THROMBOSIS RESEARCH 62; 109-l 14,199l 00493848/91 $3.00 + .OO Printed in the USA. Copyright (c) 1991 Pergamon Press pk. All rights reserved.

BRIEF

COMMUNICATION --

IN PLASMA GGE-RELATED CHANGES ‘JC)LLNTEERS IN tiEPA__THY MALE

Krzysztof Krystyna

Lewandowski,

ENDCJGEFdOLlS HEPAR I?d-L I KE

Aleksandra

Maria

Mulitlska,

GrCTIVTTY

Zozui

Zawi 1 ska.

5epartment of Haematolagy, Szkolna Street, Poland

(Received 10.12.1990;

Medical

Academy,

Al-833

Pozna:l,

ihska, S / 12

accepted in revised form 7.1 .1991 by Editor H.A. Vinazzer)

that the nonthrombogenic the due, in to part, presence of heparin-like species on the vascular endothelium. (21 provided evidence that endothelial Harcum et al. Later 09~ prokeoglycans *contain the appropriate monosaccharide sequences antithrombin. required accelerating the action of for Glycosaminoglycans ll3kG) isolated from the endothelial cells and rharacterj zed the extracellular matr i :i were a5 a heparan sulfate, dermatan sulfate, glurut-onic acid9 and chondroitin Weparin-like compounds were 5;ulfate (3, 4, 5jalso found in normal humaf-! circulating blood (.!3> and the presence of glycos~minoglycans-deper-Ident anti codquint activity in the plasma was confirmed as well 17). Nevertheless, the biochemical properties these arid ccl 1t3la.r EiOCITCE! of piafjmatic anticx3aqulantly act ive are substances still not f ul 1y recognized. Xt is possible that disturbances of the synthesis i3r placement of vascular glycosaminoglycans might be responsible for a tendency to arterial Orvenou5 thrombatic disease in humans, expressed in the age over 4G yeat-s. In the present study, we have examined the age-related changes in the plasmatic anti-Iia and anti-X? activities in male tIea thy vnlkxnfeers. In 1973

properties

Damus

of

et al.

blood

II) suggested

vessels

might

MGTERIALS Forty

four

words

: heparin-like

healthy

AND

METHODS

were entered into the study {approved by the 5upervi5ing Ethical Hoard) capon their informed consent. In the ca5e of children their parents' informed consent wss a150 obtained. The volunteer5 were matched

ge

y

male

be

individuals

activity,

109

age-related

changes

110

Vol. 62, Nos. 112

AGE-RELATED CHANGES IN PLASMA...

the following age compartments (mean 47) arid imean 35 ) I 40 - 60 Blocld sampies were collected

to

: 5 over in

to 70 the

~1:) 40 imean 81,

Age-related changes in plasma endogenous heparin-like activity in healthy male volunteers.

THROMBOSIS RESEARCH 62; 109-l 14,199l 00493848/91 $3.00 + .OO Printed in the USA. Copyright (c) 1991 Pergamon Press pk. All rights reserved. BRIEF C...
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