Original Article

Does Phase 1 Trial Enrollment Preclude Quality End-of-Life Care? Phase 1 Trial Enrollment and End-of-Life Care Characteristics in Children With Cancer Deena R. Levine, MD1; Liza-Marie Johnson, MD, MPH, MSB1; Belinda N. Mandrell, PhD, RN2; Jie Yang, PhD3; Nancy K. West, MSN, RN2; Pamela S. Hinds, PhD, RN, FAAN4; and Justin N. Baker, MD1

BACKGROUND: End-of-life care (EOLC) discussions and treatment-related decisions, including phase 1 trial enrollment, in patients with incurable disease are complex and can influence the quality of EOLC received. The current study was conducted in pediatric oncology patients to determine whether end-of-life characteristics differed between those who were and were not enrolled in a phase 1 trial. METHODS: The authors reviewed the medical records of 380 pediatric oncology patients (aged

Does phase 1 trial enrollment preclude quality end-of-life care? Phase 1 trial enrollment and end-of-life care characteristics in children with cancer.

End-of-life care (EOLC) discussions and treatment-related decisions, including phase 1 trial enrollment, in patients with incurable disease are comple...
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