Peter

W Jannace,

Robert

ABSTRACT

A dietary

soy phosphatidylcholine nuclear

(PMNL)

AA release, in normal

PC (27 g) or placebo with PMNL assays Subjects safflower

were (SF,

assays at phagocytosis PMNL

acid

(LA)

arachidonate

(AA)

AA content

(P

threefold

stimulation (r = 0.932)

but not 1 . With

SF

LTB4

triglyceride

LA,

and

generation.

enhanced

con-

Am

killing.

Study

LA,

phospholipid

mentation, The PC LA and

kotriene

Polymorphonuclear acid, arachidonic acid,

leukocyte, phagocytosis,

Candida killing,

alleu-

and

In four

dietary safflower

(LA,

nutrient.

1 8:2n-6),

It is the

oil (SF)

and

principal

soy bean

to be immunosuppressive animals ( 1-9). oils on immune

an w-6 fatty polyunsaturated oil (SY),

in studies

which

of phospholipids.

Thus,

effects

supplement

of an oral

kocyte achidonic (LTB4)

(PMNL) acid generation

Am J C/in Nuir

fatty

acid

been

shown

humans

the

it was

a significant Western

in and

of interest of LA

to study

(AA)

content from

and

release,

stimulated

1992;S6:599-603.

and

Printed

and

=

18 g noodles

blood

above

samples were

different

(P

0.2)

>

(n

from

added

were

the

four

PC,

each

to

SF, or SY blood

The

individuals they

18

added

In this experiment

because

sup-

of either

h postingestion.

from

pooled

and feeding

y of age,

feeding

4), which

=

were

at 48

taken

fed SY

23-63

a single

1.2 kJ/serving.

four

14 d after

at 48 h postingestion

females,

to which and

the

subjects

in a single

and

no

before

PMNLs.

with

4) or SY

at baseline

Signed

three

were

results fed SF

not

statis-

other.

protocol informed-consent

forms

jects in accordance with the ethical Review Board for Human Research,

were

obtained

standards Boston

from

all sub-

ofthe Institutional University Medical

Center.

the

killing),

From the Department of Pathology and Nutrition Pathology Unit, Mallory Institute of Pathology: the Clinical Nutrition Unit, Evans Memorial Department ofClinical Research and Preventive Medicine, University Hospital: and the Boston University School ofMedicine, Boston. 2 Supported in part by the Boston University School of Medicine. 3 Reprints not available. Received November 12, 1991. Accepted for publication March 26, 1992.

relative of major leu-

PMNL

on leukotriene

arB4

PMNLs. in USA.

the the

ingestion

diets

provided

drawn

at 4, 7, and ofthe

stimulated

and

normal

12 g LA and

drawn

PL

was

then

servings

source of dietary is in the form

as a component

(phagocytosis

males

provided

Experimental

of these

fat; ie, phospholipids as phosphatidylcholine fats as SF and SY on polymorphonuclear functions

their The

tically

effects of dietary host defenses (eg,

diet

2. Five

noodles.

and

or phagocytosis) have used neutral fats (ie, as the major or sole component ofthe lipid

in addition to oils, in the conventional

sources of dietary (PC) and neutral

both

is an essential

that the effects through LA.

Most of the studies that have examined lipids on immune functions or nonspecific

used. However, fat consumed

have

involving

It is reasonable to assume functions are mediated

response to mitogen triglycerides or oils)

acid,

before from

1 5 g SF (n

from acid

drawn

g PC or

was

Introduction Linoleic

was

to

five individuals without supple-

18 g PC was administered

generation

for 3

soup

divided

1 .5 kJ/d.

sample

supplements

plemented

B4, humans

blood

supplements.

blood

two

diets

noodle

in three

were reversed. 18 g LA and

A fasting

hiatus,

or

design. Initially, a 2-wk period

ofthe

for LTB4

l992;56:599-603.

given

of the

and

phagocy-

(PL)

initiation a 2-wk

and

normal

The PC was 95% PC choline and its fatty acid composition is mdi-

ingestion after

to

kJ/d.

six males their

placebo

crossover PL. After

the groups provided

0.5

volunteers,

I. PL or PC was

for 3 d in an open fed PC and three

Study KEY WORDS bicans, linoleic

adult

supplemented

a noodle-soup

in Table

daily were

AA

in contrast AA,

either

cated

increased 5.3-fold, and phagocytosis (r

Phospholipid

healthy y ofage,

which 27 g soy PC was added. 5% lysophosphatidylcholine;

PMNL 0.001)