HHS Public Access Author manuscript Author Manuscript
Early Hum Dev. Author manuscript; available in PMC 2017 May 01. Published in final edited form as: Early Hum Dev. 2016 May ; 96: 27–30. doi:10.1016/j.earlhumdev.2016.03.003.
Daily mortality of infants born at less than 30 weeks’ gestation Christoph P. Hornik, MD, MPHa,b, Ashley L. Sherwood, MD, MMCia,b, C. Michael Cotten, MD, MHSa, Matthew M. Laughon, MD, MPHc, Reese H. Clark, MDd, and P. Brian Smith, MD, MPH, MHSa,b aDepartment bDuke
of Pediatrics, Duke University School of Medicine, Durham, NC, United States
Clinical Research Institute, Duke University School of Medicine, Durham, NC, United
Author Manuscript
States cDepartment
of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United
States dPediatrix-Obstetrix
Center for Research and Education, Sunrise, FL, United States
Abstract Background—Few studies have reported odds of mortality for hospitalized premature infants stratified by postnatal age and adjusted for severity of illness. Our objective was to examine dayby-day mortality of premature infants in a large multicenter cohort of infants, adjusted for demographics, severity of illness, and receipt of therapeutic interventions.
Author Manuscript
Methods—This was a multicenter cohort study of infants cared for in 362 neonatal intensive care units with a shared clinical data warehouse from 1997 to 2013. We included all inborn infants born at 22–29 weeks’ gestational age with available mortality discharge data. We report the point prevalence of survival to hospital discharge stratified by gestational and postnatal age. Results—We identified 64,896 infants, of whom 55,348 (85%) survived to hospital discharge. Survival increased with gestational and postnatal age, until infants reach a postmenstrual age of approximately 37 weeks, after which survival began to decrease. Overall survival increased over time (80% in 1997 to 88% in 2013, P99)
14,595/14,674 (99)
15,220/15,439 (99)
14,990/15,363 (98)
29 n=15,689
Author Manuscript
Point prevalence of survival by gestational and postnatal age (DOL).
.15
Early Hum Dev. Author manuscript; available in PMC 2017 May 01. Published in final edited form as: Early Hum Dev. 2016 May ; 96: 27–30. doi:10.1016/j.earlhumdev.2016.03.003.
Daily mortality of infants born at less than 30 weeks’ gestation Christoph P. Hornik, MD, MPHa,b, Ashley L. Sherwood, MD, MMCia,b, C. Michael Cotten, MD, MHSa, Matthew M. Laughon, MD, MPHc, Reese H. Clark, MDd, and P. Brian Smith, MD, MPH, MHSa,b aDepartment bDuke
of Pediatrics, Duke University School of Medicine, Durham, NC, United States
Clinical Research Institute, Duke University School of Medicine, Durham, NC, United
Author Manuscript
States cDepartment
of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United
States dPediatrix-Obstetrix
Center for Research and Education, Sunrise, FL, United States
Abstract Background—Few studies have reported odds of mortality for hospitalized premature infants stratified by postnatal age and adjusted for severity of illness. Our objective was to examine dayby-day mortality of premature infants in a large multicenter cohort of infants, adjusted for demographics, severity of illness, and receipt of therapeutic interventions.
Author Manuscript
Methods—This was a multicenter cohort study of infants cared for in 362 neonatal intensive care units with a shared clinical data warehouse from 1997 to 2013. We included all inborn infants born at 22–29 weeks’ gestational age with available mortality discharge data. We report the point prevalence of survival to hospital discharge stratified by gestational and postnatal age. Results—We identified 64,896 infants, of whom 55,348 (85%) survived to hospital discharge. Survival increased with gestational and postnatal age, until infants reach a postmenstrual age of approximately 37 weeks, after which survival began to decrease. Overall survival increased over time (80% in 1997 to 88% in 2013, P99)
14,595/14,674 (99)
15,220/15,439 (99)
14,990/15,363 (98)
29 n=15,689
Author Manuscript
Point prevalence of survival by gestational and postnatal age (DOL).
.15
