Ann Thorac Cardiovasc Surg 2015; 21: 183–187
Case Report
Online March 31, 2015 doi: 10.5761/atcs.cr.14-00207
Synchronous Primary Lung Cancer Presenting with Small Cell Carcinoma and Adenocarcinoma Yoko Yamamoto, MD,1 Ken Kodama, MD,1 Hiroyuki Yamato, MD,1 Masashi Takeda, MD, PhD,2 Hiroyuki Takamori, MD,3 and Takahiro Karasuno, MD, PhD3
Multiple synchronous primary lung cancers presenting with different histologic types are uncommon. Among reported cases with different histologic findings, only a few had small cell lung cancer (SCLC) and adenocarcinoma. This unusual combination of lung cancers has not been well reported. In this report, we describe two cases of synchronous primary lung cancer presenting with lymph node metastasis of SCLC and early-stage adenocarcinoma. Epidermal growth factor receptor (EGFR) mutation was not detected in either SCLC or adenocarcinoma in the two cases. Keywords: synchronous primary lung cancer, small cell carcinoma, adenocarcinoma
Introduction Multiple primary lung cancers arising synchronously or metachronously are uncommon. Among possible combinations, squamous cell carcinoma is by far the most common. Recently, frequency of diagnosing adenocarcinomas is increasing with the widespread use of computed tomography (CT). However, combinations with small cell lung cancer (SCLC) and adenocarcinoma are very rare. Through our literature search, we identified five cases of synchronous primary lung cancer (SPLC) presenting with SCLC and adenocarcinoma. Here, we describe two cases of SPLC presenting with SCLC and
Department of Thoracic Surgery, Yao Municipal Hospital, Yao, Osaka, Japan 2Department of Pathology, Yao Municipal Hospital, Yao, Osaka, Japan 3Department of Oncology, Yao Municipal Hospital, Yao, Osaka, Japan 1
Received: July 22, 2014; Accepted: August 12, 2014 Corresponding author: Yoko Yamamoto, MD. Department of Thoracic Surgery, Yao Municipal Hospital, 1-3-1 Ryuge-cho, Yao, Osaka 581-0069, Japan Email: [email protected] ©2015 The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery. All rights reserved.
Ann Thorac Cardiovasc Surg Vol. 21, No. 2 (2015)
adenocarcinoma. We also report the clinical characteristics, thus adding these two cases to the five previously reported cases.
Case Report Case 1 A 70-year-old man was referred to our hospital for an abnormal shadow on chest CT. His past medical history was unremarkable but he had a smoking history (Brinkman index: 2040). Physical examination revealed no abnormalities. Serum levels of CYFRA and Pro-GRP were elevated to 3.5 ng/mL (normal range:
Case Report
Online March 31, 2015 doi: 10.5761/atcs.cr.14-00207
Synchronous Primary Lung Cancer Presenting with Small Cell Carcinoma and Adenocarcinoma Yoko Yamamoto, MD,1 Ken Kodama, MD,1 Hiroyuki Yamato, MD,1 Masashi Takeda, MD, PhD,2 Hiroyuki Takamori, MD,3 and Takahiro Karasuno, MD, PhD3
Multiple synchronous primary lung cancers presenting with different histologic types are uncommon. Among reported cases with different histologic findings, only a few had small cell lung cancer (SCLC) and adenocarcinoma. This unusual combination of lung cancers has not been well reported. In this report, we describe two cases of synchronous primary lung cancer presenting with lymph node metastasis of SCLC and early-stage adenocarcinoma. Epidermal growth factor receptor (EGFR) mutation was not detected in either SCLC or adenocarcinoma in the two cases. Keywords: synchronous primary lung cancer, small cell carcinoma, adenocarcinoma
Introduction Multiple primary lung cancers arising synchronously or metachronously are uncommon. Among possible combinations, squamous cell carcinoma is by far the most common. Recently, frequency of diagnosing adenocarcinomas is increasing with the widespread use of computed tomography (CT). However, combinations with small cell lung cancer (SCLC) and adenocarcinoma are very rare. Through our literature search, we identified five cases of synchronous primary lung cancer (SPLC) presenting with SCLC and adenocarcinoma. Here, we describe two cases of SPLC presenting with SCLC and
Department of Thoracic Surgery, Yao Municipal Hospital, Yao, Osaka, Japan 2Department of Pathology, Yao Municipal Hospital, Yao, Osaka, Japan 3Department of Oncology, Yao Municipal Hospital, Yao, Osaka, Japan 1
Received: July 22, 2014; Accepted: August 12, 2014 Corresponding author: Yoko Yamamoto, MD. Department of Thoracic Surgery, Yao Municipal Hospital, 1-3-1 Ryuge-cho, Yao, Osaka 581-0069, Japan Email: [email protected] ©2015 The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery. All rights reserved.
Ann Thorac Cardiovasc Surg Vol. 21, No. 2 (2015)
adenocarcinoma. We also report the clinical characteristics, thus adding these two cases to the five previously reported cases.
Case Report Case 1 A 70-year-old man was referred to our hospital for an abnormal shadow on chest CT. His past medical history was unremarkable but he had a smoking history (Brinkman index: 2040). Physical examination revealed no abnormalities. Serum levels of CYFRA and Pro-GRP were elevated to 3.5 ng/mL (normal range:
