Accepted Manuscript Prevalence and Trends of Isolated Systolic Hypertension among Untreated Adults in the United States Xuefeng Liu, PhD, Carlos J. Rodriguez, MD, MPH, Kesheng Wang, PhD PII:
S1933-1711(15)00003-0
DOI:
10.1016/j.jash.2015.01.002
Reference:
JASH 629
To appear in:
Journal of the American Society of Hypertension
Received Date: 3 October 2014 Revised Date:
4 January 2015
Accepted Date: 5 January 2015
Please cite this article as: Liu X, Rodriguez CJ, Wang K, Prevalence and Trends of Isolated Systolic Hypertension among Untreated Adults in the United States, Journal of the American Society of Hypertension (2015), doi: 10.1016/j.jash.2015.01.002. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT
Prevalence and Trends of Isolated Systolic Hypertension among Untreated Adults in the United States Xuefeng Liu PhD1, Carlos J. Rodriguez, MD, MPH,2,3, Kesheng Wang PhD4 Department of Systems Leadership and Effectiveness Science at University of Michigan,
RI PT
1
Ann Arbor, MI 48109, USA. 2
Department of Epidemiology Division of Public Health Sciences, Wake Forest School of
3
Department of Internal Medicine (Cardiology), Wake Forest School of Medicine, Winston-
M AN U
Salem, NC 27157, USA. 4
SC
Medicine, Winston-Salem, NC 27157, USA.
Department of Biostatistics and Epidemiology at East Tennessee State University, Johnson
TE D
City, TN 37614, USA.
Correspondence to: Xuefeng Liu, PhD, Department of Systems Leadership and Effectiveness Science at University of Michigan, 400 N Ingalls St, Ann Arbor, MI 48109, Tel:
EP
(734) 647-4929, Fax: (734) 647-2416, Email: [email protected]
AC C
Running Head: Isolated Systolic Hypertension Funding: Research for this study was supported by an HRSA grant Conflict of Interest: None Word Count: 3,077
Number of Tables: 4 Number of Figures: 1
1
ACCEPTED MANUSCRIPT
Background: Isolated systolic hypertension (ISH) is an important hypertension subtype that predominates in the old people. However, the prevalence and long-term trends of ISH among untreated adults have not been reported.
RI PT
Design and Methods: A study sample of 24,653 participants aged ≥18 years were selected from the National Health and Nutrition Examination Survey 1999-2010 (12,018 persons from 19992004 and 12,635 persons from 2005-2010), representing a probability sample of the US civilian
SC
population. The prevalence and 95% confidence intervals (CIs) of untreated ISH were estimated to compare differences in the prevalence over two 6-year periods by conducting the independent
M AN U
survey t-test.
Results: The prevalence of untreated ISH was 9.4% in 1999-2010 and decreased from 10.3% in 1999-2004 to 8.5% in 2005-2010 (p=0.00248). Old persons, females, and non-Hispanic blacks had higher prevalence of untreated ISH. Compared with 1999-2004, the prevalence of untreated
TE D
ISH in 2005-2010 decreased among older (33.6%, 95% CI=30.9-36.3% vs. 25.1%, 95% CI=22.7-27.5%) and female individuals (8.3%, 95% CI=7.5-9.2% vs. 11.4%, 95% CI=10.412.3%). The stratified prevalence of untreated ISH declined in 2005-2010 (vs. 1999-2004) for
EP
older non-Hispanic whites (24.6% vs. 32.8%; p
S1933-1711(15)00003-0
DOI:
10.1016/j.jash.2015.01.002
Reference:
JASH 629
To appear in:
Journal of the American Society of Hypertension
Received Date: 3 October 2014 Revised Date:
4 January 2015
Accepted Date: 5 January 2015
Please cite this article as: Liu X, Rodriguez CJ, Wang K, Prevalence and Trends of Isolated Systolic Hypertension among Untreated Adults in the United States, Journal of the American Society of Hypertension (2015), doi: 10.1016/j.jash.2015.01.002. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT
Prevalence and Trends of Isolated Systolic Hypertension among Untreated Adults in the United States Xuefeng Liu PhD1, Carlos J. Rodriguez, MD, MPH,2,3, Kesheng Wang PhD4 Department of Systems Leadership and Effectiveness Science at University of Michigan,
RI PT
1
Ann Arbor, MI 48109, USA. 2
Department of Epidemiology Division of Public Health Sciences, Wake Forest School of
3
Department of Internal Medicine (Cardiology), Wake Forest School of Medicine, Winston-
M AN U
Salem, NC 27157, USA. 4
SC
Medicine, Winston-Salem, NC 27157, USA.
Department of Biostatistics and Epidemiology at East Tennessee State University, Johnson
TE D
City, TN 37614, USA.
Correspondence to: Xuefeng Liu, PhD, Department of Systems Leadership and Effectiveness Science at University of Michigan, 400 N Ingalls St, Ann Arbor, MI 48109, Tel:
EP
(734) 647-4929, Fax: (734) 647-2416, Email: [email protected]
AC C
Running Head: Isolated Systolic Hypertension Funding: Research for this study was supported by an HRSA grant Conflict of Interest: None Word Count: 3,077
Number of Tables: 4 Number of Figures: 1
1
ACCEPTED MANUSCRIPT
Background: Isolated systolic hypertension (ISH) is an important hypertension subtype that predominates in the old people. However, the prevalence and long-term trends of ISH among untreated adults have not been reported.
RI PT
Design and Methods: A study sample of 24,653 participants aged ≥18 years were selected from the National Health and Nutrition Examination Survey 1999-2010 (12,018 persons from 19992004 and 12,635 persons from 2005-2010), representing a probability sample of the US civilian
SC
population. The prevalence and 95% confidence intervals (CIs) of untreated ISH were estimated to compare differences in the prevalence over two 6-year periods by conducting the independent
M AN U
survey t-test.
Results: The prevalence of untreated ISH was 9.4% in 1999-2010 and decreased from 10.3% in 1999-2004 to 8.5% in 2005-2010 (p=0.00248). Old persons, females, and non-Hispanic blacks had higher prevalence of untreated ISH. Compared with 1999-2004, the prevalence of untreated
TE D
ISH in 2005-2010 decreased among older (33.6%, 95% CI=30.9-36.3% vs. 25.1%, 95% CI=22.7-27.5%) and female individuals (8.3%, 95% CI=7.5-9.2% vs. 11.4%, 95% CI=10.412.3%). The stratified prevalence of untreated ISH declined in 2005-2010 (vs. 1999-2004) for
EP
older non-Hispanic whites (24.6% vs. 32.8%; p
