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Otol Neurotol. Author manuscript; available in PMC 2017 July 01. Published in final edited form as: Otol Neurotol. 2016 July ; 37(6): 805–812. doi:10.1097/MAO.0000000000001045.

Double-blind sham-controlled cross-over trial of repetitive transcranial magnetic stimulation for Mal de Debarquement Syndrome Yoon-Hee Cha1,2, Choi Deblieck2, and Allan D. Wu2

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1

Laureate Institute for Brain Research, Tulsa, OK., USA

2

University of California Los Angeles, Los Angeles, CA., USA

Abstract Objective—To determine whether the chronic rocking dizziness that occurs in mal de debarquement syndrome (MdDS) can be suppressed with repetitive transcranial magnetic stimulation (rTMS) beyond the treatment period. Methods—We performed a prospective randomized double-blind sham controlled cross-over trial of five-days of rTMS utilizing high frequency (10Hz) stimulation over the left dorsolateral prefrontal cortex (DLPFC).

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Results—Eight right-handed women (44.5 (sd 7.0) years) with classical motion-triggered MdDS (mean duration 42.1 (sd 13.2) months) participated. Group level mixed effects repeated measures ANOVA showed improvement in our primary outcome measure, the Dizziness Handicap Inventory (DHI) at Post TMS Weeks 1, 3, and 4 (p