Downloaded from http://fn.bmj.com/ on February 7, 2016 - Published by group.bmj.com
ADC-FNN Online First, published on February 2, 2016 as 10.1136/archdischild-2015-308728 Original article
Delivery room management of extremely preterm infants: the EPIPAGE-2 study J Perlbarg,1 P Y Ancel,1,2 B Khoshnood,1 M Durox,1 P Boileau,3,4 M Garel,1 M Kaminski,1 F Goffinet,1,5 L Foix-L’Hélias,1,6 the Epipage-2 Ethics group 1
Obstetrical Perinatal and Pediatric Epidemiology Team, Epidemiology and Biostatistics Sorbonne Paris Cité Research Center (U1153), INSERM, Paris, France 2 URC-CIC P1419, DHU Risk in Pregnancy, Cochin Hôtel-Dieu Hospital, APHP, Paris, France 3 Neonatal Intensive Care Unit, CHI Poissy Saint-Germain-enLaye, Poissy, France 4 EA 7285, Versailles SaintQuentin-en-Yvelines University, Versailles, France 5 Maternité Port-Royal, ParisDescartes University, Cochin Broca Hôtel-Dieu Hospital, Assistance Publique-Hôpitaux de Paris, DHU Risk in Pregnancy, Paris, France 6 Service de Néonatologie, Hôpital Armand Trousseau, Assistance Publique-Hôpitaux de Paris, Pierre et Marie Curie University, Paris, France Correspondence to Julie Perlbarg, Obstetrical, Perinatal and Pediatric Epidemiology Team, Epidemiology and Statistics, Sorbonne Paris Cité Research Center (U1153), Inserm, 4, rue de la Chine, 75020 Paris, France; [email protected] Received 4 April 2015 Revised 15 December 2015 Accepted 6 January 2016
ABSTRACT Objective To analyse the delivery room management of babies born between 22 and 26 weeks of completed gestational age and to identify the factors associated with the withholding or withdrawal of intensive care. Study design Population-based cohort study. Patients and methods Our study population comprised 2145 births between 22 and 26 completed weeks enrolled in the EPIPAGE-2 study, a French cohort of very preterm infants born in 2011. The primary outcome measure was withholding or withdrawal of intensive care in the delivery room. Results Among infants born alive at 22–23 weeks, intensive care was withheld or withdrawn for >90%. At 24 weeks, resuscitative measures were withheld or withdrawn for 38%, at 25 weeks for 8% and at 26 weeks for 3%. Other factors besides gestational age at birth associated with this withholding or withdrawal for infants born at 24–26 weeks were birth weight
ADC-FNN Online First, published on February 2, 2016 as 10.1136/archdischild-2015-308728 Original article
Delivery room management of extremely preterm infants: the EPIPAGE-2 study J Perlbarg,1 P Y Ancel,1,2 B Khoshnood,1 M Durox,1 P Boileau,3,4 M Garel,1 M Kaminski,1 F Goffinet,1,5 L Foix-L’Hélias,1,6 the Epipage-2 Ethics group 1
Obstetrical Perinatal and Pediatric Epidemiology Team, Epidemiology and Biostatistics Sorbonne Paris Cité Research Center (U1153), INSERM, Paris, France 2 URC-CIC P1419, DHU Risk in Pregnancy, Cochin Hôtel-Dieu Hospital, APHP, Paris, France 3 Neonatal Intensive Care Unit, CHI Poissy Saint-Germain-enLaye, Poissy, France 4 EA 7285, Versailles SaintQuentin-en-Yvelines University, Versailles, France 5 Maternité Port-Royal, ParisDescartes University, Cochin Broca Hôtel-Dieu Hospital, Assistance Publique-Hôpitaux de Paris, DHU Risk in Pregnancy, Paris, France 6 Service de Néonatologie, Hôpital Armand Trousseau, Assistance Publique-Hôpitaux de Paris, Pierre et Marie Curie University, Paris, France Correspondence to Julie Perlbarg, Obstetrical, Perinatal and Pediatric Epidemiology Team, Epidemiology and Statistics, Sorbonne Paris Cité Research Center (U1153), Inserm, 4, rue de la Chine, 75020 Paris, France; [email protected] Received 4 April 2015 Revised 15 December 2015 Accepted 6 January 2016
ABSTRACT Objective To analyse the delivery room management of babies born between 22 and 26 weeks of completed gestational age and to identify the factors associated with the withholding or withdrawal of intensive care. Study design Population-based cohort study. Patients and methods Our study population comprised 2145 births between 22 and 26 completed weeks enrolled in the EPIPAGE-2 study, a French cohort of very preterm infants born in 2011. The primary outcome measure was withholding or withdrawal of intensive care in the delivery room. Results Among infants born alive at 22–23 weeks, intensive care was withheld or withdrawn for >90%. At 24 weeks, resuscitative measures were withheld or withdrawn for 38%, at 25 weeks for 8% and at 26 weeks for 3%. Other factors besides gestational age at birth associated with this withholding or withdrawal for infants born at 24–26 weeks were birth weight
