Original Paper
Nephron 1992:60:17-24
a Department of Medicine, Manchester Royal Infirmary, Manchester; b Departments of Haematology and Nuclear Medicine, Hammersmith Hospital, London, UK
Key Words Bone marrow transplantation Ciclosporin Renal haemodynamics Nephrotoxicity
Disturbance in Renal Haemodynamics and Physiology in Bone Marrow Transplant Recipients Treated with Ciclosporin A
Abstract The vascular disturbance associated with ciclosporin (CS) nephrotoxicity is poorly defined in both the normal and transplanted human kidney. Six bone marrow transplant recipients were studied before, during and after administra tion of CS. By analysis of time activity curves and clearance of Tc-99m DTPA, renal blood flow (RBF), filtration fraction (FF) and GFR were shown to fall on CS (GFR: p < 0.001; RBF, FF: p
Nephron 1992:60:17-24
a Department of Medicine, Manchester Royal Infirmary, Manchester; b Departments of Haematology and Nuclear Medicine, Hammersmith Hospital, London, UK
Key Words Bone marrow transplantation Ciclosporin Renal haemodynamics Nephrotoxicity
Disturbance in Renal Haemodynamics and Physiology in Bone Marrow Transplant Recipients Treated with Ciclosporin A
Abstract The vascular disturbance associated with ciclosporin (CS) nephrotoxicity is poorly defined in both the normal and transplanted human kidney. Six bone marrow transplant recipients were studied before, during and after administra tion of CS. By analysis of time activity curves and clearance of Tc-99m DTPA, renal blood flow (RBF), filtration fraction (FF) and GFR were shown to fall on CS (GFR: p < 0.001; RBF, FF: p
