Scand.

J. Immunol.

3 6 , S u p p l . I I . 161 1 6 6 . 1992

Cytokine Responses to Parasite Antigens: In Vitro Cytokine Production to Promastigotes of L. aethiopica by Cells from Non-Leishniania Exposed Donors may Influence Disease Establishment H. O. A K U F F O Department of ltifcctious Diseases. Karolinska Institute. Huddinge Hospital, Huddingc. Sweden

AkufTo HO. Cytokine Responses to Parasiic Antigens: In Vitro Cytokine Production to Promastigotes of L. aelhiopua by Cells from Non-U-i.shmania Exposed Donors may Influence Disease Establishment. Scand J rmmunol I9«>2;36{Suppl.l I):16I 6 The various cytokinv responses associated with stimulation by parasites is discussed with emphasis on Iwiilimania parasites. Cells from normal individuals can rcsptind lo Lei.shmania iinu^cn^ in vitro but the Slate of the antigen useil for stimulation influences the ouicomv. We have used ceils from min-l^-ishmania enposcd donors and stimulated them in vitro with variously treated promastigotes of L. aethiopica. The levels of some cytokines released into the supernatant were measured. All the ljri\hmania preparations tested induced high levels of IL-(>. whereas IFN-v production to the different stimuli was variable in the individual donors. The ahilit> of these supcmatants to inhibit in trace! lular forms of/., aeihiopica was someiimes stntnger in /.,

Cytokine responses to parasite antigens: in vitro cytokine production to promastigotes of L. aethiopica by cells from non-Leishmania exposed donors may influence disease establishment.

The various cytokine responses associated with stimulation by parasites is discussed with emphasis on Leishmania parasites. Cells from normal individu...
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