RESEARCH ARTICLE
Development of a Newborn Screening Program for Critical Congenital Heart Disease (CCHD) in Taipei Pei-Chen Tsao1,2,3,4☯‡, Yu-Shih Shiau5☯‡, Szu-Hui Chiang5, Hui-Chen Ho6, Yu-Ling Liu7, Yuan-Fang Chung7, Li-Ju Lin7, Ming-Ren Chen8, Jia-Kan Chang9, Wen-Jue Soong1,2, HsiuLian Lin7, Betau Hwang2,10,11*, Kwang-Jen Hsiao5,12*
a11111
OPEN ACCESS Citation: Tsao P-C, Shiau Y-S, Chiang S-H, Ho H-C, Liu Y-L, Chung Y-F, et al. (2016) Development of a Newborn Screening Program for Critical Congenital Heart Disease (CCHD) in Taipei. PLoS ONE 11(4): e0153407. doi:10.1371/journal.pone.0153407 Editor: Jen-Hsiang Chuang, Centers for Disease Control, TAIWAN Received: January 4, 2016 Accepted: March 29, 2016 Published: April 13, 2016 Copyright: © 2016 Tsao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper. Funding: This project was partially funded by the United Way of Taiwan. Competing Interests: The authors have declared that no competing interests exist. Abbreviations: CCHD, Critical congenital heart disease; HLHS, hypoplastic left heart syndrome; PS, pulmonary atresia; TOF, tetralogy of Fallot; TAPVR, total anomalous pulmonary venous return; d-TGA, dtransposition of the great arteries; TA, tricuspid atresia; CoA, coarctation of the aorta; DORV, double-
1 Division of General Pediatrics, Pediatrics Department, Taipei Veterans General Hospital, Taipei, Taiwan, 2 Department of Pediatrics, School of Medicine, National Yang-Ming University, Taipei, Taiwan, 3 Institute of Physiology, School of Medicine, National Yang-Ming University, Taipei, Taiwan, 4 Institute of Emergency and Critical Care Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan, 5 Preventive Medicine Foundation, Taipei, Taiwan, 6 Taipei Institute of Pathology, Taipei, Taiwan, 7 Department of Health, Taipei City Government, Taipei, Taiwan, 8 MacKay Children’s Hospital, Taipei, Taiwan, 9 Pediatrics Department, Cheng Hsin General Hospital, Taipei, Taiwan, 10 Taipei City Hospital, Zhongxiao Branch, Taipei, Taiwan, 11 Cardiac Medical Center, Tung’s Taichung Metroharbor Hospital, Taichung, Taiwan, 12 Department of Education and Research, Taipei City Hospital, Taipei, Taiwan ☯ These authors contributed equally to this work. ‡ These authors are co-first authors on this work. * [email protected] (KJH); [email protected] (BH)
Abstract Background Early detection of critical congenital heart disease (CCHD) can significantly reduce morbidity and mortality among newborns. We investigate the feasibility of implementing a community-based newborn CCHD screening program in Taipei.
Methods Twelve birthing facilities in Taipei participated in a trial screening program between October 1, 2013, and March 31, 2014. Newborns underwent pulse oximetry at 24–36 h old, with probes attached to the right hand and one lower limb. Any screening saturation 95% in either extremity, with an absolute difference of 3% between the right hand and foot, was accepted as a screening pass. A screening result was considered as a fail if the oxygen saturation was
Development of a Newborn Screening Program for Critical Congenital Heart Disease (CCHD) in Taipei Pei-Chen Tsao1,2,3,4☯‡, Yu-Shih Shiau5☯‡, Szu-Hui Chiang5, Hui-Chen Ho6, Yu-Ling Liu7, Yuan-Fang Chung7, Li-Ju Lin7, Ming-Ren Chen8, Jia-Kan Chang9, Wen-Jue Soong1,2, HsiuLian Lin7, Betau Hwang2,10,11*, Kwang-Jen Hsiao5,12*
a11111
OPEN ACCESS Citation: Tsao P-C, Shiau Y-S, Chiang S-H, Ho H-C, Liu Y-L, Chung Y-F, et al. (2016) Development of a Newborn Screening Program for Critical Congenital Heart Disease (CCHD) in Taipei. PLoS ONE 11(4): e0153407. doi:10.1371/journal.pone.0153407 Editor: Jen-Hsiang Chuang, Centers for Disease Control, TAIWAN Received: January 4, 2016 Accepted: March 29, 2016 Published: April 13, 2016 Copyright: © 2016 Tsao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper. Funding: This project was partially funded by the United Way of Taiwan. Competing Interests: The authors have declared that no competing interests exist. Abbreviations: CCHD, Critical congenital heart disease; HLHS, hypoplastic left heart syndrome; PS, pulmonary atresia; TOF, tetralogy of Fallot; TAPVR, total anomalous pulmonary venous return; d-TGA, dtransposition of the great arteries; TA, tricuspid atresia; CoA, coarctation of the aorta; DORV, double-
1 Division of General Pediatrics, Pediatrics Department, Taipei Veterans General Hospital, Taipei, Taiwan, 2 Department of Pediatrics, School of Medicine, National Yang-Ming University, Taipei, Taiwan, 3 Institute of Physiology, School of Medicine, National Yang-Ming University, Taipei, Taiwan, 4 Institute of Emergency and Critical Care Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan, 5 Preventive Medicine Foundation, Taipei, Taiwan, 6 Taipei Institute of Pathology, Taipei, Taiwan, 7 Department of Health, Taipei City Government, Taipei, Taiwan, 8 MacKay Children’s Hospital, Taipei, Taiwan, 9 Pediatrics Department, Cheng Hsin General Hospital, Taipei, Taiwan, 10 Taipei City Hospital, Zhongxiao Branch, Taipei, Taiwan, 11 Cardiac Medical Center, Tung’s Taichung Metroharbor Hospital, Taichung, Taiwan, 12 Department of Education and Research, Taipei City Hospital, Taipei, Taiwan ☯ These authors contributed equally to this work. ‡ These authors are co-first authors on this work. * [email protected] (KJH); [email protected] (BH)
Abstract Background Early detection of critical congenital heart disease (CCHD) can significantly reduce morbidity and mortality among newborns. We investigate the feasibility of implementing a community-based newborn CCHD screening program in Taipei.
Methods Twelve birthing facilities in Taipei participated in a trial screening program between October 1, 2013, and March 31, 2014. Newborns underwent pulse oximetry at 24–36 h old, with probes attached to the right hand and one lower limb. Any screening saturation 95% in either extremity, with an absolute difference of 3% between the right hand and foot, was accepted as a screening pass. A screening result was considered as a fail if the oxygen saturation was
