Shepard, and R.P. Kapur*, Departments of Pathology and Pediatrics, University of Washington Medical School, Seattle, Washington

10:45

173 TWINS OF ALCOHOLIC MOTHERS: CONCORDANCE AND DISCORDANCE FOR FAS, GROWTH AND I&. Streissguth, A.P. and Ph. Dehaene", Department of Psychiatry, University of Washington, Seattle, Washington, and Hopital la Fraternite, Unite de Neonatologie, Roubaix, France

11:oo

174 CRANIOFACIAL ANATOMY OF RETINOIC ACID EMBRYOPATHY. Siebert, J.R. and E.J. Lammer, Department of Pathology, Children's Hospital and Medical Center and University of Washington, Seattle, Washington and California Birth Defects Monitoring Program, Berkeley, California

11:15

175 HISTORY OF GESTATIONAL HYPERTHERMIA IN TWO PATIENTS WITH AMYOPLASIA. Edwards*, M.J., J.B. Moeschler, M. Fahy*, J.G. Hall, and J.M. Graham, Jr., Medical Genetics-Birth Defects Center, Ahmanson Pediatric Center, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, California; Dept. of Maternal and Child Health, Dartmouth Medical School, Hanvover, New Hampshire; Dept. of Medical Genetics, University of British Columbia; Vancouver, British Columbia, Canada

11:30

176 FETAL EFFECTS OF ANGIOTENSIN CONVERTING ENZYME INHIBITOR. Barr, M. Departments of Pediatrics, Pathology and Obstetrics, University of Michigan, Ann Arbor, Michigan

11:45

177 THALIDOMIDE EMBRYOPATHY: A CLUE TO THE TIMETABLE FOR SOME OCULAR ANOMALIES. Miller, M.T., Department of Ophthalmology, University of Illinois a t Chicago Eye and Ear Infirmary, Chicago, Illinois

PLATFORM SESSION IV-B Colwood (F), 10:30 A.M.-12:OO P.M. EARLY EMBRYO Thomas W. Sadler, Chair 10:30

178 RAPID ACCUMULATION OF ADENOSINE IN THE MOUSE GESTATION SITE FOLLOWING IN UTERO EXPOSURE TO DEOXYCOFORMYCIN. Knudsen, T.B., S.K. Otey", R.S. Winters", M.R. Blackburn", and R.G. Skalko, Department of Anatomy, East Tennessee State University, Johnson City, Tennessee

10:45

179 INCREASED ADENOSINE CONTENT IN THE EARLY POSTIMPLANTATION MOUSE EMBRYO-DECIDUA FOLLOWING EXPOSURE TO DEOXY-

526


COFORMYCIN IN VITRO. Blackburn", M.R., R.G. Skalko, J.K. Church", and T.B. Knudsen, Department of Anatomy, East Tennessee State University, Johnson City, Tennessee 11:oo

180 DEVELOPMENTAL TOXICITY OF SERTRALINE, A SELECTIVE SEROTONIN UPTAKE INHIBITOR IN MOUSE WHOLE EMBRYO CULTURE. Shuey", D.L., T.W. Sadler and J.M. Lauder", Curr. in Toxc. and Dept. of Cell Biol. and Anat., Univ. of North Carolina, Chapel Hill, North Carolina

11:15

181 METHIONINE AND NEURAL TUBE CLOSURE IN CULTURED RAT EMBRYOS. Coelho, C.N.D. and N.W. Klein, Center for Environmental Health, University of Connecticut, Storrs, Connecticut

11:30

182 PHENYLKETONIC INDUCED EMBRYOPATHIES IN MOUSE EMBRYOS IN CULTURE. Denno, K.M." and T.W. Sadler, Department of Cell Biology and Anatomy, University of North Carolina, Chapel Hill, North Carolina

11:45

183 ASYMMETRIC DYSMORPHOGENESIS INDUCED BY HYPEROXIA IN RAT EMBRYO CULTURE. Fantel, A.G., C.J. Burroughs-Gleim", and R.E. Person", Department of Pediatrics, University of Washington, Seattle, Washington

PLATFORM SESSION IV-C Esquimalt (C), 10:30 A.M.-12:OO P.M. MATERNAL EFFECTS J o h n M. Rogers, Chair 10:30

184 POTENTIAL ROLE OF MATERNAL METALLOTHIONEIN INDUCTION IN DEVELOPMENTAL TOXICITY. Daston, G.P., G.J. Overmann", L.D. Lehman-McKeeman", J.M. Rogers, M.W. Taubeneck", and C.L. Keen, Procter and Gamble, Cincinnati, Ohio, U S. EPA, Research Triangle Park, North Carolina and Univ. California, Davis, California

10:45

185 65Zn METABOLISM DURING PREGNANCY IN THE RAT: EFFECT OF DIABETES AND INSULIN THERAPY. Uriu-Hare':, J.Y., R.M. Walter", and C.L. Keen, Department of Nutrition, University of California, Davis, California

11:oo

186 CORRELATION OF PHTHALATE-INDUCED EMBRYOTOXICITY WITH MATERNAL IN VIVO AND IN VITRO OVARIAN FUNCTION. Gray*, L.E., Jr., J . Laskey", J . Ostby", and E.R. Sigmon", (Introduced by J.A. Gray), USEPA, HERL, DTD, RTB, Developmental Reproductive Biology Section, Research Triangle Park, North Carolina

11:E

187 DECIDUAL NECROSIS AND MATERNAL PERITONITIS AS POSSIBLE CONTRIBUTORY FACTORS IN CADMIUM CHLORIDE-INDUCED RESORPTIONS AND MALFORMATIONS UPON I P DOSING O F RATS. Khera, K.S., Bureau of Chemical Safety, Food Directorate, Ottawa, Canada

11:30

188 THE ROLE OF MATERNAL VARIATION IN THE ASSESSMENT OF DEVELOPMENTAL TOXICITY. Hassett-Sipple, B.M.", J.M. Rogers, B.M. Francis, T.R. Logsdon", and N. Chernoff, University of North Carolina School of Public Health, Chapel Hill, U S . E.P.A. Health Effects Research Laboratory and NSI, Research Triangle Park, North Carolina

11:45

189 DEVELOPMENTAL TOXICITY STUDIES OF IMIPENEMXILASTATIN SODIUM IN MONKEYS. Cukierski, M.A., L.D. Wise, R. Korte"", J.S. MacDonald", R.T. Robertson, and A.G. Hendrickxb, Dept. of Safety Assessment, Merck Sharp and Dohme Res. Lab., West Point, Pennsylvania; Hazleton Lab.


527

Deutschland GmbHa, Munster, W. Germany; and California Primate Research Centerb, U of California, Davis, California PLATFORM SESSION IV-D Theatre, 10:30 A.M.-12:OO P.M. GENE EXPRESSION Zahra F. Zakeri, Chair 10:30

190 PATTERNS OF CYCLIC AMP-DEPENDENT PROTEIN KINASE GENE EXPRESSION DURING ONTOGENY OF THE MURINE SECONDARY PALATE. Greene R.M.' and M.M. Pisano', Dept. Anatomy, Jefferson Medical College, Philadelphia, Pennsylvania' and Lab. Molec. and Devel. Biol. NEI, NIH, Bethesda, Maryland'

10:45

191 MOLECULAR CLONING AND PROMOTER ANALYSIS OF THE GENE ENCODING THE LENS MAJOR INTRINSIC PROTEIN (MIP). Pisano, M.M. and A.B. Chepelinsky", Laboratory of Molecular and Developmental Biology, National Eye Institute, NIH, Bethesda, Maryland

11:oo

192 ALTERATIONS IN TGF,, GENE EXPRESSION DURING DEVELOPMENT OF THE MURINE PALATE. Gehris, A.L. and R.M. Greene, Department of Anatomy, Jefferson Medical College, Philadelphia, Pennsylvania

11:15

193 TCDD ALTERS THE EXPRESSION OF GROWTH FACTORS IN THE EMBRYONIC MOUSE PALATE. Abbott, B.C. and L.S. Birnbaum, NTP, NIEHS; Research Triangle Park, North Carolina

11:30

194 EXPRESSION OF DIFFERENTIATED CHARACTERISTICS IN RODENT EMBRYO CENTRAL NERVOUS SYSTEM CELL CULTURES: EFFECTS OF TERATOGEN EXPOSURE. Sweeney*, C. and E.M. Faustman, Dept. of Environmental Health, Univ. of Washington, Seattle, Washington

11:45

195 DEVELOPMENTAL REGULATION OF THE HEAT SHOCK RESPONSE IN POSTIMPLANTATION RAT EMBRYOS. Mirkes, P.E. and R. Grace", Department of Pediatrics, University of Washington, Seattle, Washington

12:oo-200

COUNCIL I1 LUNCH - Langford fG) SYMPOSIUM VI Theatre, 1:30 PM-3:30 P.M. GENETIC FACTORS IN EARLY HUMAN EMBRYOGENESIS J a m e s W. Hanson, Chair

1:30-2:10

PRINCIPLES FOR ECOGENETIC INVESTIGATION OF HUMAN TERATOGENESIS. Gilbert S. Omenn, School of Public Health and Community Medicine, University of Washington, Seattle, Washington

2:lO-2:50

MOLECULAR AND DEVELOPMENTAL BIOLOGY OF GROWTH FACTORS IN EARLY CRANIOFACIAL MORPHOGENESIS. Mark Ferguson, Department of Cell and Structural Biology, University of Manchester, Manchester, England

2:50-3:30

IS GENOMIC IMPRINTING RELEVANT FOR HUMAN DEVELOPMENT? JUdith G. Hall, Department of Medical Genetics, University of British Columbia, Vancouver, B.C., Canada

3:30

BREAK

528


PLATFORM SESSION V-A Theatre, 3:45 P.M.-5:30 P.M. EPIDEMIOLOGY - POTPOURRI Godfrey P. Oakley, Jr., Chair 3:45

196 QUALITY CONTROL OF BIRTH DEFECT REGISTRY DATA: A CASE STUDY. Schulman", J . and J.A. Harris, California Birth Defects Monitoring Program, March of Dimes Birth Defects Foundation, Emeryville, California

4:OO

197 NEW EVIDENCE THAT DERMAL RIDGE PATTERNS ARE NOT GENETICALLY DETERMINED. Roberts. R.M., Genetics and Dysmorphology Services, T.C. Thompson Children's Hospital, Chattanooga, Tennessee

4:15

198 CONOTRUNCAL MALFORMATIONS AND THE diGEORGE SYNDROME: THE NEED FOR BIOLOGIC MARKERS IN EPIDEMIOLOGIC STUDIES. Ferencz, C., Department of Epidemiology and Preventive Medicine and the Baltimore-Washington Infant Study (BWIS) Group, Baltimore, Maryland

4:30

199 ACCUTANE EXPOSURE IN PREGNANCY-A NOVEL SURVEY DESIGN. Mitchell, A.A., C. Louik", and D.M. Gute", Slone Epidemiology Unit, B.U. School of Public Health, Boston, Massachusetts

4:45

200 PROSPECTIVE FOLLOW-UP OF OFFSPRING BORN TO WOMEN INFECTED WITH VARICELLA DURING PREGNANCY. Jones, K.L., K.A. Johnson" and T.A. Chambers, Department of Pediatrics, Division of Dysmorphology, University of California San Diego, La Jolla, California

5:OO

201 RISK FACTORS FOR BIRTH DEFECTS AMONG CHINESE CHILDREN. Li'$,D.K. (Introduced by B. Alderman), Department of Epidemiology, University of Washington, Seattle, Washington

5:15

202 COUNSELING PATIENTS AND PHYSICIANS ABOUT THE REPRODUCTIVE RISKS OF PRIOR (PRECONCEPTION) CANCER THERAPY. Brent, R.L., Department of Pediatrics, Jefferson Medical College, Philadelphia, Pennsylvania and A.I. duPont Institute, Wilmington, Delaware

PLATFORM SESSION V-B Sidney (E), 3:45 P.M.-5:15 P.M. DRUGS O F ABUSE Kathleen K. Sulik, Chair 3:45

203 MATERNAL CARDIO-TOXICITY OF COCAINE: A RAT MODEL. Sharma", A,, R.K. Miller, C. Liang", D. Sherer" and J.R. Woods", Depts. of ObstetricsiGynecology and Medicine, University of Rochester, Rochester, New York

4:OO

204 DIRECT EMBRYOTOXICITY OF COCAINE IN RATS: EFFECTS ON MITOCHONDRIAL ACTIVITY, CARDIAC FUNCTION AND GROWTH AND DEVELOPMENT IN VITRO. Fantel, A.G., C.J. Burroughs-Gleim", B. Mackler and R.E. Person*, Department of Pediatrics, University of Washington, Seattle, Washington

4:15

205 DEVELOPMENTAL EFFECTS OF COCAINE. Hunter*', E.S., K.K. Sulik', R.C. Cefalo"*, and T.W. Sadler', 'Dept. Cell Biol. and Anatomy, Dept. Obstet. and Gynecol., Univ. North Carolina, Chapel Hill, North Carolina


529

4:30

206 TERATOGENIC EFFECTS O F COCAINE ON THE CENTRAL NERVOUS SYSTEM OF CHICKEN EMBRYOS. Eisner”, S.I., J. Singh*, and S.H. Gilani, Departments of Anatomy, New York University, New York City and University of Medicine and Dentistry of New Jersey, Newark, New Jersey

4:45

207 HOLOPROSENCEPHALY WITH MEDIAN CLEFT LIP AND PALATE IN A FETAL MACAQUE FOLLOWING WEEKLY EXPOSURE TO ETHANOL. Siebert, J.R., S.J. Astley*, and S.K. Clarren, Departments of Pathology and Pediatrics and Regional Primate Center, University of Washington, Seattle, Washington

5:OO

208 CORTICAL VASCULAR DAMAGE AND ASTROGLIAL REACTIONS INDUCED BY BINGE EXPOSURE TO ALCOHOL DURING THE BRAIN GROWTH SPURT. Goodlett”, C.R. and J.R. West, Department of Anatomy, University of Iowa, Iowa City, Iowa

PLATFORM SESSION V-C Colwood (F), 3:45 P.M.-5:15 P.M.

LIMB DYSMORPHOGENESIS Richard G. Skalko, Chair 3:45

209 SYNERGISTIC TERATOGENICITY OF THE INDUSTRIAL SOLVENT 2METHOXYETHANOL (2ME) AND RADIOFREQUENCY (RF) RADIATION IN RATS. Nelson, B.K., D.L. Conover, W.S. Brightwell, P.B. Shaw, D. Werren, R.M. Edwards, and J.M. Lary, NIOSH, Cincinnati, Ohio

4:OO

210 DIFFERENTIAL TARGETS O F METHOTREXATE IN RABBIT LIMB BUDS: EARLY CHANGES OCCUR IN MESENCHYMAL CELLS BUT NOT IN ENDOTHELIAL CELLS. DeSesso, J.M., D.R. Farmer, D.M. Nelson*, C.B. Underhill*, and G.C. Goeringer*, The MITRE Corporation, McLean, Virginia; Washington University, St. Louis, Missouri; and Georgetown University, Washington, D.C.

4:15

211 MARMOSETS AS A CONVENIENT PRIMATE SPECIES FOR STUDIES IN REPRODUCTIVE BIOLOGY AND TOXICOLOGY. Neubert, D., W. Heger, S. Klug*, H-J Merker, Institut fur Toxikologie und Embryopharmakologie, Freie Universitat Berlin, FRG

4:30

212 ESTIMATION OF INTRACELLULAR pH (pHJ BY COMPUTER ASSISTED IMAGERY. Schreiner, C.M., W.J. Scott, M. Namovic, and D. McCandless, Children’s Hospital Research Foundation, Cincinnati, Ohio and Chicago Medical School, North Chicago, Illinois

4:45

213 EXACERBATION OF ACETAZOLAMIDE TERATOGENESIS BY COADMINISTRATION OF PROTON PUMP INHIBITORS. Scott, W., C. Schreiner, and M. Collins, Children’s Hospital Research Foundation, Cincinnati, Ohio

5:OO

214 H+-ATPase: A POSSIBLE REGULATOR OF pH, IN THE DEVELOPING LIMB. Bennett, G. and W. Scott, Children’s Hospital Research Foundation, Cincinnati, Ohio

530


PLATFORM SESSION V-D Esquimalt (C), 3:45 P.M.-5:15 P.M. DEVELOPMENTAL TOXICOLOGY Allen S. Goldman, Chair 3:45

215 ABNORMAL DEVELOPMENT OF MALE UROGENITAL SINUS DERIVATIVES PRODUCED BY A 5ALPHA-REDUCTASE INHIBITOR. Wier, P.J., M. Canner*, and C.M. Johnson*, Smith Kline and French Laboratories, Philadelphia, Pennsylvania

4:OO

216 5a-REDUCTASE INHIBITOR-INDUCED CONGENITAL ABNORMALITIES IN MALE RAT EXTERNAL GENITALIA. Clark, R.L., C.A. Anderson*, S. Prahalada, Y.M. Leonard*, J.L. Stevens, and A.M. Hoberman, Merck Sharp and Dohme Research Laboratories, West Point, Pennsylvania and Argus Research Laboratories, Horsham, Pennsylvania

4:15

217 REVERSIBLE EFFECTS ON EXTERNAL GENITALIA IN RATS EXPOSED IN UTERO TO TRIAMCINOLONE ACETONIDE. Wise, L.D., C.V. Vetter*, C.A. Anderson*, J.M. Antonello*, and R.L. Clark, Department of Safety Assessment, Merck Sharp and Dohme Research Laboratories, West Point, Pennsylvania

4:30

218 EFFECTS OF A PRENATAL BRAIN INJURY ON POSTNATAL BODY WEIGHT AND PITUITARY WEIGHT. Rodier, P.M., Department of Obstetrics and Gynecology, University of Rochester, Rochester, New York

445

219 ADVERSE EFFECTS OF HALOTHANEINZO-MIXTURES ON POSTNATAL DEVELOPMENT OF RATS. Koeter, H.B.W.M., TNO-CIVO Toxicology and Nutrition Institute, Zeist, The Netherlands

5:OO

220 BEHAVIORAL AND NEUROCHEMICAL EFFECTS OF METHYLENEDIOXYMETHAMPHETAMINE (MDMA) WHEN ADMINISTERED DURING LATE GESTATION IN THE RAT. Broening*, H.W., 111,G.D. Newport*, S.F. Ali”, and W. Slikker, Jr., Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, and Division of Interdisciplinary Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas

6:30-1O:OO

RECEPTION AND BANQUET - Salon (AIBI

TERATOLOGY SOCIETY ABSTRACTS AUTHOR INDEX

531

1990 Teratology Society Abstracts Author Index Abbott, B.D., 193 Adam, G.A., P169 Adams", E.R., P42 Ager*, P.L., 89, 96 Agnew", D., P170 Alderman, B.W., P161 Ali", S.F., 220 Alles, A.J., 92 Ananthan-Nair", J., P60 Anderson*, C.A., 216, 217 Andrews", A,, P113 Andrews*, J.E., 33 Anson", J.F., P57 Antolick*, L.L., P123 Antonello*, J.M., 217 Astley", S.J., 207 Baden, J.M., P37, P140, P141, P142 Bailey*, J.R., 21, P61, P62 Baltimore-Washington Infant Study (BWIS) Group, 17, 198, P159 Barr, M., 176, P155, P156 Barrach, H.J., 209 Batastini", G., P135 Bechter, R., P107 Beck, S.L., P127 Beckman, D.A., 31 Behringer", R., P55 Beliles, R.P., 19, P66 Benkhaial", G., P73, P75 Bennett*, G., 214 Bennett, M.B., P114 Berdasco*, N.M., P54 Berman*, E., P117 Beyer, B., P47 Birnbaum, L.S., 193 Bisinger*, E.C., P167, P168 Blackburn", M.R., 178, 179 Blancato*, J.R., 23, 24 Blazak, W.F., P45, P46 Bohrman, J.S., P106 Bournias-Vardiabasis, N., P60 Bradford, J.C., P45 Branham, W.S., P113 Brent, R.L., 31, 202, P120, P121, P137 Brightwell, W.S., P124 Broening", 111, H.W., 220 Brown, G.L., P45, P46 Brown", K.S., 13 Brown, N.A., 25 Brown", N.T., 97 Bruni, J.E., P133 Bruyere, Jr., H.J., P71

*Denotes non-member.

Bucci, T.J., P48 Buehler, B., 90 Buehler, B.A., 30 Bura*, C., PllO Burroughs-Gleim*, C.J., 183, 204 Butler", B.L., P53 Buttar, H.S., P110, P145 Byrd, R.A., P41, P42, P43 Cacheiro", N.L.A., P129 Cameron*, A.M., P123 Campbell*, L.R., P130 Cefalo", R.C., 205 Chahoud, I., 12 Chambers", T.A., 200 Chen", J.J., 10 Chen*, S-F., 34 Chepelinsky", A.B., 191 Chernoff, N., 92, 188 Christian, M.S., P114 Christ", S.A., P68, P166 Chun, Y.H., P76 Church*, J.K., 179 Clark, R.L., 216, 217 Clarke*, D.O., 22 Clarren, S.K., 207 Cochran", J.D., 101 Coelho, C.N.D., 181 Collins*, M., 213, P61 Combs, R.D., P106 Comment", C., P118 Conner*, M., 215 Conover, D.L., P124 Cook", S.K., 7 Copeland*, M.F., P65 Cordero, J.F., 18, 82 Carey*, P., P170 Correa*, A,, 17 Creech Kraft, J., 21 Croen*, L.A., 15 Cuff*, J.M., 97 Cukierski, M.A., 189 Cummins*, S.K., P148 Cunningham", M., P129 Curran", E., 36 Curry4', C.J., 15, P150, P154, P160 Dacre, J.C., P48 Daston, G.P., 1184, P l l l Dauglitrey*, W., P47 Davis4:,D.G., P105 D'Angelo, M., 99, P56 Dean, J., P49 Dehaene*, Ph., 173 Delimont", D., 30, 90

Delp*, C., 90 Dennis, M.M., P45, P46 Denno", K.M., 182 Denny, K.H., P48 DeSesso, J.M., 210, P128, P138 Divine, B.L., P48 Diwan*, B.A., P143 Donovan", P.J., P143 Drake*, K.D., P169 Driscoll, C.D., P38 Droste", S., P152, P157 Duignan", J.M., 22 Duncan, P.A., 4 EckhofP, C., 86, P61, P62 Edmonds*, L.D., 16 Edwards*, M.J., 1, 175 Edwards, R.M., P124 Eisenmann", C.J., P146 Eisner*, S., 206 Elder*, J.A., P117 Ellison", A., 91 Elmer, W.A., 101 Elmore*, E., P l l l Elstein", K.H., 92 Englen*, M., 96 Epstein, D.L., P68 Eskesen*, M.B., P120, P121 Fadel", R.A., P134 Fahy*, M., 175 Fait", D.L., P52 Fantel, A.G., 183, 204, P152 Farmer, D.R., 36, 210 Farooqui", F., P55 Faustman, E.M., 103, 194 Feeley*, E.J.E., P73, P74, P75 Ferencz, C., 17, 198, P159 Fernandez*, M., P49 Field*, E.A., P51 Finnell, R.H., 30, 89, 96 Fischer*, B., 21 Fisher*, L.C., P52, P53 Fitzgerald*, M.P., P l l l Fitzsimmons, J., P152, P157 Francis, B.M., 92, 188 Fraser, F.C., 81 Freni", S.C., 9, 10 Froese", G., P133 Fu*, L-J., P115 Fujinaga, M., P37, P140, P141, P142 Furukawa", Y., P122 Gagna, C.E., P58, P144 Galaburda', A.M., P162 Garabadian", B., 81 Gasser, R., 85

532


Gaylor*, D.W., 8, 10 Gehris, A.L., 192, P56 Generoso", W.M., P129 George, J.D., P50 Gerhart, J.M., P167, P168 Germolec", D., P118 Giacobbe", R.L., P115, P116 Giacobbi", R.L., P109 Gilani, S.H., 206 Goeringer", G.C., 210, P128, P138 Goldberg", B., P120 Goodlett", C.R., 208 Gordon", D.A., P165 Grace", R., 195 Grafton*', T.F., 88 Graham, Jr., J.M., 1, 5, 175 Gray, J.A., P64, P65 Gray", Jr., L.E., 186 Greenberg, F., 5 Greene, R.M., 99, 100, 190, 192, P56 Gute", D.M., 199 Hales, B.F., 95 Hall, B.D., P147 Hall, J.G., 175 Hanley, T.R., Jr., P54 Hansen, D.K., 88, P57, P136, P139 Hanson, J.W., 18 Harris, J.A., 196, P148 Harris, M.J., 26, 28 Harvey", E.A., 13 Harvey", S., P170 Hassett-Sipple", B.M., 188 Hauck, R.-S., 87 HayesY,A.M., 13 Heger, W., 211 Heinrich-Hirsch", B., P70 Helmhout", S.L., P169 Hendrickx, A.G., 189, P72, P132 Henwood, S.M., P39 Heredia", D.J., 97 Hessel", E.M., P119 Higdon", G.L., P104 Hilbelink, D.R., 85 Hinson", W.G., P57 Hoang", K., 23, 24 Hoberman, A.M., 216, P114 Hofmann", D., P70 Holbrook, K.A., 79 Holmes, L.B., 13, P162 Holson", R.R., P136, P139 Honore, L.H., P150, P153, P154, P160 Hood, R.D., P105 Hunter*, E.S., 205 Infurna, R., P47 Jackson", E.C., P141 Jansen", E.H.J.M., P131 Jelovsek", F.R., P163 Jensen, M., P137 Jensh, R.P., P120, P121

Johnson", C.M., 215 Johnson, E.M., P77, P109, P115, P116 Johnson", K.A., 200, P54 Jollie, W.P., 32 Jones, K.L., 200 Jordan", W.H., P43 Juchau, M.R., P59 Juelch", S., P135 Juriloff, D.M., 26, 28 Kalousek, D.K., P149 Kalter, H., 29 Kapron-Bras, C.M., 95 Kapur", R.P., 172 Kavlock, R.J., P64, P65, P117 Keen, C.L., 184, 185, P151 Kelich", S.L., P127 Kelman, B.J., 20 Khasawinah, A.M., P44 Khera, K.S., 187 Khoshbin'*, S., 13 Khoury", M.J., 82 Kim'k, C.H., P76 Kimmel, C.A., 97 Kimmel, G.L., 97 Kirk", H.D., P54 Klein, N.W., 181 Klug", S., 12, 211 Knudsen, T.B., 178, 179 Kochhar, D.M., P78 Kodell", R.L., 10 Koehlerj', G., P47 Koeter, H.B.W.M., 219 Kolberg"', K.A., P46 Kolesari, G.L., P69 Korte", R., 189 Koszalka, T.R., 31 Kotch", L.E., 93 Kreig, E., P106 Kuhlmann, R.S., P69 Kwasigroch, T.E., PI24 LaBorde, J.B., P57, P139 Lammer, E.J., 174 Lary, J.M., P124 Laskey", J., 186 Lau", C., P123 Lauder*, J.M., 180 Laughlin, N.K., 23, 24 Law*', C., 209 Lee", Q.P., P59 Lehman-McKeeman*', L.D., 184 Leonard", Y.M., 216 Levy, R.H., 89 Lewin", P.A., P120 Li", D.K., 201 Li", Y.L., 35 Liang", C., 203 Lin", C.C., P153, P154 Lindstrom, P., P118 Little, S.A., 91, 94 Lloyd, J.B., 31, P137 Loberg", B., 27

Loffredo", C., 17 Logsdon", T.R., 188 Lo&o*, P.E., P52 Louik", C . , 199 Luecke", R.H., 11 Luster", M., P118 Ly", T., P116 Lvnch". D.W.. P105 Lyn-Cook", B:D., P113 Lyng, R.D., P112 Lyttle*, C.R., P113 Macdonald", J.S., 189 Machin", G.A., P150, P153, P154 Mackler, B., 204 Macphail", R.C., P117 Makris, N.G., P66 Malcoe", L.H., P148 Markham, J.K., P41, P42, P43, P104 Marr, M.C., P40, P50, P51 Massaro, E.J., 92 Mattison, D.R., P163 Mazze, R.I., P37, P141, P142 McCandless", D.W., 212, P63 McCarthy", A,, 25 McFadden", D.E., P149 McKenzie", J.J., P168, P169 McKinley", E.R., P104 McMurray", W.J., 35 Mercieca, M.D., P167, P168, P169 Merker, H-J., 211 Merriman':, T.N., P167 Meznarich", H.K., 20 Miller, M.T., 6, 177, P158 Miller, R.K., 203, P146 Miller", T.A., P171 Mills, J.L., 80 Mirkes, P.E., 91, 94, 195 Mitchell, A.A., 199 Mitchell", O.G., P58, P144 Miyata, K., 34 Moase, C.E., 98 Moeschler'$, J.B., 1, 175 Moffatt", J.H., P110, P145 Monteith, D., P112 Morrissey, R., P118 Morrissey, R.E., P40, P50, R.E., P5 1 Murakami'$, Y., P122 Myatt", J.K., P142 Myers", C.B., P40, P51 Namovic", M., 212, P63 Narotsky", M.G., P117 Nau, H., 21, 86, 87, P61, P62 Neeper-Bradley", T.L., P52 Neill", C.A., P159 Nelson, B.K., 209 Nelson", D.M., 36, 210 Nemec, M.D., P44 Neubert, D., 12, 211, P70 Neutra, R.R., P151


Newman, L.M., P77, P109, P115, P116 Newport*, G.D., 220 Ninomiya", M., 34 Nolen, G., P68 Oakley, G.P., 16 O'Flaherty*, E., 19 Ohriner*, W.D., 83 Oku*, S., 34 OLeary", E., 81 Oler", J., P120 Ono", S., 34 Osimitz", T.G., P39 Ostby", J., 186 Otey*, S.K., 178 Overmann*, G.J., 184 Paradice", B., P149 Parker, R.M., P48 Patterson, W.D., 82 Paulson", J., P49 Paulson, R., P49, P116 Pearce", B.A., 11 Penner*, J.D., P78 Persaud, T.V.N., P133, P134 Person", R.E., 183, 204 Peters, P.W.J., P108, P119, P131 Peterson, P.E., P72 Pexieder, T., P67, P125 Pfizenmaier Rousseil", M., P125 Phelan, M.C., 84 Piersma, A.H., P108, P119, P131 Pipkid', J.L., P57 Pisano, M.M., 190, 191 Pollard*, S., 101 Potter*, S., 27 Prados Frutos*, J.C., P125 Prahalada, S., 216 Price, C.J., P40, P50, P51 Price", S.R., P136 Raab*, D., P135 Randall, J.L., P68, P164 Read", *, E.J., P68, P164, P166 Rehm", S., P143 Rehnberg", B.F., P65 Rice, J.M., P143 Rickard*, L.B., P38 Roberts, L.G., 21 Roberts, R.M., 197 Robertson, R.T., 189 Robinson", J.E., P108 Robinson, K., P42 Rodier, P.M., 218 Rodwell, D.E., P167, P168 Rogers*, E.H., P65 Rogers, J.M., 33, 92, 184, 188 Rosa", F.W., 14 Rosen*, M.B., 92 Rosenbaum, K.N., 83 Roth", A.C., P165 Rowland*, J.R., P72

Rutledge, J.C., P129 Saal, H.M., 83 Sadler, T.W., 180, 182, 205 Sanyal*, M.K., 35 Scalf, R., P112 Schlicht", M., P117 Schoenfeld", D.A., 13 Schreiner*, C.M., 19, 212, 213, P63, P171 Schuler", R.L., P105 Schulman", J., 196, P148 Schwetz, B.A., P40, P50, P51 Scott, W.J., 19, 27, 212, 213, 214, P61, P63, P66, P171 Seeley", M.R., 103 Shah, R.M., P73, P74, P75 Shanfeld", J . , P49 Shapiro, L.R., 4 Sharma", A,, 203 Shaw, C-M., 172 Shaw", G.M., 15, P148 Shaw, P.B., P124 Shealy", Y.F., P78 Sheehan, D.M., 8, P57, P113, P136, P139 Shepard, T., P129, P152, P157 Shepard, T.H., 79, 172 Sherer", D., 203 Sherman", G.F., P162 Shields", H.E., P69 Shiota, K., 79 Shuey", D.L., 180 Sieberg, J.R., 174, 207 Sigmon", E.R., 186 Sikov, M.R., 20 Singh", I.J., 206 Skalko, R.G., 178, 179 Slikker, Jr., W., 21, 220, P61, P62 Smith, M.K., P68, P164, P165, P166 Sohal", G.S., P130 Sonawanne, B.R., 23,24 Stack, C.R., P52, P53 Stahlmann, R., 12 Stanton*, M.E., P123 Stedman:!:, D.B., P126 Stevens, J.L., 216 Stevenson", R.E., 84 Steward*, R.L., 89, 96 Stober", J.A., P68, P164, P166 Streissguth, A.P., 173 St-Vil", J., PllO Suchy", S.F., 84 Sulik, K.K., 92, 93, 205 Sullivan-Jones", P., P136 Superneau, D.W., 2 , 3 Supp", D., 27 Suto", A,, P142 Swan", S.H., P148, P151

533

Sweeney*, C., 194 Takahashi", E., P161 Tarantal, A.F., P132 Tasker, E.J., P44 Taubeneck", M.W., 184 Terlouw, G.D.C., P107 Tick, D.B., 5 Till", M.K., P120, P121 Tom", C., 26 Toraason, M., P106 Torfs", C.P., P160 Traina", V.M., P135 Trasler, D.G., 98 Tuan", R.S., 102 Twitty", L., P47 Tyl, R.W., P52, P53 Underhill", C.B., 210 Urbano, C.M., P127 Uriu-Hare", J.Y., 185, P151 Van Aerts, L.A.G.J.M., P108 Van Den Ham", W.A., P131 Van Miller*, J.P., P53 van Waes*, M., 30 VerhoeP, A., P108, P119, P131 Vetter*, C.M., 217 Veuthey", S., P67 Voellmy", R., P60 Vollmuth", T.A., P114 Vrbanic", M.A., P52, P53 Walsh", M., P170 Walter", R.M., 185 Webster, W.S., 93 Wegner", Chr., 27 Welsch, F., 22, P126 Werren, D., P124 Wertelecki, W., 2, 3 West, J.R., 208 Weston", W.M., 100 Whittaker", S.G., 103 Wickramaratne, G.A. de S., 7 Wier, P.J., 215 Wiley, M., P170 Willington, S.E., P106 Wilson, D.B., P72 Wilson", P.D., 17 Wilson", W.L., P145 Winters", R.S., 178 Wise, L.D., 189, 217 Wittfoht", W., 21, P61 Wolpert*, L., 25 Wong", M., 102 Woods", J.R., 203 Wosilait", W.D., 11 Yau*, E.T., P135 Young", A.V., P73 Young, J.F., 11, P57, P163 Zajak, W., P106 Zakeri, Z.F., P55 Zucker", R.M., 92

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