Original Research Article
Hepatoprotective activity of Mammea africana ethanol stem bark extract Jude Efiom Okokon*, Michael Burata Bawo1, Herbert Orji Mbagwu Department of Pharmacology and Toxicology Faculty of Pharmacy, University of Uyo, Uyo, Nigeria Article history: Received: Dec 19, 2014 Received in revised form: Jun 14, 2015 Accepted: Jul 13, 2015 Vol. 6, No. 2, Mar-Apr 2016, 248-259. * Corresponding Author: Tel: +234-8023453678 Fax: +234-85-202694 [email protected] Keywords: Medicinal plant Mammea africana Hepatoprotective Antioxidant
Abstract Objective: The stem bark of Mammea africana Sabine (Guttiferae), (M. africana) a common plant that has been traditionally used to treat various diseases and ailments was evaluated for hepatoprotective potentials against paracetamolinduced liver injury in rats. Materials and Methods: The hepatoprotective effect of the stem bark extract (30-90 mg/kg) was evaluated by the assay of liver function parameters, namely total and direct bilirubin, serum protein and albumin, total cholesterol, alanine aminotransaminase (ALT), aspartate aminotransaminase (AST), and alkaline phosphatase activities (ALP), antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) and histopathological study of the liver. Results: Administration of the stem bark extract caused a significant (p
Hepatoprotective activity of Mammea africana ethanol stem bark extract Jude Efiom Okokon*, Michael Burata Bawo1, Herbert Orji Mbagwu Department of Pharmacology and Toxicology Faculty of Pharmacy, University of Uyo, Uyo, Nigeria Article history: Received: Dec 19, 2014 Received in revised form: Jun 14, 2015 Accepted: Jul 13, 2015 Vol. 6, No. 2, Mar-Apr 2016, 248-259. * Corresponding Author: Tel: +234-8023453678 Fax: +234-85-202694 [email protected] Keywords: Medicinal plant Mammea africana Hepatoprotective Antioxidant
Abstract Objective: The stem bark of Mammea africana Sabine (Guttiferae), (M. africana) a common plant that has been traditionally used to treat various diseases and ailments was evaluated for hepatoprotective potentials against paracetamolinduced liver injury in rats. Materials and Methods: The hepatoprotective effect of the stem bark extract (30-90 mg/kg) was evaluated by the assay of liver function parameters, namely total and direct bilirubin, serum protein and albumin, total cholesterol, alanine aminotransaminase (ALT), aspartate aminotransaminase (AST), and alkaline phosphatase activities (ALP), antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) and histopathological study of the liver. Results: Administration of the stem bark extract caused a significant (p
