Just Accepted by The Journal of Maternal-Fetal & Neonatal Medicine Differential Oxidative Stress levels in mothers with Preeclampsia delivering Male and Female Babies Suchitra Roy, Madhavi Dhobale, Kamini Dangat, Savita Mehendale, Sanjay Lalwani, Sadhana Joshi doi: 10.3109/14767058.2014.974537 Abstract

J Matern Fetal Neonatal Med Downloaded from informahealthcare.com by University of Miami on 12/31/14 For personal use only.

Objectives: Increased oxidative stress is known to be associated with pregnancy complications like preeclampsia (PE). We hypothesize that increased maternal oxidative stress may differentially affect/program the pregnancy outcome during early postnatal periods in male and female babies. Materials and methods: One hundred three healthy pregnant women (gestation ≥37 weeks) were recruited for the normotensive control group and 57 women with term-preeclampsia (T-PE; gestation ≥37 weeks) and 28 women with preterm- preeclampsia (PT-PE; gestation 6 hour apart.

4

J Matern Fetal Neonatal Med Downloaded from informahealthcare.com by University of Miami on 12/31/14 For personal use only.

This diagnosis of PE has been reported in a series of our studies [24, 25, 26, 17]. The gestational age in the current study was determined by last menstrual period (LMP) and ultrasound. The research protocols and consent forms were approved by the Institutional Ethical Committee. All the women consented to participate in the study and signed written consent forms. Women were excluded from the study if there was evidence of other pregnancy complications such as chronic hypertension, type I or type II diabetes mellitus, seizure disorder and renal or liver disease. The women recruited in the study came from a background where traditional values of this population do not allow smoking or drinking in women. This was confirmed when the women were interviewed for demographic and nutritional history. The statistical power was calculated based on our earlier study in preeclampsia [18] where we have reported significant group differences in homocysteine levels from 49 preeclamptic and 57 normotensive women (p

Differential oxidative stress levels in mothers with preeclampsia delivering male and female babies.

Increased oxidative stress is known to be associated with pregnancy complications like preeclampsia (PE). We hypothesize that increased maternal oxida...
1MB Sizes 0 Downloads 6 Views