Expert Review of Vaccines
ISSN: 1476-0584 (Print) 1744-8395 (Online) Journal homepage: http://www.tandfonline.com/loi/ierv20
Influenza vaccination in pediatric age Susanna Esposito & Nicola Principi To cite this article: Susanna Esposito & Nicola Principi (2015) Influenza vaccination in pediatric age, Expert Review of Vaccines, 14:6, 785-787 To link to this article: http://dx.doi.org/10.1586/14760584.2015.1037290
Published online: 15 Apr 2015.
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Date: 05 November 2015, At: 20:07
Editorial
Influenza vaccination in pediatric age Expert Rev. Vaccines 14(6), 785–787 (2015)
Downloaded by [218.26.109.114] at 20:07 05 November 2015
Susanna Esposito Author for correspondence: Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Universita` degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy Tel.: +39 025 503 2498 Fax: +39 025 032 0206 [email protected]
Nicola Principi Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Universita` degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
To increase the protective efficacy against influenza in pediatric populations, several attempts to modify the composition or the route of administration of an inactivated influenza vaccine have been made. Adjuvants have been added, vaccines with higher antigen content have been developed and intradermal administration of inactivated influenza vaccine with a variety of devices has been considered. Such attempts to develop universal influenza vaccines will continue to be made. For some time, the knowledge that the licensed influenza vaccines induce strain-specific immunity and may have low efficacy in unexpected outbreaks of new epidemic strains has motivated the development of preparations with broader and longer-lasting protection. Ideally, children would be included early in the evaluation of the efficacy of new vaccines to avoid lengthy delays in making the protection available to this vulnerable population. Moreover, further studies to clarify definitively whether protection of infants
ISSN: 1476-0584 (Print) 1744-8395 (Online) Journal homepage: http://www.tandfonline.com/loi/ierv20
Influenza vaccination in pediatric age Susanna Esposito & Nicola Principi To cite this article: Susanna Esposito & Nicola Principi (2015) Influenza vaccination in pediatric age, Expert Review of Vaccines, 14:6, 785-787 To link to this article: http://dx.doi.org/10.1586/14760584.2015.1037290
Published online: 15 Apr 2015.
Submit your article to this journal
Article views: 71
View related articles
View Crossmark data
Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=ierv20 Download by: [218.26.109.114]
Date: 05 November 2015, At: 20:07
Editorial
Influenza vaccination in pediatric age Expert Rev. Vaccines 14(6), 785–787 (2015)
Downloaded by [218.26.109.114] at 20:07 05 November 2015
Susanna Esposito Author for correspondence: Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Universita` degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy Tel.: +39 025 503 2498 Fax: +39 025 032 0206 [email protected]
Nicola Principi Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Universita` degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
To increase the protective efficacy against influenza in pediatric populations, several attempts to modify the composition or the route of administration of an inactivated influenza vaccine have been made. Adjuvants have been added, vaccines with higher antigen content have been developed and intradermal administration of inactivated influenza vaccine with a variety of devices has been considered. Such attempts to develop universal influenza vaccines will continue to be made. For some time, the knowledge that the licensed influenza vaccines induce strain-specific immunity and may have low efficacy in unexpected outbreaks of new epidemic strains has motivated the development of preparations with broader and longer-lasting protection. Ideally, children would be included early in the evaluation of the efficacy of new vaccines to avoid lengthy delays in making the protection available to this vulnerable population. Moreover, further studies to clarify definitively whether protection of infants
