Accepted Manuscript Antibiotic cycling prevents urinary tract infections in spinal cord injury patients and limits the emergence of multidrug resistant organism Claire Poirier, Aurélien Dinh, Jérôme Salomon, Nathalie Grall, Antoine Andremont, Louis Bernard, MD, PhD PII:
S0163-4453(15)00196-6
DOI:
10.1016/j.jinf.2015.06.001
Reference:
YJINF 3553
To appear in:
Journal of Infection
Received Date: 29 May 2015 Revised Date:
2 June 2015
Accepted Date: 3 June 2015
Please cite this article as: Poirier C, Dinh A, Salomon J, Grall N, Andremont A, Bernard L, Antibiotic cycling prevents urinary tract infections in spinal cord injury patients and limits the emergence of multidrug resistant organism, Journal of Infection (2015), doi: 10.1016/j.jinf.2015.06.001. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT Antibiotic cycling prevents urinary tract infections in spinal cord injury patients and limits the emergence of multidrug resistant organism Claire Poirier1,2, Aurélien Dinh3, Jérôme Salomon3, Nathalie Grall4, Antoine Andremont4,
RI PT
Louis Bernard2 (1) Antimicrobialstewardship, CH Victor Jousselin, Dreux Hospital, Dreux, France
François Rabelais University, Tours, France
SC
(2) Infectious Disease department, CHRU Bretonneau, University Hospital of Tours,
(3) Infectious Disease department, CHU Raymond Poincaré, University Hospital of Paris,
M AN U
Versailles Saint Quentin University, Garches, France
(4) Microbiology department, CHU Bichat, University Hospital of Paris, Denis Diderot
TE D
University, Paris, France
Corresponding author:
Pr Louis Bernard, MD, PhD
EP
Infectious Diseases department, University Hospital of Tours,
AC C
2 Boulevard Tonnellé, 37044 Tours, France Tel: 33(0)218370644; Mail: [email protected]
Key words : urinary tract infection, spinal cord injury, antibioc cycling
ACCEPTED MANUSCRIPT Corresponding Author Pr. Louis BERNARD University Hospital of Tours, France Telephone number (+00) 33 2 47 47 37 14 / (+00)33 2 18 37 06 44 Fax number (+00) 33 2 47 47 37 31
RI PT
Email [email protected]
Sir,
SC
We read with great interest the recent study of Ortega et al. regarding the epidemiology and outcome of bacteraemic catheter-acquired urinary tract infection (UTI)[1]. We congratulate the author for this
M AN U
excellent work on this severe disease. We however think that prevention is an important topic to highlight especially in patients with recurrent UTIas population with neurogenic bladder. We evaluated an original prophylactic antibiotic regimen: the WOCA (Weekly Oral Cycling Antibiotic) program.It consists in the alternate weekly administration of an antibiotic to prevent UTI in spinal cord injury (SCI) patients.We studied the effectiveness of WOCA with long follow-up in spinal
TE D
cord injuried population and the incidence of multi drug resistant organisms (MDRO) after a long time exposure (mean: 63 months) to this original regimen in a large cohort of SCI patients with recurrent
EP
UTI.
This was a cross-sectional single center study, conducted at Raymond Poincaréuniversity hospital.
AC C
Three infectious disease physicians reviewed all patients under WOCA regimen on appointment over 3 days.The WOCA study included SCI patients with neurogenic bladder and recurrent UTI: prior to WOCA, all patients had experienced > 4 UTIs per year. They were followed for at least 2 years. UTI was defined as:
- Recent (
S0163-4453(15)00196-6
DOI:
10.1016/j.jinf.2015.06.001
Reference:
YJINF 3553
To appear in:
Journal of Infection
Received Date: 29 May 2015 Revised Date:
2 June 2015
Accepted Date: 3 June 2015
Please cite this article as: Poirier C, Dinh A, Salomon J, Grall N, Andremont A, Bernard L, Antibiotic cycling prevents urinary tract infections in spinal cord injury patients and limits the emergence of multidrug resistant organism, Journal of Infection (2015), doi: 10.1016/j.jinf.2015.06.001. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT Antibiotic cycling prevents urinary tract infections in spinal cord injury patients and limits the emergence of multidrug resistant organism Claire Poirier1,2, Aurélien Dinh3, Jérôme Salomon3, Nathalie Grall4, Antoine Andremont4,
RI PT
Louis Bernard2 (1) Antimicrobialstewardship, CH Victor Jousselin, Dreux Hospital, Dreux, France
François Rabelais University, Tours, France
SC
(2) Infectious Disease department, CHRU Bretonneau, University Hospital of Tours,
(3) Infectious Disease department, CHU Raymond Poincaré, University Hospital of Paris,
M AN U
Versailles Saint Quentin University, Garches, France
(4) Microbiology department, CHU Bichat, University Hospital of Paris, Denis Diderot
TE D
University, Paris, France
Corresponding author:
Pr Louis Bernard, MD, PhD
EP
Infectious Diseases department, University Hospital of Tours,
AC C
2 Boulevard Tonnellé, 37044 Tours, France Tel: 33(0)218370644; Mail: [email protected]
Key words : urinary tract infection, spinal cord injury, antibioc cycling
ACCEPTED MANUSCRIPT Corresponding Author Pr. Louis BERNARD University Hospital of Tours, France Telephone number (+00) 33 2 47 47 37 14 / (+00)33 2 18 37 06 44 Fax number (+00) 33 2 47 47 37 31
RI PT
Email [email protected]
Sir,
SC
We read with great interest the recent study of Ortega et al. regarding the epidemiology and outcome of bacteraemic catheter-acquired urinary tract infection (UTI)[1]. We congratulate the author for this
M AN U
excellent work on this severe disease. We however think that prevention is an important topic to highlight especially in patients with recurrent UTIas population with neurogenic bladder. We evaluated an original prophylactic antibiotic regimen: the WOCA (Weekly Oral Cycling Antibiotic) program.It consists in the alternate weekly administration of an antibiotic to prevent UTI in spinal cord injury (SCI) patients.We studied the effectiveness of WOCA with long follow-up in spinal
TE D
cord injuried population and the incidence of multi drug resistant organisms (MDRO) after a long time exposure (mean: 63 months) to this original regimen in a large cohort of SCI patients with recurrent
EP
UTI.
This was a cross-sectional single center study, conducted at Raymond Poincaréuniversity hospital.
AC C
Three infectious disease physicians reviewed all patients under WOCA regimen on appointment over 3 days.The WOCA study included SCI patients with neurogenic bladder and recurrent UTI: prior to WOCA, all patients had experienced > 4 UTIs per year. They were followed for at least 2 years. UTI was defined as:
- Recent (
