Foreword Special Focus Issue: Forensic and clinical toxicology
For reprint orders, please contact [email protected]
Forensic and clinical toxicology “This 2014 special issue of Bioanalysis is a collection of articles highlighting
emerging bioanalytical fields focusing on forensic and clinical toxicology. Internationally recognized and respected experts have contributed to this issue, and articles cover topics such as the current role of online extraction approaches in clinical and forensic toxicology.
”
Keywords: clinical toxicology • forensic toxicology • mass spectrometry
This 2014 special issue of Bioanalysis is a collection of articles highlighting emerging bioanalytical fields focusing on forensic and clinical toxicology. Internationally recognized and respected experts have contributed to this issue, and articles cover topics such as the current role of online extraction approaches in clinical and forensic toxicology. Extraction is usually the most time-consuming step and, therefore, automation at this step could be an important advancement. The use of online extraction will certainly increase in the near future. Alternative matrices such as dried blood spots, which have increasingly received attention over recent years, are explored in this special issue. The potential and benefits of dried blood spots, the associated limitations and challenges, as well as recent developments and future perspectives are discussed. Furthermore, the use of nails as an alternative matrix in forensic toxicology for drug analysis has received much attention recently, and their current role is highlighted in the editorial. The role of drug testing in hair and oral fluid is also critically discussed in the context of driving under the influence of drugs or drug-facilitated crimes. The number of applications for these matrices will grow in the future once our understanding of sample pretreatment, storage and pharmacokinetics has improved. However, classic matrices are also considered in this special issue. The design and validation of methods for urine drug testing using one-step dilution and direct injection in combination with LC–MS/MS and LC–high-resolution MS are presented. In recent years, analytical methods for urine drug testing have been developed
10.4155/BIO.14.193 © 2014 Future Science Ltd
based on the very simple concept of diluting urine with an internal standard as the sole preparation procedure prior to instrumental analysis. Progress in monitoring alcohol abuse markers such as phosphatidylethanol, which allows differentiation between social drinking and alcohol abuse, is reported in one article. The current position of high-resolution MS for drug quantification in clinical and forensic toxicology is explored. Advantages and limitations of high-resolution MS for quantification in clinical and forensic toxicology are highlighted and the demand for a certain resolution or a specific mass accuracy discussed. Finally, the current role of inductively coupled plasma–MS in clinical and forensic toxicology is examined, including its metallic profile in human toxicology, which is now routinely used and of great importance in clinical and forensic toxicology. This special issue of Bioanalysis highlights the emerging bioanalytical fields in forensic and clinical toxicology. We hope that the reader will gain new insights into this field, and discover new and relevant information for their research projects and daily work. Financial & competing interests disclosure The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this manuscript.
Bioanalysis (2014) 6(17), 2187
Markus R Meyer Author for correspondence: Department of Experimental & Clinical Toxicology, Institute of Experimental & Clinical Pharmacology & Toxicology, Saarland University, D-66421 Homburg (Saar), Germany markus.meyer@ uks.eu
Hans H Maurer Department of Experimental & Clinical Toxicology, Institute of Experimental & Clinical Pharmacology & Toxicology, Saarland University, D-66421 Homburg (Saar), Germany
part of
ISSN 1757-6180
2187
For reprint orders, please contact [email protected]
Forensic and clinical toxicology “This 2014 special issue of Bioanalysis is a collection of articles highlighting
emerging bioanalytical fields focusing on forensic and clinical toxicology. Internationally recognized and respected experts have contributed to this issue, and articles cover topics such as the current role of online extraction approaches in clinical and forensic toxicology.
”
Keywords: clinical toxicology • forensic toxicology • mass spectrometry
This 2014 special issue of Bioanalysis is a collection of articles highlighting emerging bioanalytical fields focusing on forensic and clinical toxicology. Internationally recognized and respected experts have contributed to this issue, and articles cover topics such as the current role of online extraction approaches in clinical and forensic toxicology. Extraction is usually the most time-consuming step and, therefore, automation at this step could be an important advancement. The use of online extraction will certainly increase in the near future. Alternative matrices such as dried blood spots, which have increasingly received attention over recent years, are explored in this special issue. The potential and benefits of dried blood spots, the associated limitations and challenges, as well as recent developments and future perspectives are discussed. Furthermore, the use of nails as an alternative matrix in forensic toxicology for drug analysis has received much attention recently, and their current role is highlighted in the editorial. The role of drug testing in hair and oral fluid is also critically discussed in the context of driving under the influence of drugs or drug-facilitated crimes. The number of applications for these matrices will grow in the future once our understanding of sample pretreatment, storage and pharmacokinetics has improved. However, classic matrices are also considered in this special issue. The design and validation of methods for urine drug testing using one-step dilution and direct injection in combination with LC–MS/MS and LC–high-resolution MS are presented. In recent years, analytical methods for urine drug testing have been developed
10.4155/BIO.14.193 © 2014 Future Science Ltd
based on the very simple concept of diluting urine with an internal standard as the sole preparation procedure prior to instrumental analysis. Progress in monitoring alcohol abuse markers such as phosphatidylethanol, which allows differentiation between social drinking and alcohol abuse, is reported in one article. The current position of high-resolution MS for drug quantification in clinical and forensic toxicology is explored. Advantages and limitations of high-resolution MS for quantification in clinical and forensic toxicology are highlighted and the demand for a certain resolution or a specific mass accuracy discussed. Finally, the current role of inductively coupled plasma–MS in clinical and forensic toxicology is examined, including its metallic profile in human toxicology, which is now routinely used and of great importance in clinical and forensic toxicology. This special issue of Bioanalysis highlights the emerging bioanalytical fields in forensic and clinical toxicology. We hope that the reader will gain new insights into this field, and discover new and relevant information for their research projects and daily work. Financial & competing interests disclosure The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this manuscript.
Bioanalysis (2014) 6(17), 2187
Markus R Meyer Author for correspondence: Department of Experimental & Clinical Toxicology, Institute of Experimental & Clinical Pharmacology & Toxicology, Saarland University, D-66421 Homburg (Saar), Germany markus.meyer@ uks.eu
Hans H Maurer Department of Experimental & Clinical Toxicology, Institute of Experimental & Clinical Pharmacology & Toxicology, Saarland University, D-66421 Homburg (Saar), Germany
part of
ISSN 1757-6180
2187
