Thieme
Original Article
Curcumin Protects Mitochondria and Cardiomyocytes from Oxidative Damage and Apoptosis Induced by Hemiscorpius Lepturus Venom
Affiliations 1 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2 Department of Occupational Health Engineering, Research Center for Health, Safety and Environment (RCHSE), Alborz University of Medical Sciences, Karaj, Iran 3 Department of Pharmacology and Toxicology, School of Pharmacy, Ardabil University of Medical Science, Ardabil, Iran Key words hemiscorpius lepturus, isolated mitochondria, heart, curcumin received 08.07.2017 accepted 22.08.2017 Bibliography DOI https://doi.org/10.1055/s-0043-119073 Published online: 2017 | Drug Res © Georg Thieme Verlag KG Stuttgart · New York ISSN 2194-9379 Correspondence Jalal Pourahmad Prof. of Toxicology and Pharmacology Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences P.O. Box: 14155-6153 Tehran Iran Tel.: + 98/21/2255 8786, Fax: + 98/21/8820 9620 [email protected]
Introduction It reported that the H. lepturus scorpion is endemic in the southwestern province of Khuzestan and other parts of western Iran responsible for 10 % of the reported stings with high mortalities approximately 19.5 deaths among children each year, frequently in spring and summer [1–3]. Envenomation by Hemiscorpius Lepturus (H. lepturus) venom belongs to Hemiscorpiidae family, is not
Naserzadeh P et al. Curcumin Protects Cardiomyocytes … Drug Res
Ahmad Salimi Assistant Professor of Toxicology and Pharmacology School of Pharmacy, Ardabil University of Medical Science P.O. Box: 56189-53141 Ardabil Iran Tel.: + 98/45/3352 3833, Fax: + 98/45/3352 2197 [email protected] Abs tr ac t The main aim of the current study was to determine cardiotoxicity mechanisms of H. lepturus and protective effect of curcumin against this toxin in rats, using isolated heart mitochondria and cardiomyocytes. Our findings indicated that H. lepturus venom caused significantly ((P
Original Article
Curcumin Protects Mitochondria and Cardiomyocytes from Oxidative Damage and Apoptosis Induced by Hemiscorpius Lepturus Venom
Affiliations 1 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2 Department of Occupational Health Engineering, Research Center for Health, Safety and Environment (RCHSE), Alborz University of Medical Sciences, Karaj, Iran 3 Department of Pharmacology and Toxicology, School of Pharmacy, Ardabil University of Medical Science, Ardabil, Iran Key words hemiscorpius lepturus, isolated mitochondria, heart, curcumin received 08.07.2017 accepted 22.08.2017 Bibliography DOI https://doi.org/10.1055/s-0043-119073 Published online: 2017 | Drug Res © Georg Thieme Verlag KG Stuttgart · New York ISSN 2194-9379 Correspondence Jalal Pourahmad Prof. of Toxicology and Pharmacology Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences P.O. Box: 14155-6153 Tehran Iran Tel.: + 98/21/2255 8786, Fax: + 98/21/8820 9620 [email protected]
Introduction It reported that the H. lepturus scorpion is endemic in the southwestern province of Khuzestan and other parts of western Iran responsible for 10 % of the reported stings with high mortalities approximately 19.5 deaths among children each year, frequently in spring and summer [1–3]. Envenomation by Hemiscorpius Lepturus (H. lepturus) venom belongs to Hemiscorpiidae family, is not
Naserzadeh P et al. Curcumin Protects Cardiomyocytes … Drug Res
Ahmad Salimi Assistant Professor of Toxicology and Pharmacology School of Pharmacy, Ardabil University of Medical Science P.O. Box: 56189-53141 Ardabil Iran Tel.: + 98/45/3352 3833, Fax: + 98/45/3352 2197 [email protected] Abs tr ac t The main aim of the current study was to determine cardiotoxicity mechanisms of H. lepturus and protective effect of curcumin against this toxin in rats, using isolated heart mitochondria and cardiomyocytes. Our findings indicated that H. lepturus venom caused significantly ((P
