CLINICAL RESEARCH e-ISSN 1643-3750 © Med Sci Monit, 2014; 20: 2651-2657 DOI: 10.12659/MSM.892230

Does Airway Surgery Lower Serum Lipid Levels in Obstructive Sleep Apnea Patients? A Retrospective Case Review

Received: 2014.08.13 Accepted: 2014.12.02 Published: 2014.12.13

Authors’ Contribution: Study Design  A Data Collection  B Analysis  C Statistical Data Interpretation  D Manuscript Preparation  E Literature Search  F Collection  G Funds

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Li Li* Xiaojun Zhan* Ningyu Wang Jayant Marian Pinto Xiaohui Ge Chunyan Wang Jun Tian Yongxiang Wei

1 Department of Otolaryngology Head and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China 2 Department of Otolaryngology Head and Neck Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China 3 Section of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Chicago, Chicago, IL, U.S.A.

Corresponding Author: Source of support:

* Co-first author. These authors contributed equally to this work Yongxiang Wei, e-mail: [email protected] The Capital Health Research and Development Fund, Special Grants, 2011-2003-05, Government of China. JMP received funding from the National Institute on Aging (AG036762)



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Conclusions:

Obstructive sleep apnea (OSA) is tightly linked to increased cardiovascular disease. Surgery is an important method to treat OSA, but its effect on serum lipid levels in OSA patients is unknown. We aimed to evaluate the effect of upper airway surgery on lipid profiles. We performed a retrospective review of 113 adult patients with OSA who underwent surgery (nasal or uvulopalatopharyngoplasty [UPPP]) at a major, urban, academic hospital in Beijing from 2012 to 2013 who had preoperative and postoperative serum lipid profiles. Serum TC (4.86±0.74 to 4.69±0.71) and LP(a) (median 18.50 to 10.90) all decreased significantly post-operatively (P0.05, all). For UPPP patients (n=51), serum TC, HDL and LP(a) improved (P=0.01, 0.01,

Does airway surgery lower serum lipid levels in obstructive sleep apnea patients? A retrospective case review.

Obstructive sleep apnea (OSA) is tightly linked to increased cardiovascular disease. Surgery is an important method to treat OSA, but its effect on se...
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