RESEARCH ARTICLE
Individual and Population Level Impact of Key HIV Risk Factors on HIV Incidence Rates in Durban, South Africa Gita Ramjee1,2,3*, Suri Moonsamy1, Nathlee Samantha Abbai1, Handan Wand4 1 HIV Prevention Research Unit, Medical Research Council, Durban, South Africa, 2 Department of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, United Kingdom, 3 Department of Global Health, School of Medicine, University of Washington, Washington DC, United States of America, 4 National Center for HIV Epidemiology and Clinical Research, Sydney, Australia * [email protected]
a11111
Abstract
OPEN ACCESS Citation: Ramjee G, Moonsamy S, Abbai NS, Wand H (2016) Individual and Population Level Impact of Key HIV Risk Factors on HIV Incidence Rates in Durban, South Africa. PLoS ONE 11(4): e0153969. doi:10.1371/journal.pone.0153969 Editor: Weijing He, University of Texas Health Science Center San Antonio Texas, UNITED STATES Received: October 8, 2015
We aimed to estimate the individual and joint impact of age, marital status and diagnosis with sexually transmitted infections (STIs) on HIV acquisition among young women at a population level in Durban, KwaZulu-Natal, South Africa. A total of 3,978 HIV seronegative women were recruited for four biomedical intervention trials from 2002–2009. Point and interval estimates of partial population attributable risk (PAR) were used to quantify the proportion of HIV seroconversions which can be prevented if a combination of risk factors is eliminated from a target population. More than 70% of the observed HIV acquisitions were collectively attributed to the three risk factors: younger age (
Individual and Population Level Impact of Key HIV Risk Factors on HIV Incidence Rates in Durban, South Africa Gita Ramjee1,2,3*, Suri Moonsamy1, Nathlee Samantha Abbai1, Handan Wand4 1 HIV Prevention Research Unit, Medical Research Council, Durban, South Africa, 2 Department of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, United Kingdom, 3 Department of Global Health, School of Medicine, University of Washington, Washington DC, United States of America, 4 National Center for HIV Epidemiology and Clinical Research, Sydney, Australia * [email protected]
a11111
Abstract
OPEN ACCESS Citation: Ramjee G, Moonsamy S, Abbai NS, Wand H (2016) Individual and Population Level Impact of Key HIV Risk Factors on HIV Incidence Rates in Durban, South Africa. PLoS ONE 11(4): e0153969. doi:10.1371/journal.pone.0153969 Editor: Weijing He, University of Texas Health Science Center San Antonio Texas, UNITED STATES Received: October 8, 2015
We aimed to estimate the individual and joint impact of age, marital status and diagnosis with sexually transmitted infections (STIs) on HIV acquisition among young women at a population level in Durban, KwaZulu-Natal, South Africa. A total of 3,978 HIV seronegative women were recruited for four biomedical intervention trials from 2002–2009. Point and interval estimates of partial population attributable risk (PAR) were used to quantify the proportion of HIV seroconversions which can be prevented if a combination of risk factors is eliminated from a target population. More than 70% of the observed HIV acquisitions were collectively attributed to the three risk factors: younger age (
