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中国肺癌杂志2013年8月第16卷第8期
·417·
C h i n J L u n g C a n c e r, August 2013, Vol.16, No.8
DOI: 10.3779/j.issn.1009-3419.2013.08.05
·临床研究·
半乳凝素-3在非小细胞肺癌中的表达 及相关性研究 刘美燕 杜冰 李春红 赵艳滨 孟庆威 蔡莉 【摘要】 背景与目的 半乳凝素-3(Galectin-3)参与许多生理和病理过程,与肿瘤的发生、发展、转移关系 密切。本研究旨在探讨Galectin-3在非小细胞肺癌(non-small cell lung cancer, NSCLC)中的表达情况及其与临床病理 特征间的关系,探索其在NSCLC发生、发展中的作用。方法 采用S-P免疫组化方法检测62例NSCLC组织和17例正常 肺组织中Galectin-3的表达情况,并用RT-PCR方法在转录水平进行验证,并结合相关的临床病理资料进行分析。结 果 免疫组化结果显示Galectin-3在83.8%(52/62)的NSCLC组织中阳性表达。NSCLC组织中Galectin-3表达阳性率明 2
显高于正常肺组织(χ =7.936, P
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[Expression and related factors of Galectin-3 in non-small cell lung cancer].
背景与目的 半乳凝素-3(Galectin-3)参与许多生理和病理过程,与肿瘤的发生、发展、转移关系密切。本研究旨在探讨Galectin-3在非小细胞肺癌(non-small cell lung cancer, NSCLC)中的表达情况及其与临床病理特征间的关系,探索其在NSCLC发生、发展中的作用...
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