Neuroradiology DOI 10.1007/s00234-014-1473-5

FUNCTIONAL NEURORADIOLOGY

Diffusion tensor imaging parameters’ changes of cerebellar hemispheres in Parkinson’s disease Enricomaria Mormina & Alessandro Arrigo & Alessandro Calamuneri & Francesca Granata & Angelo Quartarone & Maria F. Ghilardi & Matilde Inglese & Alessandro Di Rocco & Demetrio Milardi & Giuseppe P. Anastasi & Michele Gaeta

Received: 28 August 2014 / Accepted: 24 November 2014 # Springer-Verlag Berlin Heidelberg 2014

Abstract Introduction Studies with diffusion tensor imaging (DTI) analysis have produced conflicting information about the involvement of the cerebellar hemispheres in Parkinson’s disease (PD). We, thus, used a new approach for the analysis of DTI parameters in order to ascertain the involvement of the cerebellum in PD. Methods We performed a fiber tract-based analysis of cerebellar peduncles and cerebellar hemispheres in 16 healthy subjects and in 16 PD patients with more than 5 years duration of disease, using a 3T MRI scanner and a constrained spherical deconvolution (CSD) approach for tractographic reconstructions. In addition, we performed statistical analysis of DTI parameters and fractional anisotropy (FA) XYZ direction samplings. Results We found a statistically significant decrement of FA values in PD patients compared to controls (p0.05) (Table 2). Compared to healthy group, PD patients showed decreased FA mean (t=−1.779, df=32, p0.05).

Discussion In this study, we evaluated several DTI parameters in cerebellar hemispheres of PD patients compared to age-matched control group and found statistically significant decrement in FA values

Table 3 Analysis of cerebellar hemispheres’ DTI parameters of patients with PD and healthy subjects DTI parameters

PD patients

Healthy subjects

Number of tracts Tract length (mm) Tract volume (mm3) FA FA X FA Y FA Z ADC ADC X

1060±99.8 62.8±17.64 103674.6±17103.21 0.243±0.01* 0.226±0.01 0.261±0.01** 0.247±0.02 0.844±0.05 0.885±0.04

1117.6±121.88 59.2±19.06 107526.4±23390.32 0.259±0.01* 0.237±0.01 0.291±0.02** 0.236±0.01 0.828±0.05 0.878±0.06

0.914±0.07 0.874±0.03

0.915±0.07 0.989±0.17

ADC Y ADC Z

Note—Data are mean±standard deviation for number of tracts, tract length, tract volume, fractional anisotropy (FA), and XYZ direction sampling of FA and ADC. ADC values are reported multiplied by 10−3 mm2 /s *p

Diffusion tensor imaging parameters' changes of cerebellar hemispheres in Parkinson's disease.

Studies with diffusion tensor imaging (DTI) analysis have produced conflicting information about the involvement of the cerebellar hemispheres in Park...
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