Carcinogenesis vol.13 no.8 pp.1403-1408, 1992
Strategies for advancement of short-term mutagenicity tests: on the optimal ionic strength for the liver microsomal assay
M.Paolini1, R.Meslrca1, L.Pozzetti1, P.Silingardi2, S.Grilli2 and G.Cantelli-Forti1'3 'Dipartiinento di Fannacologica, Laboraton di Biochimica Tossicologica, Istituto di Canccrologia, Universita degli Studi di Bologna, Italy and ^Division of Environmental Toxicology and Community Health, University of Texas Medical Branch, Galveston, TX, USA
increased A^ phase-I/Agp phase-II ratio), as well as DNA binding and genotoxic response.
2
'Abbreviations: LMA, liver microsomal assay; T, ionic strength; A^, mean specific activity; TBSO, thiobenzamide 5-oxidase; GST, glutathione S-transferase; EH, epoxide hydrolase; UDP-GT, UDP-glucuronosyl transferase; LP, lipid peroxidation; DMNA, dimethylnitrosamine; 0-NF, /3-naphthoflavone; PB, sodium phenobarbital, IS, isosafrol; DNCB, l
Strategies for advancement of short-term mutagenicity tests: on the optimal ionic strength for the liver microsomal assay
M.Paolini1, R.Meslrca1, L.Pozzetti1, P.Silingardi2, S.Grilli2 and G.Cantelli-Forti1'3 'Dipartiinento di Fannacologica, Laboraton di Biochimica Tossicologica, Istituto di Canccrologia, Universita degli Studi di Bologna, Italy and ^Division of Environmental Toxicology and Community Health, University of Texas Medical Branch, Galveston, TX, USA
increased A^ phase-I/Agp phase-II ratio), as well as DNA binding and genotoxic response.
2
'Abbreviations: LMA, liver microsomal assay; T, ionic strength; A^, mean specific activity; TBSO, thiobenzamide 5-oxidase; GST, glutathione S-transferase; EH, epoxide hydrolase; UDP-GT, UDP-glucuronosyl transferase; LP, lipid peroxidation; DMNA, dimethylnitrosamine; 0-NF, /3-naphthoflavone; PB, sodium phenobarbital, IS, isosafrol; DNCB, l
