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Diffusion tensor imaging study in Duchenne muscular dystrophy Ya Fu1, Yuru Dong2, Chao Zhang2, Yu Sun1, Shu Zhang1, Xuetao Mu2, Hong Wang2, Weihai Xu3, Shiwen Wu1 1

Department of Neurology, 2Department of MRI, General Hospital of Chinese People’s Armed Police Forces, Beijing 100039, China; 3Department

of Neurology, Peking Union Medical College Hospital and Chinese Academy of Medical Science, Beijing 100005, China Contributions: (I) Conception and design: S Wu, Y Fu, X Mu; (II) Administrative support: H Wang, W Xu, S Wu; (III) Provision of study materials or patients: S Wu, Y Sun, S Zhang; (IV) Collection and assembly of data: Y Dong, C Zhang, Y Sun, S Zhang, X Mu, Y Fu; (V) Data analysis and interpretation: Y Dong, C Zhang, X Mu, Y Fu; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. Correspondence to: Shiwen Wu. Department of Neurology, General Hospital of Chinese People’s Armed Police Forces, 69 Yongding Road, Haidian District, Beijing 100039, China. Email: [email protected]

Background: Duchenne muscular dystrophy (DMD) is a progressive muscle disorder associated with an intellectual deficit which is non-progressive. The aim of this study was to investigate brain microstructural changes in DMD and to explore the relationship between such changes and cognitive impairment.

Methods: All participants (12 DMD patients, 14 age-matched healthy boys), intelligence quotients (IQs) [both full (FIQ) and verbal (VIQ)] were evaluated using the Wechsler intelligence scale for children China revised (WISCCR) edition, and brain gray matter (GM) and white matter (WM) changes were mapped using diffusion tensor imaging (DTI) with fractional anisotropy (FA). The differences between groups were analyzed using the t-test and the association of cognition with neuroimaging parameters was evaluated using Pearson’s correlation coefficient.

Results: Compared to the normal controls, the DMD group had lower FIQ (82.0±15.39 vs. 120.21±16.06) and significantly lower splenium of corpus callosum (CC) FA values (P

Diffusion tensor imaging study in Duchenne muscular dystrophy.

Duchenne muscular dystrophy (DMD) is a progressive muscle disorder associated with an intellectual deficit which is non-progressive. The aim of this s...
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