RESEARCH ARTICLE
Digital Evaluation of Orbital Cyst Associated with Microphthalmos: Characteristics and Their Relationship with Orbital Volume Ying Cui1,2,3, Yue Zhang1,2,3, Qinglin Chang4, Junfang Xian4, Zhijia Hou1,2,3, Dongmei Li1,2,3* 1 Beijing Tongren Eye Center, Capital Medical University, Beijing, China, 2 Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China, 3 Beijing Ophthalmology & Visual Science Key Lab, Capital Medical University, Beijing, China, 4 Department of Medical Imaging Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China * [email protected]
a11111
Abstract Purpose OPEN ACCESS
To study the characteristics of orbital cyst associated with microphthalmos in a group of Chinese patients, and to analyze the relationship between orbital cyst and orbital volume.
Citation: Cui Y, Zhang Y, Chang Q, Xian J, Hou Z, Li D (2016) Digital Evaluation of Orbital Cyst Associated with Microphthalmos: Characteristics and Their Relationship with Orbital Volume. PLoS ONE 11(6): e0157819. doi:10.1371/journal.pone.0157819
Design
Editor: Haotian Lin, Sun Yat-sen University, CHINA
Participants
Received: October 21, 2015
120 patients who were diagnosed as unilateral clinical blind microphthalmos, in which 20 patients had orbital cyst in the affected eye.
Accepted: June 6, 2016
Cross-sectional comparative study.
Published: June 17, 2016 Copyright: © 2016 Cui et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information files. Funding: This work was supported by the Beijing Municipal Science & Technology Commission (No. Z131107002213002) to Dr. Dongmei Li, http://www. bjkw.gov.cn. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared that no competing interests exist.
Method Participants had computed tomography (CT) scan. CT images were analyzed with a computer-aided software.
Main Outcome Measures Volume and position of orbital cyst, microphthalmic to contralateral ratio (MCR) of orbital volume, height and depth and orbital rim displacement.
Results 38.1% of the cysts located anterior to or at the equator of the globe, 75% of which located infratemporally and all of which were outside the muscle cone. Most (84.6%) of the posterior cysts were inside the muscle cone. The anterior cysts were larger than the posterior cysts (p = 0.005). MCR of orbital volume (p
Digital Evaluation of Orbital Cyst Associated with Microphthalmos: Characteristics and Their Relationship with Orbital Volume Ying Cui1,2,3, Yue Zhang1,2,3, Qinglin Chang4, Junfang Xian4, Zhijia Hou1,2,3, Dongmei Li1,2,3* 1 Beijing Tongren Eye Center, Capital Medical University, Beijing, China, 2 Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China, 3 Beijing Ophthalmology & Visual Science Key Lab, Capital Medical University, Beijing, China, 4 Department of Medical Imaging Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China * [email protected]
a11111
Abstract Purpose OPEN ACCESS
To study the characteristics of orbital cyst associated with microphthalmos in a group of Chinese patients, and to analyze the relationship between orbital cyst and orbital volume.
Citation: Cui Y, Zhang Y, Chang Q, Xian J, Hou Z, Li D (2016) Digital Evaluation of Orbital Cyst Associated with Microphthalmos: Characteristics and Their Relationship with Orbital Volume. PLoS ONE 11(6): e0157819. doi:10.1371/journal.pone.0157819
Design
Editor: Haotian Lin, Sun Yat-sen University, CHINA
Participants
Received: October 21, 2015
120 patients who were diagnosed as unilateral clinical blind microphthalmos, in which 20 patients had orbital cyst in the affected eye.
Accepted: June 6, 2016
Cross-sectional comparative study.
Published: June 17, 2016 Copyright: © 2016 Cui et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information files. Funding: This work was supported by the Beijing Municipal Science & Technology Commission (No. Z131107002213002) to Dr. Dongmei Li, http://www. bjkw.gov.cn. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared that no competing interests exist.
Method Participants had computed tomography (CT) scan. CT images were analyzed with a computer-aided software.
Main Outcome Measures Volume and position of orbital cyst, microphthalmic to contralateral ratio (MCR) of orbital volume, height and depth and orbital rim displacement.
Results 38.1% of the cysts located anterior to or at the equator of the globe, 75% of which located infratemporally and all of which were outside the muscle cone. Most (84.6%) of the posterior cysts were inside the muscle cone. The anterior cysts were larger than the posterior cysts (p = 0.005). MCR of orbital volume (p
