191

Toxicology L..etrers, 52 (1990) 191-199

Elsevier

TOXLET 002353

Damage to red blood cells by halocompounds

Francisco J. Hidalgo, Rosario Zamora and Al L. Tappel Department

of Food Science and Technology,

University of California, Davis, CA (U.S.A.)

(Received 22 September 1989) (Accepted 26 February 1990) Key words: Damage to red blood cells; Oxidative stress; Halocompound toxicity; LDSo

SUMMARY Twenty-five halocompounds were screened as inducers of hemoglobin degradation and lipid peroxidation in rat red blood cells (RBC). RBC activated halocompounds, and oxyhemoglobin remaining depended on the halocompounds employed. Thiobarbituric-acid-reactive substances (TBARS), an index of lipid peroxidation, also depended on the halocompound. TBARS were inversely correlated and oxyhemoglobin percentage was directly correlated with the logarithm of oral LD5,, of the halocompounds (r=0.79, P

Damage to red blood cells by halocompounds.

Twenty-five halocompounds were screened as inducers of hemoglobin degradation and lipid peroxidation in rat red blood cells (RBC). RBC activated haloc...
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