Decreased Bone Mineral Density at the Femoral Neck and Lumbar Spine in South Indian Patients with Type 2 Diabetes
Internal Medicine Section
DOI: 10.7860/JCDR/2015/14390.6450
Original Article
Pratheesh George Mathen1, Molly Mary Thabah2, Bobby Zachariah3, Ashok Kumar Das4
ABSTRACT Background: With prevalence of diabetes in India reaching epidemic proportions and increase in the population of geriatric age group and risks of falls, it is important to understand the effect that diabetes has on bone health. Aim: The objective was to assess bone mineral density (BMD) of patients with type 2 diabetes mellitus (T2DM) and to study factors contributing to BMD in patients with T2DM. Materials and Methods: This was a prospective crosssectional study on 150 patients with T2DM (diagnosed at age > 30 years) and an equal number (n=150) of age and sex matched healthy controls from September 2012 to July 2014 at a tertiary care center located in Southern India. BMD was measured at the femoral neck and lumbar spine (L2–L4) by dual energy absorptiometry (DXA) in cases and controls. Serum total calcium, phosphorus and alkaline phosphatase (ALP) and 25OH- vitamin D3 was measured in patient group. Results: Mean age (SD) was 51.29 (±8.05) and 51 (±8.3) years in
cases and controls, respectively. The femoral neck and lumbar spine BMD was significantly lower in T2DM cases compared to controls. Also the femoral neck and lumbar spine T-score was significantly lower in T2DM cases compared to controls. Femoral neck BMD among male patients with T2DM was significantly lower compared to controls (men). Among women, BMD at femoral neck as well as lumbar spine was significantly lower in cases when compared to controls. Ninety six out of 150 (64%) T2DM cases had Vitamin D values 30 years and above) and an equal number (n=150) of age and sex matched healthy controls from September 2012 to July 2014, at a tertiary care center located in South India. The sample size was calculated to be 150 cases and 150 controls in order to detect a change in BMD by at least 0.2 g/ cm2 with 80% power and alpha error of 5%. The diagnosis of T2DM was based on the criteria of the American Diabetes Association 2012 [4]. 8
Patients with type 1 diabetes, those with chronic kidney disease (with calculated eGFR of
Internal Medicine Section
DOI: 10.7860/JCDR/2015/14390.6450
Original Article
Pratheesh George Mathen1, Molly Mary Thabah2, Bobby Zachariah3, Ashok Kumar Das4
ABSTRACT Background: With prevalence of diabetes in India reaching epidemic proportions and increase in the population of geriatric age group and risks of falls, it is important to understand the effect that diabetes has on bone health. Aim: The objective was to assess bone mineral density (BMD) of patients with type 2 diabetes mellitus (T2DM) and to study factors contributing to BMD in patients with T2DM. Materials and Methods: This was a prospective crosssectional study on 150 patients with T2DM (diagnosed at age > 30 years) and an equal number (n=150) of age and sex matched healthy controls from September 2012 to July 2014 at a tertiary care center located in Southern India. BMD was measured at the femoral neck and lumbar spine (L2–L4) by dual energy absorptiometry (DXA) in cases and controls. Serum total calcium, phosphorus and alkaline phosphatase (ALP) and 25OH- vitamin D3 was measured in patient group. Results: Mean age (SD) was 51.29 (±8.05) and 51 (±8.3) years in
cases and controls, respectively. The femoral neck and lumbar spine BMD was significantly lower in T2DM cases compared to controls. Also the femoral neck and lumbar spine T-score was significantly lower in T2DM cases compared to controls. Femoral neck BMD among male patients with T2DM was significantly lower compared to controls (men). Among women, BMD at femoral neck as well as lumbar spine was significantly lower in cases when compared to controls. Ninety six out of 150 (64%) T2DM cases had Vitamin D values 30 years and above) and an equal number (n=150) of age and sex matched healthy controls from September 2012 to July 2014, at a tertiary care center located in South India. The sample size was calculated to be 150 cases and 150 controls in order to detect a change in BMD by at least 0.2 g/ cm2 with 80% power and alpha error of 5%. The diagnosis of T2DM was based on the criteria of the American Diabetes Association 2012 [4]. 8
Patients with type 1 diabetes, those with chronic kidney disease (with calculated eGFR of
