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Creatine kinase and exercise Peter Griffiths Ann Clin Biochem published online 29 April 2014 DOI: 10.1177/0004563214531559 The online version of this article can be found at: http://acb.sagepub.com/content/early/2014/04/28/0004563214531559
Published by: http://www.sagepublications.com
On behalf of: Association for Clinical Biochemistry and Laboratory Medicine
Netherlands Society for Clinical Chemistry and Laboratory Japan Society of Clinical Chemistry
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Ann Clin Biochem OnlineFirst, published on April 29, 2014 as doi:10.1177/0004563214531559
Letter to the Editor Annals of Clinical Biochemistry 2014, Vol. 0(0) 1 acb.sagepub.com
Creatine kinase and exercise
Guarantor PG.
In their extensive review of changes in biomarkers following prolonged strenuous running,1 inter alia Bird et al. discuss creatine kinase (CK), and among the references quote Hoffman et al.,2 whose study of the Western States Endurance run was published in 2012. One of the earliest, if not the earliest similar study, was 50 years ago.3 Students from the London Medical Schools then competed in an annual London to Brighton run (53 miles). In the study, blood was collected at the start, approximately half way at Gatwick and from the survivors at Brighton, the latter showing an approximately 24-fold rise in CK with the assay used at that time. All the references in the review concerned with cardiac markers such as CK are post-2000. It poses an interesting question as to how far back in time, reviews in particular should go?
Contributorship PG is the sole author.
References 1. Bird SR, Linden M and Howley JA. Acute changes to biomarkers as a consequence of prolonged strenuous running. Ann Clin Biochem 2014; 51: 137–150. 2. Hoffman MD, Ingwerson JL, Rogers IR, et al. Increasing creatine kinase concentrations at the 161-km western states endurance run. Wilderness Environ Med 2012; 23: 56–60. 3. Griffiths PD. Serum levels of ATP:creatine phosphotransferase (creatine kinase). The normal range and effect of muscular activity. Clin Chim Acta 1966; 13: 413–420.
Peter Griffiths Broughty Ferry, Dundee, UK Email: [email protected]
Declaration of conflicting interests None declared.
Funding This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
! The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav acb.sagepub.com doi: 10.1177/0004563214531559 available online at http://acb.sagepub.com
Ethical approval Not applicable.
Downloaded from acb.sagepub.com at OhioLink on August 13, 2014
Creatine kinase and exercise Peter Griffiths Ann Clin Biochem published online 29 April 2014 DOI: 10.1177/0004563214531559 The online version of this article can be found at: http://acb.sagepub.com/content/early/2014/04/28/0004563214531559
Published by: http://www.sagepublications.com
On behalf of: Association for Clinical Biochemistry and Laboratory Medicine
Netherlands Society for Clinical Chemistry and Laboratory Japan Society of Clinical Chemistry
Additional services and information for Annals of Clinical Biochemistry: An international journal of biochemistry and laboratory medicine can be found at: Email Alerts: http://acb.sagepub.com/cgi/alerts Subscriptions: http://acb.sagepub.com/subscriptions Reprints: http://www.sagepub.com/journalsReprints.nav Permissions: http://www.sagepub.com/journalsPermissions.nav
>> OnlineFirst Version of Record - Apr 29, 2014 What is This?
Downloaded from acb.sagepub.com at OhioLink on August 13, 2014
XML Template (2014) [15.4.2014–3:00pm] //blrnas3/cenpro/ApplicationFiles/Journals/SAGE/3B2/ACBJ/Vol00000/140038/APPFile/SG-ACBJ140038.3d
(ACB)
[1–1] [PREPRINTER stage]
Ann Clin Biochem OnlineFirst, published on April 29, 2014 as doi:10.1177/0004563214531559
Letter to the Editor Annals of Clinical Biochemistry 2014, Vol. 0(0) 1 acb.sagepub.com
Creatine kinase and exercise
Guarantor PG.
In their extensive review of changes in biomarkers following prolonged strenuous running,1 inter alia Bird et al. discuss creatine kinase (CK), and among the references quote Hoffman et al.,2 whose study of the Western States Endurance run was published in 2012. One of the earliest, if not the earliest similar study, was 50 years ago.3 Students from the London Medical Schools then competed in an annual London to Brighton run (53 miles). In the study, blood was collected at the start, approximately half way at Gatwick and from the survivors at Brighton, the latter showing an approximately 24-fold rise in CK with the assay used at that time. All the references in the review concerned with cardiac markers such as CK are post-2000. It poses an interesting question as to how far back in time, reviews in particular should go?
Contributorship PG is the sole author.
References 1. Bird SR, Linden M and Howley JA. Acute changes to biomarkers as a consequence of prolonged strenuous running. Ann Clin Biochem 2014; 51: 137–150. 2. Hoffman MD, Ingwerson JL, Rogers IR, et al. Increasing creatine kinase concentrations at the 161-km western states endurance run. Wilderness Environ Med 2012; 23: 56–60. 3. Griffiths PD. Serum levels of ATP:creatine phosphotransferase (creatine kinase). The normal range and effect of muscular activity. Clin Chim Acta 1966; 13: 413–420.
Peter Griffiths Broughty Ferry, Dundee, UK Email: [email protected]
Declaration of conflicting interests None declared.
Funding This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
! The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav acb.sagepub.com doi: 10.1177/0004563214531559 available online at http://acb.sagepub.com
Ethical approval Not applicable.
Downloaded from acb.sagepub.com at OhioLink on August 13, 2014
