Original article 285

Does Fibrin Glue Cause Foreign Body Reactions? M. $anaF, H. Dogrnyoll, A. Gürpinar l , Ö. Yerci 2 of Pedialric Surgery and 2Palhology, Facully of Medicine, U1udag University, Bursa, Turkey

Summary The study was performed in 20 Wistar rats. Approximately 4 mm perforations were created in the left colon of ten rats to which fibrin g!ue was applied (Group D). The contral group had the same injury without any therapeutic or surgical measures (Group K). Of the 20 rats in both graups none died during the postoperati\'e period. All animals sacrificed on the II th postoperati"e day. All ten rats of Group D displayed inflammatory foreign bod)' reaction . The contro! group showed no such reaction.

Key words Fibrin glue - Foreign body reaction

Resume Chez 10 rats Wistar une perforation d 'environ 4 mm fut pratiquee au niveau du colon gauche et refermee avec du tissucolle (colle de fibrine) (groupe de recherche D). Chez un groupe de contr6le (groupe K), la perforation ne fut pas traitee chez 10 animaux. Tous les animaux des deux groupes survecurent a l'operation. Les rats furent sacrifies au lleme jour po t-operatoire. Les recherches histopatholo-

Introduetion Fibrin glue has recenUy been used in various surgical fields, on the assumption that it causes only very few foreign bod)' reactions or none at all (I, 2, 3,

Does fibrin glue cause foreign body reactions?

The study was performed in 20 Wistar rats. Approximately 4 mm perforations were created in the left colon of ten rats to which fibrin glue was applied...
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