Accepted Manuscript Comparison of Tricuspid Annular Plane Systolic Excursion in Patients with Atrial Fibrillation vs Sinus Rhythm Yuta Torii, RMS, Kenya Kusunose, MD, PhD, Hirotsugu Yamada, MD, PhD, Susumu Nishio, RMS, Yukina Hirata, RMS, Rie Amano, RT, Masami Yamao, RMS, Mika Bando, MD, Shuji Hayashi, MD, PhD, Masataka Sata, MD, PhD PII:

S0002-9149(15)02199-2

DOI:

10.1016/j.amjcard.2015.10.035

Reference:

AJC 21487

To appear in:

The American Journal of Cardiology

Received Date: 8 September 2015 Revised Date:

21 October 2015

Accepted Date: 22 October 2015

Please cite this article as: Torii Y, Kusunose K, Yamada H, Nishio S, Hirata Y, Amano R, Yamao M, Bando M, Hayashi S, Sata M, Comparison of Tricuspid Annular Plane Systolic Excursion in Patients with Atrial Fibrillation vs Sinus Rhythm, The American Journal of Cardiology (2015), doi: 10.1016/ j.amjcard.2015.10.035. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

ACCEPTED MANUSCRIPT 1

Comparison of Tricuspid Annular Plane Systolic Excursion in Patients with Atrial

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Fibrillation vs Sinus Rhythm Running title: Impact of AF on Echocardiographic Parameters

Yuta Torii, RMS1*, Kenya Kusunose, MD, PhD2*, Hirotsugu Yamada, MD, PhD2,

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Susumu Nishio, RMS1, Yukina Hirata, RMS1, Rie Amano, RT1, Masami Yamao, RMS1,

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Mika Bando, MD2, Shuji Hayashi, MD, PhD2, Masataka Sata, MD, PhD2.

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Ultrasound Examination Center, Tokushima University Hospital, Tokushima, Japan

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Department of Cardiovascular Medicine, Tokushima University Hospital, Tokushima, Japan

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*Co-first authors. Both authors contributed equally to the work.

Address for Correspondence:

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Hirotsugu Yamada, MD, PhD

Department of Cardiovascular Medicine, Tokushima University Hospital, Tokushima, Japan 2-50-1 Kuramoto, Tokushima, Japan TEL: 81-88-633-9311, FAX: 81-88-633-7798 E-mail: [email protected]

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ABSTRACT Echocardiography now plays a central guiding role in the management of patients with atrial

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fibrillation (AF). However, the current guidelines mention little about the presence AF during the assessment of echocardiographic variables in the clinical setting. AF itself may impact on tricuspid annular plane systolic excursion (TAPSE) as a right ventricular systolic function

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compared with sinus rhythm (SR). The aim of this study was to compare and assess the echocardiographic parameters including TAPSE in patients with AF and SR. Between January

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1st, 2013 and September 30th, 2014, AF patients without any cardiovascular disease were retrospectively evaluated using echocardiography. Age, sex and left ventricular ejection fraction (LVEF) matched patients with SR were selected from our database based on a comprehensive history, physical examination and echocardiographic findings. During the study period, we identified 239 AF patients (74±9 years; 65% men) and without any cardiac disease undergoing

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echocardiography. We also included 281 patients in the SR group (74±8 years; 67% men). In all study subjects, TAPSE in AF was smaller than in SR regardless of age (17±3 vs. 20±3 mm,

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