RESEARCH ARTICLE
Diagnosis of HIV-Associated Oral Lesions in Relation to Early versus Delayed Antiretroviral Therapy: Results from the CIPRA HT001 Trial Ashita S. Batavia1*, Rode Secours2, Patrice Espinosa3, Marc Antoine Jean Juste2, Patrice Severe2, Jean William Pape1,2, Daniel W. Fitzgerald1 1 Weill Cornell Medical Center, New York, New York, United States of America, 2 Groupe Haitien d’Etude du Sarcome de Kaposi et des Infections Opportunistes (GHESKIO), Port-au-Prince, Haiti, 3 University of California San Francisco School of Dentistry, San Francisco, California, United States of America * [email protected]
Abstract OPEN ACCESS Citation: Batavia AS, Secours R, Espinosa P, Jean Juste MA, Severe P, Pape JW, et al. (2016) Diagnosis of HIV-Associated Oral Lesions in Relation to Early versus Delayed Antiretroviral Therapy: Results from the CIPRA HT001 Trial. PLoS ONE 11 (3): e0150656. doi:10.1371/journal.pone.0150656 Editor: Graciela Andrei, Rega Institute for Medical Research, BELGIUM Received: July 10, 2015 Accepted: February 16, 2016 Published: March 1, 2016 Copyright: © 2016 Batavia et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information files.
Oral mucosal lesions that are associated with HIV infection can play an important role in guiding the decision to initiate antiretroviral therapy (ART). The incidence of these lesions relative to the timing of ART initiation has not been well characterized. A randomized controlled clinical trial was conducted at the GHESKIO Center in Port-au-Prince, Haiti between 2004 and 2009. 816 HIV-infected ART-naïve participants with CD4 T cell counts between 200 and 350 cells/mm3 were randomized to either immediate ART initiation (early group; N = 408), or initiation when CD4 T cell count was less than or equal 200 cells/mm3 or with the development of an AIDS-defining condition (delayed group; N = 408). Every 3 months, all participants underwent an oral examination. The incidence of oral lesions was 4.10 in the early group and 17.85 in the delayed group (p-value
Diagnosis of HIV-Associated Oral Lesions in Relation to Early versus Delayed Antiretroviral Therapy: Results from the CIPRA HT001 Trial Ashita S. Batavia1*, Rode Secours2, Patrice Espinosa3, Marc Antoine Jean Juste2, Patrice Severe2, Jean William Pape1,2, Daniel W. Fitzgerald1 1 Weill Cornell Medical Center, New York, New York, United States of America, 2 Groupe Haitien d’Etude du Sarcome de Kaposi et des Infections Opportunistes (GHESKIO), Port-au-Prince, Haiti, 3 University of California San Francisco School of Dentistry, San Francisco, California, United States of America * [email protected]
Abstract OPEN ACCESS Citation: Batavia AS, Secours R, Espinosa P, Jean Juste MA, Severe P, Pape JW, et al. (2016) Diagnosis of HIV-Associated Oral Lesions in Relation to Early versus Delayed Antiretroviral Therapy: Results from the CIPRA HT001 Trial. PLoS ONE 11 (3): e0150656. doi:10.1371/journal.pone.0150656 Editor: Graciela Andrei, Rega Institute for Medical Research, BELGIUM Received: July 10, 2015 Accepted: February 16, 2016 Published: March 1, 2016 Copyright: © 2016 Batavia et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information files.
Oral mucosal lesions that are associated with HIV infection can play an important role in guiding the decision to initiate antiretroviral therapy (ART). The incidence of these lesions relative to the timing of ART initiation has not been well characterized. A randomized controlled clinical trial was conducted at the GHESKIO Center in Port-au-Prince, Haiti between 2004 and 2009. 816 HIV-infected ART-naïve participants with CD4 T cell counts between 200 and 350 cells/mm3 were randomized to either immediate ART initiation (early group; N = 408), or initiation when CD4 T cell count was less than or equal 200 cells/mm3 or with the development of an AIDS-defining condition (delayed group; N = 408). Every 3 months, all participants underwent an oral examination. The incidence of oral lesions was 4.10 in the early group and 17.85 in the delayed group (p-value
