bs_bs_banner

PSANZ 2014 18th Annual Congress Crown Perth, Perth, Western Australia

ORAL ABSTRACTS

2

Oral Abstracts

A400

MATERNAL MELATONIN AS A POTENTIAL FETAL NEUROPROTECTANT IN FETAL GROWTH RESTRICTION Alers NO1,2, Pham Y1, Jenkin G1,2, Miller SL1,2, Wallace EM1,2 1 The Ritchie Centre, Monash Institute of Medical Research, Monash university, Clayton, Victoria, Australia, 2Department of Obstetrics and Gynecology, Southern Clinical School, Monash University, Clayton, Victoria, Australia Email: [email protected] Background: Placental dysfunction and associated fetal growth restriction (FGR) are associated with increased oxidative stress. We hypothesise that maternal melatonin treatment will reduce maternal, fetal and placental oxidative stress, thereby reducing brain injury and improving neurodevelopmental outcomes in FGR-neonates. Method: We undertook an open, single-arm trial of maternal melatonin in women with FGR (estimated fetal weight 0.4 is strongly predictive of early neonatal brain injury. The aim of the current study was to investigate the effect of red cell transfusion in the first 24 hours of life in very preterm infants above and below the cFTOE threshold for early brain injury. Method: Infants ≤ 30 weeks who received an allogeneic red cell transfusion in the first 24 hours were studied. cFTOE was calculated from cerebral tissue oxygenation index (Hamamatsu NIRO 200) and cutaneous oximetry (Masimo) measured over a 1 hour epoch within a 6 hour interval before and after transfusion. Infants were dichotomised by cFTOE 0.4 (high risk [n = 4]). Results: Clinical characteristics between the cFTOE groups were similar. Red cell transfusion resulted in an increase in Hb concentration in both groups (p < 0.001) with post-transfusion Hb similar between the groups. A reduction in cFTOE post-transfusion was seen in the high-risk group alone

TRACT-BASED SPATIAL STATISTICS ANALYSIS OF DIFFUSION TENSOR DATA OF THE BRAIN IN VERY PRETERM 7 YEAR-OLDS Kelly CE1, Thompson DK1, Leemans A2, Adamson C1, Chen J1, Inder TE3, Cheong JLY1,4, Doyle LW1,4, Anderson PJ1,5 1 Murdoch Childrens Research Institute, Melbourne, Australia, 2Image Sciences Institute, University Medical Center Utrect, The Netherlands, 3 Brigham and Women’s Hospital, Boston, United States, 4Royal Women’s Hospital, Melbourne, Australia, 5Department of Paediatrics, University of Melbourne, Melbourne, Australia Email: [email protected] Background: Very preterm birth (VPT,

Abstracts of the 18th Congress of the Perinatal Society of Australia and New Zealand (PSANZ), 6-9 April 2014, Crown Perth, Perth, Western Australia.

Abstracts of the 18th Congress of the Perinatal Society of Australia and New Zealand (PSANZ), 6-9 April 2014, Crown Perth, Perth, Western Australia. - PDF Download Free
1MB Sizes 2 Downloads 6 Views