Determination of Location, Size, and Transmurality of Chronic Myocardial Infarction Without Exogenous Contrast Media by Using Cardiac Magnetic Resonance Imaging at 3 T Avinash Kali, Ivan Cokic, Richard L.Q. Tang, Hsin-Jung Yang, Behzad Sharif, Eduardo Marbán, Debiao Li, Daniel S. Berman and Rohan Dharmakumar Circ Cardiovasc Imaging. 2014;7:471-481; originally published online March 28, 2014; doi: 10.1161/CIRCIMAGING.113.001541 Circulation: Cardiovascular Imaging is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Copyright © 2014 American Heart Association, Inc. All rights reserved. Print ISSN: 1941-9651. Online ISSN: 1942-0080
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Data Supplement (unedited) at: http://circimaging.ahajournals.org/circcvim/suppl/2014/03/28/CIRCIMAGING.113.001541.DC1.html
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Coronary Artery Disease Determination of Location, Size, and Transmurality of Chronic Myocardial Infarction Without Exogenous Contrast Media by Using Cardiac Magnetic Resonance Imaging at 3 T Avinash Kali, MS; Ivan Cokic, MD; Richard L.Q. Tang, MD; Hsin-Jung Yang, MS; Behzad Sharif, PhD; Eduardo Marbán, MD, PhD; Debiao Li, PhD; Daniel S. Berman, MD; Rohan Dharmakumar, PhD Background—Late-gadolinium–enhanced (LGE) cardiac MRI (CMR) is a powerful method for characterizing myocardial infarction (MI), but the requisite gadolinium infusion is estimated to be contraindicated in ≈20% of patients with MI because of end-stage chronic kidney disease. The purpose of this study is to investigate whether T1 CMR obtained without contrast agents at 3 T could be an alternative to LGE CMR for characterizing chronic MIs using a canine model of MI. Methods and Results—Canines (n=29) underwent CMR at 7 days (acute MI [AMI]) and 4 months (chronic MI [CMI]) after MI. Infarct location, size, and transmurality measured by using native T1 maps and LGE images at 1.5 T and 3 T were compared. Resolution of edema between AMI and CMI was examined with T2 maps. T1 maps overestimated infarct size and transmurality relative to LGE images in AMI (P=0.016 and P=0.007, respectively), which was not observed in CMI (P=0.49 and P=0.81, respectively) at 3 T. T1 maps underestimated infarct size and transmurality relative to LGE images in AMI and CMI (P
The online version of this article, along with updated information and services, is located on the World Wide Web at: http://circimaging.ahajournals.org/content/7/3/471
Data Supplement (unedited) at: http://circimaging.ahajournals.org/circcvim/suppl/2014/03/28/CIRCIMAGING.113.001541.DC1.html
Permissions: Requests for permissions to reproduce figures, tables, or portions of articles originally published in Circulation: Cardiovascular Imaging can be obtained via RightsLink, a service of the Copyright Clearance Center, not the Editorial Office. Once the online version of the published article for which permission is being requested is located, click Request Permissions in the middle column of the Web page under Services. Further information about this process is available in the Permissions and Rights Question and Answer document. Reprints: Information about reprints can be found online at: http://www.lww.com/reprints Subscriptions: Information about subscribing to Circulation: Cardiovascular Imaging is online at: http://circimaging.ahajournals.org//subscriptions/
Downloaded from http://circimaging.ahajournals.org/ at Universitaet Zuerich on July 11, 2014
Coronary Artery Disease Determination of Location, Size, and Transmurality of Chronic Myocardial Infarction Without Exogenous Contrast Media by Using Cardiac Magnetic Resonance Imaging at 3 T Avinash Kali, MS; Ivan Cokic, MD; Richard L.Q. Tang, MD; Hsin-Jung Yang, MS; Behzad Sharif, PhD; Eduardo Marbán, MD, PhD; Debiao Li, PhD; Daniel S. Berman, MD; Rohan Dharmakumar, PhD Background—Late-gadolinium–enhanced (LGE) cardiac MRI (CMR) is a powerful method for characterizing myocardial infarction (MI), but the requisite gadolinium infusion is estimated to be contraindicated in ≈20% of patients with MI because of end-stage chronic kidney disease. The purpose of this study is to investigate whether T1 CMR obtained without contrast agents at 3 T could be an alternative to LGE CMR for characterizing chronic MIs using a canine model of MI. Methods and Results—Canines (n=29) underwent CMR at 7 days (acute MI [AMI]) and 4 months (chronic MI [CMI]) after MI. Infarct location, size, and transmurality measured by using native T1 maps and LGE images at 1.5 T and 3 T were compared. Resolution of edema between AMI and CMI was examined with T2 maps. T1 maps overestimated infarct size and transmurality relative to LGE images in AMI (P=0.016 and P=0.007, respectively), which was not observed in CMI (P=0.49 and P=0.81, respectively) at 3 T. T1 maps underestimated infarct size and transmurality relative to LGE images in AMI and CMI (P
