Accepted Manuscript Relation of Smoking Status to Outcomes After Cardiopulmonary Resuscitation for InHospital Cardiac Arrest Tanush Gupta, MD Dhaval Kolte, MD, PhD Sahil Khera, MD Wilbert S. Aronow, MD Chandrasekar Palaniswamy, MD Marjan Mujib, MD Diwakar Jain, MD Sachin Sule, MD Ali Ahmed, MD Sei Iwai, MD Paul Eugenio, MD Seth Lessner, MD William H. Frishman, MD Julio A. Panza, MD Gregg C. Fonarow, MD PII:

S0002-9149(14)01035-2

DOI:

10.1016/j.amjcard.2014.04.021

Reference:

AJC 20425

To appear in:

The American Journal of Cardiology

Received Date: 7 March 2014 Revised Date:

14 April 2014

Accepted Date: 15 April 2014

Please cite this article as: Gupta T, Kolte D, Khera S, Aronow WS, Palaniswamy C, Mujib M, Jain D, Sule S, Ahmed A, Iwai S, Eugenio P, Lessner S, Frishman WH, Panza JA, Fonarow GC, Relation of Smoking Status to Outcomes After Cardiopulmonary Resuscitation for In-Hospital Cardiac Arrest, The American Journal of Cardiology (2014), doi: 10.1016/j.amjcard.2014.04.021. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

ACCEPTED MANUSCRIPT Relation of Smoking Status to Outcomes After Cardiopulmonary Resuscitation for InHospital Cardiac Arrest Tanush Gupta, MDa*; Dhaval Kolte, MD, PhDa*; Sahil Khera, MDa; Wilbert S. Aronow, MDb; Chandrasekar Palaniswamy, MDb; Marjan Mujib, MDa; Diwakar Jain, MDb; Sachin

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Sule, MDa; Ali Ahmed, MDc; Sei Iwai, MDb; Paul Eugenio, MDb; Seth Lessner, MDb; William H. Frishman, MDb; Julio A. Panza, MDb; Gregg C. Fonarow, MDd

Department of Medicine, bDivision of Cardiology, New York Medical College, Valhalla, NY

c

University of Alabama at Birmingham, Birmingham, AL

David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA

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d

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a

Conflicts of Interest: None Source of Funding: None

Gregg C. Fonarow, MD

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Corresponding author:

Department of Medicine, Division of Cardiology,

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University of California at Los Angeles 10833 Le Conte Avenue,

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Los Angeles, CA 90095-1679

Phone: (310) 206-9112; Fax: (310) 206-9111 E-mail: [email protected]

Running title: Smoking and Outcomes After IHCA *Tanush Gupta, MD and Dhaval Kolte, MD, PhD have contributed equally to this study. This paper was presented at the American College of Cardiology 63rd Scientific Sessions in Washington DC on March 29, 2014. 1

ACCEPTED MANUSCRIPT Abstract In-hospital cardiac arrest (IHCA) is common and is associated with poor prognosis. Data on the effect of smoking on outcomes after IHCA are limited. We analyzed the Nationwide Inpatient Sample databases from 2003 to 2011 for all patients ≥18 years of age who

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underwent cardiopulmonary resuscitation (CPR) for IHCA to examine the differences in survival to hospital discharge and neurological status between smokers and non-smokers. Of the 838,464 patients with CPR for IHCA, 116,569 (13.9%) were smokers. Smokers were

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more likely to be younger, Caucasian and male. They had a higher prevalence of

dyslipidemia, coronary artery disease, hypertension, chronic pulmonary disease, obesity, and

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peripheral vascular disease. Atrial fibrillation, heart failure, and diabetes mellitus with complications were less prevalent in smokers. Smokers were more likely to have a primary diagnosis of acute myocardial infarction (14.8% versus 9.1%, P

Relation of smoking status to outcomes after cardiopulmonary resuscitation for in-hospital cardiac arrest.

In-hospital cardiac arrest (IHCA) is common and is associated with poor prognosis. Data on the effect of smoking on outcomes after IHCA are limited. W...
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