ARTICLE IN PRESS
PREVET-3742; No. of Pages 1
Preventive Veterinary Medicine xxx (2015) xxx–xxx
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Letter to the Editor Coxiella burnetii seroprevalence
factors in dairy and mixed cattle farms from Ecuador. Prev. Vet. Med. (January), http://dx.doi.org/10.1016/j.prevetmed.2015.01.007. Field, P.R., Santiago, A., Chan, S.W., Patel, D.B., Dickeson, D., Mitchell, J.L., Devine, P.L., Murphy, A.M., 2002. Evaluation of a novel commercial enzyme-linked immunosorbent assay detecting Coxiella burnetii-speciﬁc immunoglobulin G for Q fever prevaccination screening and diagnosis. J. Clin. Microbiol. 40 (September (9)), 3526– 3529. Henning, K., Sting, R., 2002. Deﬁnitive ability of Stamp-staining, antigenELISA, PCR and cell culture for the detection of Coxiella burnetii. Berl. Munch. Tierarztl. Wochenschr. 115 (September–October (9–10)), 381–384. Majidzadeh, K., Mohseni, A., Soleimani, M., 2014. Construction and evaluation of a novel internal positive control (IPC) for detection of Coxiella burnetii by PCR. Jundishapur J. Microbiol. 7 (January (1)), e8849. Malou, N., Renvoise, A., Nappez, C., Raoult, D., 2012. Immuno-PCR for the early serological diagnosis of acute infectious diseases: the Q fever paradigm. Eur. J. Clin. Microbiol. Infect. Dis. 31 (August (8)), 1951–1960.
Dear Editor, The report on “Coxiella burnetii seroprevalence” is very interesting (Carbonero et al., 2015). Carbonero et al. (2015) noted that “the true prevalence of C. burnetii seropositivity in dairy and mixed cattle from Ecuador reached 12.6% (CI95% : 11.3–13.9%).” Indeed, Q fever is an important infection in veterinary medicine. The seroprevalence study might be useful in disease prevention and control. The diagnostic property of the serological test is an issue to be discussed. Henning and Sting (2002) reported that “the capture ELISA seems to be a very sensitive assay for the detection of C. burnetii but it has a lack in speciﬁcity.” False positive can be seen in several infections such as leptospirosis and legionellosis (Field et al., 2002). Also, Majidzadeh et al. (2014) recently reported that “current diagnostic phase I IgG cutoff to >1:1024 is not recommended due to increased false-negative ﬁndings (sensitivity