Distribution of tocopherols in human plasma and red blood cells1’ Ching
K.
Chow,
Ph.D.
ABSTRACT
The
red
blood
cells.
and
from
0.9
1.6)
g/ml
amount
0.3
in plasma
blood
cells.
and
-y form
and
69%.
of various
1.4) tg/ml
and
ig/ml)
to be localized
in
red
0.1
in the
in red
blood
to
(mean
blood
plasma
system. and
membrane
American
Journal
of Clinical
Downloaded from https://academic.oup.com/ajcn/article-abstract/28/7/756/4716490 by East Carolina University user on 04 June 2018
red
determined
from cells.
6.6
No
g/ml
accounted
for 83%
recovery
fraction.
All Am.
ranged
from
blood
in plasma
J.
Clin.
Only
87%
28:
Nutr.
was
plasma
or
in red blood
4C-cs-tocopherol in the
a minute
1-tocopherol
in either
a-tocopherol
and
in plasma,
0.7 to 2.7 (mean
cells.
and
plasma
g/ml
and
detected
of added
cells.
9.6)
in red was
human
(mean
y-tocotrienol
#{244}-tocotrienol
The
15.0
-y-Tocopherol
0.24)
blood
in normal
to
$-tocopherol,
cells.
In part due to a close relationship between the incidence of coronary heart disease and saturated fat intake, there has been a marked increase in the consumption of polyunsaturated oils of plant origin during the past decades. For example, per capita distribution of vegetable oils in food products in the United States increased from 22.7 lbs in 1950 to 39.4 lbs in 1970, while the animal fats decreased from 23.2 lbs to 14.0 lbs during the same period (1). In contrast to animal fats, vegetable oils contain a high concentration of tocopherols, which are usually dominated by the biologically less active forms of vitamin E, i.e., non-a-tocopherols. Based on the content of individual tocopherols in the major edible fats and oils of 1970 (Table 1) 7-tocopherol would probably constitute over 50% of total tocopherol intake in American population, while a- and 6-tocopherol account for approximately 20% each. This estimation corresponds well to the tocopherol content in representating American meals analyzed by Bieri and PoukkaEvarts (11). Since vitamin E status in human population has been assessed in terms of a-tocopherol levels in blood plasma, whereas non-a-tocopherols appear to be the major components in the diet, the contribution of various members of the tocopherol family, including tocotrienols, to
The
0.4
a form
13% in each for
was
ranged
of a-tocotrienol,
tocopherols,
represented respectively,
from
of each
but none
Of the total
tocopherols
concentrations
to 1.8 (mean
in plasma (
90 >90 >90
53.4 8.9 3.8 3.1 1.4 1.0 0.7 0.7 0.6
56-160 30-81 53-162 1-4 20-32 33-73 0 25-49 5-15
4-18 51-67 11-24 14-67 48-61 28-50
I ndivid
ualtoc
i
!±...
i:T::..
53.4
757
States oftotal
1:i:2__
Ref
#{244}-T 6T3
K.
Chow,
Ph.D.
ABSTRACT
The
red
blood
cells.
and
from
0.9
1.6)
g/ml
amount
0.3
in plasma
blood
cells.
and
-y form
and
69%.
of various
1.4) tg/ml
and
ig/ml)
to be localized
in
red
0.1
in the
in red
blood
to
(mean
blood
plasma
system. and
membrane
American
Journal
of Clinical
Downloaded from https://academic.oup.com/ajcn/article-abstract/28/7/756/4716490 by East Carolina University user on 04 June 2018
red
determined
from cells.
6.6
No
g/ml
accounted
for 83%
recovery
fraction.
All Am.
ranged
from
blood
in plasma
J.
Clin.
Only
87%
28:
Nutr.
was
plasma
or
in red blood
4C-cs-tocopherol in the
a minute
1-tocopherol
in either
a-tocopherol
and
in plasma,
0.7 to 2.7 (mean
cells.
and
plasma
g/ml
and
detected
of added
cells.
9.6)
in red was
human
(mean
y-tocotrienol
#{244}-tocotrienol
The
15.0
-y-Tocopherol
0.24)
blood
in normal
to
$-tocopherol,
cells.
In part due to a close relationship between the incidence of coronary heart disease and saturated fat intake, there has been a marked increase in the consumption of polyunsaturated oils of plant origin during the past decades. For example, per capita distribution of vegetable oils in food products in the United States increased from 22.7 lbs in 1950 to 39.4 lbs in 1970, while the animal fats decreased from 23.2 lbs to 14.0 lbs during the same period (1). In contrast to animal fats, vegetable oils contain a high concentration of tocopherols, which are usually dominated by the biologically less active forms of vitamin E, i.e., non-a-tocopherols. Based on the content of individual tocopherols in the major edible fats and oils of 1970 (Table 1) 7-tocopherol would probably constitute over 50% of total tocopherol intake in American population, while a- and 6-tocopherol account for approximately 20% each. This estimation corresponds well to the tocopherol content in representating American meals analyzed by Bieri and PoukkaEvarts (11). Since vitamin E status in human population has been assessed in terms of a-tocopherol levels in blood plasma, whereas non-a-tocopherols appear to be the major components in the diet, the contribution of various members of the tocopherol family, including tocotrienols, to
The
0.4
a form
13% in each for
was
ranged
of a-tocotrienol,
tocopherols,
represented respectively,
from
of each
but none
Of the total
tocopherols
concentrations
to 1.8 (mean
in plasma (
90 >90 >90
53.4 8.9 3.8 3.1 1.4 1.0 0.7 0.7 0.6
56-160 30-81 53-162 1-4 20-32 33-73 0 25-49 5-15
4-18 51-67 11-24 14-67 48-61 28-50
I ndivid
ualtoc
i
!±...
i:T::..
53.4
757
States oftotal
1:i:2__
Ref
#{244}-T 6T3
