iii303

Nephrology Dialysis Transplantation Plus 2010 3(Supplement 3): iii275–iii547

Poster Session 2 Acid-base and ion transport Su001

Su002

SPAK KNOCKOUT MICE EXPRESS GITELMAN’S SYNDROME AND IMPAIRED VASOCONSTRICTION

Sung-Sen Yang 1 , Chin-Chen Wu 2 , Shu-Wha Lin 3 , Shinichi Uchida 4 , Sei Sasaki 4 , Shih-Hua Lin 1 . 1 Division of Nephrology, Department of Medicine, Tri-Service General Hospital, Taipei, Taiwan; 2 Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan; 3 Graduate Institute of Medical Technology, National Taiwan University, Taipei, Taiwan; 4 Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan

Blood Pressure (BP), blood and urine biochemistries in SPAK-null mice SPAK genotype (n) BP (mmHg) Systolic Diastolic Mean Weight (gram) Plasma Aldosterone (pg/ml) Na+ (mmol/l) K+ (mmol/l) Cl- (mmol/l) Total Ca2+ (mg/dl) Mg2+ (mg/dl) Cr (mg/dl) Urine (ml/day) Na+ (μmol/day) K+ (μmol/day) Cl- (μmol/day) FENa (%) FEK (%) FEMg (%) Ca2+/Cr (mg/mg)

+/+ (10)

+/– (16)

–/– (10)

109.5±4.5 76.2±5.6 87.2±5.6 23.8±2.5

95.6±3.6* 62.1±4.6* 74.0±4.5* 23.6±3.3

93.2±4.1** 59.3±6.2** 71.2±3.5** 23.6±3.3

570±158 156±3 4.2±0.3 114±2 9.6±0.2 2.5±0.1 0.16±0.05 1.5±0.4 97±21 125±8 85±10 0.21±0.07 15.4±3.7 4.8±0.9 0.19±0.03

707±226 158±3 4.0±0.3 113±3 9.5±0.4 2.3±0.2 0.17±0.04 1.5±0.7 85±25 124±25 92±11 0.23±0.08 17.6±6.8 5.2±0.8 0.17±0.05

1006±394** 157±3 3.6±0.2** 109±2** 9.7±0.3 1.9±0.2** 0.16±0.04 1.6±0.4 89±16 142±22 89±15 0.22±0.09 22.6±4.2** 6.1±0.7** 0.12±0.02**

Cr: creatinine; FENa, FEK and FEMg represent the fractional excretion of Na+, K+ and Mg2+, respectively. **denotes p

Sunday, june 27, 2010: poster session 2.

Sunday, june 27, 2010: poster session 2. - PDF Download Free
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