Epidemiological evidence strongly suggests that circulatory levels of 25-hydroxyvitamin D below 50 nmol/l are associated with cognitive impairment and the development of dementia. A number of biochemical mechanisms could explain these effects; however, interventional studies to date have revealed disappointingly little. Morley, J. E. Nat. Rev. Neurol. advance online publication 21 October 2014; doi:10.1038/nrneurol.2014.193
effect on cognition.4 This failure might be related to a number of factors. Most importantly, it seems that only persons with low 25-hydroxyvitamin D levels (