Pharmac. Ther.VoL 52, pp. 269-286, 1991 Printed in Great Britain. All rights reserved
0163-7258/91 $0.00 + 0.50 © 1992 Pergamon Press Ltd
Associate Editor: D. SHUGAR
CURRENT PROGRESS ON NUCLEOSIDE ANTIBIOTICS KIYOSHI ISONO* Antibiotics Laboratory, RIKEN, The Institute of Physical and Chemical Research, Wako-shi, Saitama-ken, 351-01, Japan Abstract--Structure and biological activity of thirty-six new nucleoside antibotics which appeared after the 1988 review are described. New synthetic analogs of neplanocin and oxetanocin are also described with special emphasis on their antiviral activities. New biosynthetic findings on nikkomycins, blasticidin S, and griseolic acid are also reviewed.
CONTENTS 1. Introduction 2. Base Analogs 2.1. Guanine 7-N-oxide 2.2. Echiguanines 3. Adenosine Analogs 3.1. Neplanocin A analogs and aristeromycin 3.2. Oxetanocin and analogs 3.3. Toyocamycin and sangivamycin 3.4. Cadeguomycin 3.5. Mycalisines 4. Guanosine Analogs 4.1. 6-Thioguanosine 5. Uridine Analogs 5.1. 5-Formyloxymethyluridine 5.2. 3-Methylpseudouridine 5.3. 4-Thiouridine 6. C-Nucleosides 6.1. Pyrrolosine 6.2. Hydantocidin 7. Indole Nucleosides 7.1. Neosidomycin and SF-2140 8. Y-Amino-Y-deoxyadenosine 8.1. Antibiotic FR-900403 9. 4'-Aminoacyl-4'-deoxypyranosyl Cytosines 9.1. Blasticidin S and mildiomycin 9.2. 5-Hydroxymethyllencylblasticidin S and 5-hydroxymethylblasticidin S 10. Glycosyl Nucleosides 10.1. 5'-O
0163-7258/91 $0.00 + 0.50 © 1992 Pergamon Press Ltd
Associate Editor: D. SHUGAR
CURRENT PROGRESS ON NUCLEOSIDE ANTIBIOTICS KIYOSHI ISONO* Antibiotics Laboratory, RIKEN, The Institute of Physical and Chemical Research, Wako-shi, Saitama-ken, 351-01, Japan Abstract--Structure and biological activity of thirty-six new nucleoside antibotics which appeared after the 1988 review are described. New synthetic analogs of neplanocin and oxetanocin are also described with special emphasis on their antiviral activities. New biosynthetic findings on nikkomycins, blasticidin S, and griseolic acid are also reviewed.
CONTENTS 1. Introduction 2. Base Analogs 2.1. Guanine 7-N-oxide 2.2. Echiguanines 3. Adenosine Analogs 3.1. Neplanocin A analogs and aristeromycin 3.2. Oxetanocin and analogs 3.3. Toyocamycin and sangivamycin 3.4. Cadeguomycin 3.5. Mycalisines 4. Guanosine Analogs 4.1. 6-Thioguanosine 5. Uridine Analogs 5.1. 5-Formyloxymethyluridine 5.2. 3-Methylpseudouridine 5.3. 4-Thiouridine 6. C-Nucleosides 6.1. Pyrrolosine 6.2. Hydantocidin 7. Indole Nucleosides 7.1. Neosidomycin and SF-2140 8. Y-Amino-Y-deoxyadenosine 8.1. Antibiotic FR-900403 9. 4'-Aminoacyl-4'-deoxypyranosyl Cytosines 9.1. Blasticidin S and mildiomycin 9.2. 5-Hydroxymethyllencylblasticidin S and 5-hydroxymethylblasticidin S 10. Glycosyl Nucleosides 10.1. 5'-O
