Am J Cancer Res 2015;5(5):1751-1761 www.ajcr.us /ISSN:2156-6976/ajcr0006864
Original Article Inhibition of STAT3 reduces proliferation and invasion in salivary gland adenoid cystic carcinoma Lin-Lin Bu1,2, Wei-Wei Deng1,2, Cong-Fa Huang1, Bing Liu2, Wen-Feng Zhang2, Zhi-Jun Sun1,2 The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China; 2Department of Oral and Maxillofacial-Head and Neck Oncology, School and Hospital of Stomatology, Wuhan University, Wuhan, 430079, China 1
Received February 8, 2015; Accepted April 12, 2015; Epub April 15, 2015; Published May 1, 2015 Abstract: In this study, we accessed the expression and correlation of p-STAT3 with Survivin, Cyclin D1, CD147, Slug and Ki67 by immunohistochemical staining of human tissue microarray which contains 72 adenoid cystic carcinoma (AdCC), 12 pleomorphic adenoma (PMA) and 18 normal salivary gland (NSG) using digital pathological scanner and scoring system. We found that the expression of p-STAT3, Survivin, Slug, Cyclin D1 and CD147 was significantly increased in AdCC as compared with PMA and (or) NSG (p0.05). Correlation analysis of these proteins revealed that p-STAT3 up-regulates the expression of Survivin, Slug, Cyclin D1 and CD147 (p
Original Article Inhibition of STAT3 reduces proliferation and invasion in salivary gland adenoid cystic carcinoma Lin-Lin Bu1,2, Wei-Wei Deng1,2, Cong-Fa Huang1, Bing Liu2, Wen-Feng Zhang2, Zhi-Jun Sun1,2 The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China; 2Department of Oral and Maxillofacial-Head and Neck Oncology, School and Hospital of Stomatology, Wuhan University, Wuhan, 430079, China 1
Received February 8, 2015; Accepted April 12, 2015; Epub April 15, 2015; Published May 1, 2015 Abstract: In this study, we accessed the expression and correlation of p-STAT3 with Survivin, Cyclin D1, CD147, Slug and Ki67 by immunohistochemical staining of human tissue microarray which contains 72 adenoid cystic carcinoma (AdCC), 12 pleomorphic adenoma (PMA) and 18 normal salivary gland (NSG) using digital pathological scanner and scoring system. We found that the expression of p-STAT3, Survivin, Slug, Cyclin D1 and CD147 was significantly increased in AdCC as compared with PMA and (or) NSG (p0.05). Correlation analysis of these proteins revealed that p-STAT3 up-regulates the expression of Survivin, Slug, Cyclin D1 and CD147 (p
