ONCOLOGY LETTERS 11: 3817-3820, 2016

CT findings of sclerosing stromal tumor of the ovary: A report of two cases and review of the literature TONGTONG TIAN, QINGQIANG ZHU, WENXIN CHEN, SHOUAN WANG, WEIFAN SUI and JINGTAO WU Department of Radiology, Subei People's Hospital of Jiangsu Province, Medical School of Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China Received January 16, 2015; Accepted February 16, 2016 DOI: 10.3892/ol.2016.4441 Abstract. Sclerosing stromal tumor (SST) of the ovary, which was first described by Chalvardjian and Scully in 1973, is a rare ovarian neoplasm, occurring predominantly in young women. The most common clinical symptom in patients with SST is menstrual irregularities. Microscopically, the tumor is characterized by the presence of pseudo‑lobulated cellular areas, with a prominent tendency to sclerosis, marked vascularity and pronounced variation in cellular size and shape. In the current study, 2 cases of SST of the ovary are presented. These cases were confirmed by imaging, surgical and histological examination. No adjuvant therapy was administered to the patients and the two patients were disease‑free with no imaging findings of recurrence or metastasis 24 months following surgery. Introduction Sclerosing stromal tumor (SST) of the ovary is a rare benign tumor that has been classified as a sex cord‑stromal tumor and is predominantly observed in young women (1,2). SSTs account for 1.5% of all ovarian tumors (1). The tumor usually occurs in the second and third decades of life (mean age, 21 years). The most common presenting symptoms are menstrual irregularity, abdominal pain and a lower abdominal mass (1,2). Microscopically, the tumor is characterized by pseudo-lobulation of cellular areas, marked vascularity and significant variation in cellular size and shape, and sclerosis is common (1,3). Surgical removal is curative and no local or distant recurrences have been reported following surgery (2,3). To the best of our knowledge, there have been numerous reports regarding the microscopic, ultrastructural and immunohistochemical, but not imaging, findings associated with

Correspondence to: Mr. Jingtao Wu, Department of Radiology, Subei People's Hospital of Jiangsu Province, Medical School of Yangzhou University, 98  Nantong West Road, Yangzhou, Jiangsu 225001, P.R. China E‑mail: [email protected]

Key words: ovary, sclerosing stromal tumor, computed tomography

this tumor  (3). The present study describes the computed tomography (CT) findings of 2 patients with ovarian SST, and confirms the correlation between imaging and pathological findings, as well as the reliability of imaging in preoperative characterization. The study was approved by the Ethics Committee of Subei People's Hospital of Jiangsu Province (Yangzhou, China) and the patients provided written informed consent for the publication of the present study. Case report Case 1. An 18‑year‑old Chinese female patient was admitted to Subei People's Hospital of Jiangsu Province in July 2012 with menstrual irregularities for 6 months. The blood test results for blood cell count, biochemistry and tumor markers, including cancer antigen (CA)19‑9 (3.57 KU/l; normal range,

CT findings of sclerosing stromal tumor of the ovary: A report of two cases and review of the literature.

Sclerosing stromal tumor (SST) of the ovary, which was first described by Chalvardjian and Scully in 1973, is a rare ovarian neoplasm, occurring predo...
605KB Sizes 0 Downloads 8 Views