Accepted Manuscript Effect of dental implants on bisphosphonate-related osteonecrosis of the jaws Daniel Holzinger , MD, DMD Rudolf Seemann , MD, DMD, PhD Nadja Matoni , DMD Rolf Ewers , MD, DMD, PhD Werner Millesi , MD, DMD, PhD Arno Wutzl , MD, DMD, PhD PII:
S0278-2391(14)00562-X
DOI:
10.1016/j.joms.2014.04.037
Reference:
YJOMS 56333
To appear in:
Journal of Oral and Maxillofacial Surgery
Received Date: 5 December 2013 Revised Date:
8 April 2014
Accepted Date: 28 April 2014
Please cite this article as: Holzinger D, Seemann R, Matoni N, Ewers R, Millesi W, Wutzl A, Effect of dental implants on bisphosphonate-related osteonecrosis of the jaws, Journal of Oral and Maxillofacial Surgery (2014), doi: 10.1016/j.joms.2014.04.037. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT
Effect of dental implants on bisphosphonate-related osteonecrosis of the jaws
Holzinger MD, DMD; 1Rudolf Seemann MD, DMD, PhD; 1Nadja Matoni DMD; 1Rolf
RI PT
1Daniel
1 University
Clinic of Craniofacial, Maxillofacial and Oral Surgery, Medical University of Vienna, Austria
of Oral and Maxillofacial Surgery and Dentistry, Krankenhaus Hietzing, Wolkersbergenstrasse1,
M AN U
2Institute
SC
Ewers MD, DMD, PhD; 2Werner Millesi MD, DMD, PhD; 1Arno Wutzl MD, DMD, PhD
1130 Vienna, Austria
TE D
Corresponding author: Daniel Holzinger
University Clinic of Craniofacial, Maxillofacial and Oral Surgery
EP
Medical University of Vienna, Austria
Waehringer Guertel 18-20, A-1090 Vienna
AC C
Tel: +43 1 40400 4252, Fax: +43 1 40400 4253, [email protected]
Financial support for research and medical editorial assistance was provided by a CAMLOG Foundation grant, Project AP00508OFF All authors declare that there are no commercial associations, current or in the past five years, that might pose a potential, perceived, or actual conflict of interest. 1
AC C
EP
TE D
M AN U
SC
RI PT
ACCEPTED MANUSCRIPT
2
ACCEPTED MANUSCRIPT
Abstract
Purpose: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a side effect of
RI PT
bisphosphonate therapy. Dental implants are believed to be a risk factor for developing BRONJ. In the present study we analyze the time span of developing BRONJ in patients treated with bisphosphonate and receiving dental implants.
SC
Study design: Patients with dental implants and established BRONJ were evaluated at the department of oral and maxillofacial surgery, Medical University of Vienna. In
M AN U
addition studies from 1978 to 2012 were included in a meta-analysis. Three groups were created: a) implantation before bisphosphonate treatment, b) implantation after bisphosphonate treatment, c) implantation during bisphosphonate treatment. Outcomes were evaluated by linear regression analysis.
Results: Patients who underwent dental implantation during (p
S0278-2391(14)00562-X
DOI:
10.1016/j.joms.2014.04.037
Reference:
YJOMS 56333
To appear in:
Journal of Oral and Maxillofacial Surgery
Received Date: 5 December 2013 Revised Date:
8 April 2014
Accepted Date: 28 April 2014
Please cite this article as: Holzinger D, Seemann R, Matoni N, Ewers R, Millesi W, Wutzl A, Effect of dental implants on bisphosphonate-related osteonecrosis of the jaws, Journal of Oral and Maxillofacial Surgery (2014), doi: 10.1016/j.joms.2014.04.037. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT
Effect of dental implants on bisphosphonate-related osteonecrosis of the jaws
Holzinger MD, DMD; 1Rudolf Seemann MD, DMD, PhD; 1Nadja Matoni DMD; 1Rolf
RI PT
1Daniel
1 University
Clinic of Craniofacial, Maxillofacial and Oral Surgery, Medical University of Vienna, Austria
of Oral and Maxillofacial Surgery and Dentistry, Krankenhaus Hietzing, Wolkersbergenstrasse1,
M AN U
2Institute
SC
Ewers MD, DMD, PhD; 2Werner Millesi MD, DMD, PhD; 1Arno Wutzl MD, DMD, PhD
1130 Vienna, Austria
TE D
Corresponding author: Daniel Holzinger
University Clinic of Craniofacial, Maxillofacial and Oral Surgery
EP
Medical University of Vienna, Austria
Waehringer Guertel 18-20, A-1090 Vienna
AC C
Tel: +43 1 40400 4252, Fax: +43 1 40400 4253, [email protected]
Financial support for research and medical editorial assistance was provided by a CAMLOG Foundation grant, Project AP00508OFF All authors declare that there are no commercial associations, current or in the past five years, that might pose a potential, perceived, or actual conflict of interest. 1
AC C
EP
TE D
M AN U
SC
RI PT
ACCEPTED MANUSCRIPT
2
ACCEPTED MANUSCRIPT
Abstract
Purpose: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a side effect of
RI PT
bisphosphonate therapy. Dental implants are believed to be a risk factor for developing BRONJ. In the present study we analyze the time span of developing BRONJ in patients treated with bisphosphonate and receiving dental implants.
SC
Study design: Patients with dental implants and established BRONJ were evaluated at the department of oral and maxillofacial surgery, Medical University of Vienna. In
M AN U
addition studies from 1978 to 2012 were included in a meta-analysis. Three groups were created: a) implantation before bisphosphonate treatment, b) implantation after bisphosphonate treatment, c) implantation during bisphosphonate treatment. Outcomes were evaluated by linear regression analysis.
Results: Patients who underwent dental implantation during (p
