Psychopharmacology (2015) 232:165–172 DOI 10.1007/s00213-014-3650-y
ORIGINAL INVESTIGATION
Decreased serum TNF-alpha levels in chronic schizophrenia patients on long-term antipsychotics: correlation with psychopathology and cognition Meng Han Lv & Yun Long Tan & Shao Xiao Yan & Li Tian & Da Chun Chen & Shu Ping Tan & Zhi Ren Wang & Fu De Yang & Jin H. Yoon & Giovana B. Zunta-Soares & Jair C. Soares & Xiang Yang Zhang
Received: 30 March 2014 / Accepted: 30 May 2014 / Published online: 24 June 2014 # Springer-Verlag Berlin Heidelberg 2014
Abstract Objective A substantial body of evidence implicates TNFalpha (TNFα) and TNFα-related signaling pathways in the pathophysiology of schizophrenia. The current study examined the relationship between TNFα serum levels and both psychopathological as well as cognitive symptoms in schizophrenia. Materials and methods Serum TNFα levels were assessed in 89 patients diagnosed with schizophrenia and compared to 43 healthy control subjects matched for age and gender. Schizophrenic symptomatology was assessed with the Positive and Negative Syndrome Scale (PANSS), and serum TNFα levels were measured by sandwich enzyme-linked immunosorbent assay (ELISA). Results TNFα levels were significantly lower in patients with chronic schizophrenia relative to healthy control subjects (p
ORIGINAL INVESTIGATION
Decreased serum TNF-alpha levels in chronic schizophrenia patients on long-term antipsychotics: correlation with psychopathology and cognition Meng Han Lv & Yun Long Tan & Shao Xiao Yan & Li Tian & Da Chun Chen & Shu Ping Tan & Zhi Ren Wang & Fu De Yang & Jin H. Yoon & Giovana B. Zunta-Soares & Jair C. Soares & Xiang Yang Zhang
Received: 30 March 2014 / Accepted: 30 May 2014 / Published online: 24 June 2014 # Springer-Verlag Berlin Heidelberg 2014
Abstract Objective A substantial body of evidence implicates TNFalpha (TNFα) and TNFα-related signaling pathways in the pathophysiology of schizophrenia. The current study examined the relationship between TNFα serum levels and both psychopathological as well as cognitive symptoms in schizophrenia. Materials and methods Serum TNFα levels were assessed in 89 patients diagnosed with schizophrenia and compared to 43 healthy control subjects matched for age and gender. Schizophrenic symptomatology was assessed with the Positive and Negative Syndrome Scale (PANSS), and serum TNFα levels were measured by sandwich enzyme-linked immunosorbent assay (ELISA). Results TNFα levels were significantly lower in patients with chronic schizophrenia relative to healthy control subjects (p
