HHS Public Access Author manuscript Author Manuscript
Cancer Epidemiol Biomarkers Prev. Author manuscript; available in PMC 2017 February 01. Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2016 February ; 25(2): 381–390. doi: 10.1158/1055-9965.EPI-15-0718.
Determinants and consequences of arsenic metabolism efficiency among 4,794 individuals: demographics, lifestyle, genetics, and toxicity
Author Manuscript
Rick J. Jansen1, Maria Argos2, Lin Tong1, Jiabei Li1, Muhammad Rakibuz-Zaman, Md3, Tariqul Islam3, Vesna Slavkovich4, Alauddin Ahmed3, Ana Navas-Acien5, Faruque Parvez4, Yu Chen6, Mary V. Gamble4, Joseph H. Graziano4, Brandon L. Pierce1,7,*, and Habibul Ahsan1,7,8,* 1Department
of Public Health Sciences, The University of Chicago, Chicago, Illinois, USA
2Divison
of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, Illinois, USA
3UChicago
Research Bangladesh, Dhaka, Bangladesh
4Department
of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA 5
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Author Manuscript
6Departments
of Population Health and Environmental Medicine, New York University School of Medicine, New York, NY, USA
7Department
of Human Genetics and Comprehensive Cancer Center, The University of Chicago, Chicago, Illinois, USA 8Department
of Medicine, The University of Chicago, Chicago, Illinois, USA
Abstract
Author Manuscript
Background—Exposure to inorganic arsenic (iAs), class I carcinogen, affects several hundredmillion people worldwide. Once absorbed, iAs is converted to monomethylated (MMA) and then dimethylated forms (DMA), with methylation facilitating urinary excretion. The abundance of each species in urine relative to their sum (iAs%, MMA%, and DMA%), varies across individuals, reflecting differences in arsenic metabolism capacity. Methods—The association of arsenic metabolism phenotypes with participant characteristics and arsenical skin lesions was characterized among 4,794 participants in the Health Effects of Arsenic Longitudinal Study (Araihazar, Bangladesh). Metabolism phenotypes include those obtained from principal components (PC) analysis of arsenic species.
*
corresponding authors: Brandon Pierce, Department of Public Health Sciences, University of Chicago, 5841 S. Maryland Ave., W264, MC2000, Chicago, IL 60637; phone: 773-702-1917; fax: 773-734-0139 ; [email protected], Habibul Ahsan, Department of Public Health Sciences, The University of Chicago Biological Sciences, 5841 S. Maryland Ave., Suite N102, Chicago, IL 60637; phone: 773- 834-9956; fax: 773-834-9956; [email protected]. The authors have no competing financial interests to declare.
Jansen et al.
Page 2
Author Manuscript
Results—Two independent PCs were identified: PC1 appears to represent capacity to produce DMA (2nd methylation step), and PC2 appears to represent capacity to convert iAs to MMA (1st methylation step). PC 1 was positively associated (p
Cancer Epidemiol Biomarkers Prev. Author manuscript; available in PMC 2017 February 01. Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2016 February ; 25(2): 381–390. doi: 10.1158/1055-9965.EPI-15-0718.
Determinants and consequences of arsenic metabolism efficiency among 4,794 individuals: demographics, lifestyle, genetics, and toxicity
Author Manuscript
Rick J. Jansen1, Maria Argos2, Lin Tong1, Jiabei Li1, Muhammad Rakibuz-Zaman, Md3, Tariqul Islam3, Vesna Slavkovich4, Alauddin Ahmed3, Ana Navas-Acien5, Faruque Parvez4, Yu Chen6, Mary V. Gamble4, Joseph H. Graziano4, Brandon L. Pierce1,7,*, and Habibul Ahsan1,7,8,* 1Department
of Public Health Sciences, The University of Chicago, Chicago, Illinois, USA
2Divison
of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, Illinois, USA
3UChicago
Research Bangladesh, Dhaka, Bangladesh
4Department
of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA 5
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Author Manuscript
6Departments
of Population Health and Environmental Medicine, New York University School of Medicine, New York, NY, USA
7Department
of Human Genetics and Comprehensive Cancer Center, The University of Chicago, Chicago, Illinois, USA 8Department
of Medicine, The University of Chicago, Chicago, Illinois, USA
Abstract
Author Manuscript
Background—Exposure to inorganic arsenic (iAs), class I carcinogen, affects several hundredmillion people worldwide. Once absorbed, iAs is converted to monomethylated (MMA) and then dimethylated forms (DMA), with methylation facilitating urinary excretion. The abundance of each species in urine relative to their sum (iAs%, MMA%, and DMA%), varies across individuals, reflecting differences in arsenic metabolism capacity. Methods—The association of arsenic metabolism phenotypes with participant characteristics and arsenical skin lesions was characterized among 4,794 participants in the Health Effects of Arsenic Longitudinal Study (Araihazar, Bangladesh). Metabolism phenotypes include those obtained from principal components (PC) analysis of arsenic species.
*
corresponding authors: Brandon Pierce, Department of Public Health Sciences, University of Chicago, 5841 S. Maryland Ave., W264, MC2000, Chicago, IL 60637; phone: 773-702-1917; fax: 773-734-0139 ; [email protected], Habibul Ahsan, Department of Public Health Sciences, The University of Chicago Biological Sciences, 5841 S. Maryland Ave., Suite N102, Chicago, IL 60637; phone: 773- 834-9956; fax: 773-834-9956; [email protected]. The authors have no competing financial interests to declare.
Jansen et al.
Page 2
Author Manuscript
Results—Two independent PCs were identified: PC1 appears to represent capacity to produce DMA (2nd methylation step), and PC2 appears to represent capacity to convert iAs to MMA (1st methylation step). PC 1 was positively associated (p
