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J Sleep Res. Author manuscript; available in PMC 2017 August 01. Published in final edited form as: J Sleep Res. 2016 August ; 25(4): 404–411. doi:10.1111/jsr.12397.
Actigraphic sleep fragmentation, efficiency, and duration associate with dietary intake in the Rotterdam Study Hassan S Dashti1,2, Lisette A Zuurbier2, Ester de Jonge2,3, Trudy Voortman2, Paul F Jacques4, Stefania Lamon-Fava5, Frank A J L Scheer6,7, Jessica C Kiefte-de Jong2,8, Albert Hofman2, José M Ordovás1,9,10, Oscar H Franco2, and Henning Tiemeier2,11
Author Manuscript
1Nutrition
Author Manuscript
and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, at Tufts University, Boston, MA 2Department of Epidemiology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands 3Department of Internal Medicine, Erasmus MC-University Medical Center, Rotterdam, the Netherlands 4Nutritional Epidemiology Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, at Tufts University, Boston, MA 5Cardiovascular Nutrition Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, at Tufts University, Boston, MA 6Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, Boston, MA 7Division of Sleep Medicine, Harvard Medical School, Boston, MA 8Global Public Health, Leiden University College, The Hague, the Netherlands 9Department of Epidemiology, Centro Nacional Investigaciones Cardiovasculares (CNIC), Madrid, Spain 10Instituto Madrileño de Estudios Avanzados en Alimentación (IMDEA-FOOD), Madrid, Spain 11Department of Psychiatry, Erasmus MC-University Medical Center, Rotterdam, the Netherlands
Abstract Background—Short self-reported sleep duration is associated with dietary intake and this association may partly mediate the link between short sleep and metabolic abnormalities. Subjective sleep measures, however, may be inaccurate and biased. Objective—To evaluate the associations between actigraphic measures of sleep fragmentation, efficiency and duration and energy and macronutrient intakes.
Author Manuscript
Methods—We used data from a subgroup of 439 participants of the population-based cohort, Rotterdam Study. Sleep was assessed using 7-d actigraphy and sleep diaries, and dietary data with a validated food frequency questionnaire. We assessed the associations of actigraphic sleep parameters with dietary intake using multivariable linear regression models.
Corresponding Author: Henning Tiemeier; Department of Epidemiology, Erasmus MC-University Medical Center, P.O.Box 2040, 3000 CA Rotterdam, Netherlands. Tel.:+31107043489; Fax:+31107044657; [email protected]. Author Contribution: H.S.D., L.A.Z., E.dJ., T.V., J.M.O. and H.T. designed research; H.S.D., L.A.Z. and E. dJ. conducted research and analyzed data; H.S.D., L.A.Z., E.dJ., T.V., J.M.O. and H.T. wrote the paper. H.T. had primary responsibility for final content. All authors read and approved the final manuscript. Conflict of interest: Hassan S Dashti, Lisette A Zuurbier, Ester de Jonge, Trudy Voortman, Paul F Jacques, Stefania Lamon-Fava, Frank AJL Scheer, Jessica C Kiefte-de Jong, Albert Hofman, José M Ordovás, Oscar H Franco, and Henning Tiemeier declare no conflicts of interest.
Dashti et al.
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Author Manuscript
Results—Higher sleep fragmentation was associated with 4.19 g lower carbohydrate intake per standard deviation of fragmentation [β (95%CI) =-4.19 (-8.0, -0.3); P=0.03]. Each additional % increase in sleep efficiency was associated with 11.1 kcal lower energy intake [β (95%CI) =-11.1 (-20.6, -1.7); P=0.02]. Furthermore, very short sleep duration (
J Sleep Res. Author manuscript; available in PMC 2017 August 01. Published in final edited form as: J Sleep Res. 2016 August ; 25(4): 404–411. doi:10.1111/jsr.12397.
Actigraphic sleep fragmentation, efficiency, and duration associate with dietary intake in the Rotterdam Study Hassan S Dashti1,2, Lisette A Zuurbier2, Ester de Jonge2,3, Trudy Voortman2, Paul F Jacques4, Stefania Lamon-Fava5, Frank A J L Scheer6,7, Jessica C Kiefte-de Jong2,8, Albert Hofman2, José M Ordovás1,9,10, Oscar H Franco2, and Henning Tiemeier2,11
Author Manuscript
1Nutrition
Author Manuscript
and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, at Tufts University, Boston, MA 2Department of Epidemiology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands 3Department of Internal Medicine, Erasmus MC-University Medical Center, Rotterdam, the Netherlands 4Nutritional Epidemiology Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, at Tufts University, Boston, MA 5Cardiovascular Nutrition Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, at Tufts University, Boston, MA 6Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, Boston, MA 7Division of Sleep Medicine, Harvard Medical School, Boston, MA 8Global Public Health, Leiden University College, The Hague, the Netherlands 9Department of Epidemiology, Centro Nacional Investigaciones Cardiovasculares (CNIC), Madrid, Spain 10Instituto Madrileño de Estudios Avanzados en Alimentación (IMDEA-FOOD), Madrid, Spain 11Department of Psychiatry, Erasmus MC-University Medical Center, Rotterdam, the Netherlands
Abstract Background—Short self-reported sleep duration is associated with dietary intake and this association may partly mediate the link between short sleep and metabolic abnormalities. Subjective sleep measures, however, may be inaccurate and biased. Objective—To evaluate the associations between actigraphic measures of sleep fragmentation, efficiency and duration and energy and macronutrient intakes.
Author Manuscript
Methods—We used data from a subgroup of 439 participants of the population-based cohort, Rotterdam Study. Sleep was assessed using 7-d actigraphy and sleep diaries, and dietary data with a validated food frequency questionnaire. We assessed the associations of actigraphic sleep parameters with dietary intake using multivariable linear regression models.
Corresponding Author: Henning Tiemeier; Department of Epidemiology, Erasmus MC-University Medical Center, P.O.Box 2040, 3000 CA Rotterdam, Netherlands. Tel.:+31107043489; Fax:+31107044657; [email protected]. Author Contribution: H.S.D., L.A.Z., E.dJ., T.V., J.M.O. and H.T. designed research; H.S.D., L.A.Z. and E. dJ. conducted research and analyzed data; H.S.D., L.A.Z., E.dJ., T.V., J.M.O. and H.T. wrote the paper. H.T. had primary responsibility for final content. All authors read and approved the final manuscript. Conflict of interest: Hassan S Dashti, Lisette A Zuurbier, Ester de Jonge, Trudy Voortman, Paul F Jacques, Stefania Lamon-Fava, Frank AJL Scheer, Jessica C Kiefte-de Jong, Albert Hofman, José M Ordovás, Oscar H Franco, and Henning Tiemeier declare no conflicts of interest.
Dashti et al.
Page 2
Author Manuscript
Results—Higher sleep fragmentation was associated with 4.19 g lower carbohydrate intake per standard deviation of fragmentation [β (95%CI) =-4.19 (-8.0, -0.3); P=0.03]. Each additional % increase in sleep efficiency was associated with 11.1 kcal lower energy intake [β (95%CI) =-11.1 (-20.6, -1.7); P=0.02]. Furthermore, very short sleep duration (
