Neuroradiology DOI 10.1007/s00234-014-1473-5


Diffusion tensor imaging parameters’ changes of cerebellar hemispheres in Parkinson’s disease Enricomaria Mormina & Alessandro Arrigo & Alessandro Calamuneri & Francesca Granata & Angelo Quartarone & Maria F. Ghilardi & Matilde Inglese & Alessandro Di Rocco & Demetrio Milardi & Giuseppe P. Anastasi & Michele Gaeta

Received: 28 August 2014 / Accepted: 24 November 2014 # Springer-Verlag Berlin Heidelberg 2014

Abstract Introduction Studies with diffusion tensor imaging (DTI) analysis have produced conflicting information about the involvement of the cerebellar hemispheres in Parkinson’s disease (PD). We, thus, used a new approach for the analysis of DTI parameters in order to ascertain the involvement of the cerebellum in PD. Methods We performed a fiber tract-based analysis of cerebellar peduncles and cerebellar hemispheres in 16 healthy subjects and in 16 PD patients with more than 5 years duration of disease, using a 3T MRI scanner and a constrained spherical deconvolution (CSD) approach for tractographic reconstructions. In addition, we performed statistical analysis of DTI parameters and fractional anisotropy (FA) XYZ direction samplings. Results We found a statistically significant decrement of FA values in PD patients compared to controls (p0.05) (Table 2). Compared to healthy group, PD patients showed decreased FA mean (t=−1.779, df=32, p0.05).

Discussion In this study, we evaluated several DTI parameters in cerebellar hemispheres of PD patients compared to age-matched control group and found statistically significant decrement in FA values

Table 3 Analysis of cerebellar hemispheres’ DTI parameters of patients with PD and healthy subjects DTI parameters

PD patients

Healthy subjects

Number of tracts Tract length (mm) Tract volume (mm3) FA FA X FA Y FA Z ADC ADC X

1060±99.8 62.8±17.64 103674.6±17103.21 0.243±0.01* 0.226±0.01 0.261±0.01** 0.247±0.02 0.844±0.05 0.885±0.04

1117.6±121.88 59.2±19.06 107526.4±23390.32 0.259±0.01* 0.237±0.01 0.291±0.02** 0.236±0.01 0.828±0.05 0.878±0.06

0.914±0.07 0.874±0.03

0.915±0.07 0.989±0.17


Note—Data are mean±standard deviation for number of tracts, tract length, tract volume, fractional anisotropy (FA), and XYZ direction sampling of FA and ADC. ADC values are reported multiplied by 10−3 mm2 /s *p

Diffusion tensor imaging parameters' changes of cerebellar hemispheres in Parkinson's disease.

Studies with diffusion tensor imaging (DTI) analysis have produced conflicting information about the involvement of the cerebellar hemispheres in Park...
2MB Sizes 3 Downloads 23 Views

Recommend Documents

Longitudinal cerebellar diffusion tensor imaging changes in posterior fossa syndrome.
Posterior fossa syndrome is a severe transient loss of language that frequently complicates resection of tumors of the cerebellum. The associated pathophysiology and relevant anatomy to this language deficit remains controversial. We performed a retr

Investigation of Motor Cortical Plasticity and Corticospinal Tract Diffusion Tensor Imaging in Patients with Parkinsons Disease and Essential Tremor.
Parkinson's disease (PD) and essential tremor (ET) are characterized with motor dysfunctions. Motor circuit dysfunctions can be complementarily investigated by paired associative stimulation (PAS)-induced long-term potentiation (LTP)-like plasticity

Age-related changes of the diffusion tensor imaging parameters of the normal cervical spinal cord.
The diffusion tensor imaging (DTI) parameters of the cervical spinal cord (CSC) changes with age. However, previous studies only examined specific CSC areas.

Preoperative weakness and demyelination of the corticospinal tract in meningioma patients : changes in diffusion parameters using diffusion tensor imaging.
Differentiation of demyelination in white matter from axonal damage can be determined using diffusion tensor imaging (DTI). In this study using meningioma patients an attempt was made to evaluate the relationship between preoperative weakness and the

Improvement of Diffusion Tensor Imaging (DTI) Parameters with Decoppering Treatment in Wilson's Disease.
This study was undertaken to analyse serially the effects of decoppering therapy on the clinical features, disability and MRI brain including DTI metrics in patients with Wilson's disease.

Hippocampal diffusion tensor imaging microstructural changes in vascular dementia.
To explore microstructural integrity of hippocampus in vascular dementia (VD) using DTI. Twenty-five individuals with VD, without magnetic resonance imaging (MRI) evidence of gray matter pathology, and 25 matched healthy control (HC) individuals unde

Diffusion tensor imaging of the nigrostriatal fibers in Parkinson's disease.
Parkinson's disease (PD) is histopathologically characterized by the loss of dopamine neurons in the substantia nigra pars compacta. The depletion of these neurons is thought to reduce the dopaminergic function of the nigrostriatal pathway, as well a

Novel diffusion tensor imaging findings in Krabbe disease.
Krabbe disease is a lysosomal disorder that primarily affects myelin. Diffusion tensor imaging (DTI) provides quantitative information about the white matter organization and integrity. Radial diffusivity (RD) reflects myelin injury selectively.

Brain MR diffusion tensor imaging in Kennedy's disease.
Kennedy's disease (KD) is a progressive degenerative disorder affecting lower motor neurons. We investigated the correlation between disease severity and whole brain white matter microstructure, including upper motor neuron tracts, by using diffusion

3T magnetic resonance diffusion tensor imaging in chronic kidney disease.
To investigate the relationship of apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values with renal function on 3T diffusion tensor imaging (DTI) in chronic kidney disease.