0021-972X/90/7104-1036$02.00/0 Journal of Clinical Endocrinology and Metabolism Copyright © 1990 by The Endocrine Society

Vol. 71, No. 4 Printed in U.S.A.

Cytochrome P450IIE1 Is Elevated in Lymphocytes from Poorly Controlled Insulin-Dependent Diabetics* BYOUNG J. SONG, RICHARD L. VEECH, AND PAUL SAENGER Laboratory of Metabolism and Molecular Biology, National Institute of Alcohol Abuse and Alcoholism (B.J.S., R.L. V.), Rockville, Maryland 20852; and the Department of Pediatrics, Montefiore Medical Center, Albert Einstein College of Medicine (P.S.), Bronx, New York 10467

ABSTRACT. Cytochrome P450IIE1, a member of the cytochrome P450 supergene family, was measured in peripheral lymphocytes of 14 patients with insulin-dependent diabetes mellitus who were in poor metabolic control, as evidenced by elevated hemoglobin Ai levels (mean, 11.9 ± 2.8%; normal,

Cytochrome P450IIE1 is elevated in lymphocytes from poorly controlled insulin-dependent diabetics.

Cytochrome P450IIE1, a member of the cytochrome P450 supergene family, was measured in peripheral lymphocytes of 14 patients with insulin-dependent di...
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