Scandinavian Journal of Gastroenterology
ISSN: 0036-5521 (Print) 1502-7708 (Online) Journal homepage: http://www.tandfonline.com/loi/igas20
Steady-State Pharmacokinetics of a New 4-Gram 5-Aminosalicylic Acid Retention Enema in Patients with Ulcerative Colitis in Remission S. Almer, B. Norlander, M. Ström & H. Osterwald To cite this article: S. Almer, B. Norlander, M. Ström & H. Osterwald (1991) Steady-State Pharmacokinetics of a New 4-Gram 5-Aminosalicylic Acid Retention Enema in Patients with Ulcerative Colitis in Remission, Scandinavian Journal of Gastroenterology, 26:3, 327-335 To link to this article: http://dx.doi.org/10.3109/00365529109025050
Published online: 08 Jul 2009.
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Date: 11 January 2016, At: 00:26
Steady-State Pharmacokinetics of a New 4-Gram 5-Aminosalicylic Acid Retention Enema in Patients with Ulcerative Colitis in Remission
Downloaded by [La Trobe University] at 00:26 11 January 2016
S. ALMER, B. NORLANDER, M. STROM & H. OSTERWALD Depts. of Internal Medicine and Clinical Pharmacology, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden, and Dept . of Pharmaceutical Development, Smith Kline Dauelsberg, Gottingen, Germany Almer S, Norlander B, Strom M, Osterwald H. Steady-state pharmacokinetics of a new 4-gram 5-aminosalicylicacid retention enema in patients with ulcerative colitis in remission. Scand J Gastroenterol 1991, 26, 327-335 The pharmacokinetic profile of a new 4-g 5-aminosalicylic acid (5-ASA) retention enema, Mesasal*, was investigated. Nine patients with ulcerative colitis in remission and one patient with mild disease activity received one enema for seven consecutive nights. They were admitted to hospital for administration of the eighth enema. Plasma concentration and urinary excretion of 5-ASA and acetyl-5-aminosalicylicacid (Ac5-ASA) were studied for 45 h and faecal excretion for 24 h after administration of the last enema. The median peak plasma concentration of 5-ASA was 0.92 (range, 0.59-1.87) pg/ml at a median of 11 h after administration, and of Ac-5-ASA 1.62 (range, 1.03-4.36) pg/ml at a median of 12 h after administration. On average, the plasma concentration of Ac-5-ASA was almost twice that of 5-ASA at each sampling period. At 24 h after administration the median plasma concentration for 5-ASA was 0.12 (range, 04.77) pg/ml and for At-5-ASA 0.36 (range, 0.01-1.6) pg/ml. At 45 h after administration low levels of both 5-ASA (
ISSN: 0036-5521 (Print) 1502-7708 (Online) Journal homepage: http://www.tandfonline.com/loi/igas20
Steady-State Pharmacokinetics of a New 4-Gram 5-Aminosalicylic Acid Retention Enema in Patients with Ulcerative Colitis in Remission S. Almer, B. Norlander, M. Ström & H. Osterwald To cite this article: S. Almer, B. Norlander, M. Ström & H. Osterwald (1991) Steady-State Pharmacokinetics of a New 4-Gram 5-Aminosalicylic Acid Retention Enema in Patients with Ulcerative Colitis in Remission, Scandinavian Journal of Gastroenterology, 26:3, 327-335 To link to this article: http://dx.doi.org/10.3109/00365529109025050
Published online: 08 Jul 2009.
Submit your article to this journal
Article views: 8
View related articles
Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=igas20 Download by: [La Trobe University]
Date: 11 January 2016, At: 00:26
Steady-State Pharmacokinetics of a New 4-Gram 5-Aminosalicylic Acid Retention Enema in Patients with Ulcerative Colitis in Remission
Downloaded by [La Trobe University] at 00:26 11 January 2016
S. ALMER, B. NORLANDER, M. STROM & H. OSTERWALD Depts. of Internal Medicine and Clinical Pharmacology, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden, and Dept . of Pharmaceutical Development, Smith Kline Dauelsberg, Gottingen, Germany Almer S, Norlander B, Strom M, Osterwald H. Steady-state pharmacokinetics of a new 4-gram 5-aminosalicylicacid retention enema in patients with ulcerative colitis in remission. Scand J Gastroenterol 1991, 26, 327-335 The pharmacokinetic profile of a new 4-g 5-aminosalicylic acid (5-ASA) retention enema, Mesasal*, was investigated. Nine patients with ulcerative colitis in remission and one patient with mild disease activity received one enema for seven consecutive nights. They were admitted to hospital for administration of the eighth enema. Plasma concentration and urinary excretion of 5-ASA and acetyl-5-aminosalicylicacid (Ac5-ASA) were studied for 45 h and faecal excretion for 24 h after administration of the last enema. The median peak plasma concentration of 5-ASA was 0.92 (range, 0.59-1.87) pg/ml at a median of 11 h after administration, and of Ac-5-ASA 1.62 (range, 1.03-4.36) pg/ml at a median of 12 h after administration. On average, the plasma concentration of Ac-5-ASA was almost twice that of 5-ASA at each sampling period. At 24 h after administration the median plasma concentration for 5-ASA was 0.12 (range, 04.77) pg/ml and for At-5-ASA 0.36 (range, 0.01-1.6) pg/ml. At 45 h after administration low levels of both 5-ASA (
