5027
J Physiol 594.17 (2016) pp 5027–5028
Erratum/Corrigendum
Expression of concern
The Journal of Physiology
With the agreement of the authors, the Editor-in-Chief and the publisher John Wiley & Sons, The Journal of Physiology is publishing four Expressions of Concern regarding four articles that appeared in The Journal between 2009 and 2014. The Journal was alerted to the strong resemblance of western blots in figures in each of these four articles to blots in other figures in the same article and/or in other articles. After investigation by journal staff and experts in the field and consultation with the authors, we could not rule out the possibility that the western blots had been duplicated. All the articles involved have overlapping authorship. The similarity of the western blots raises questions about the reliability of some of the data in the four articles. The authors, the Editor-in-Chief and the publisher considered each paper separately before agreeing that publication of an Expression of Concern for each paper was necessary. The Journal has asked the corresponding authors’ institution to investigate these cases. Souza Pauli LS, Ropelle EC, de Souza CT, Cintra DE, da Silva AS, de Almeida Rodrigues B, de Moura LP, Marinho R, de Oliveira V, Katashima CK, Pauli JR & Ropelle ER (2014). Exercise training decreases mitogen-activated protein kinase phosphatase-3 expression and suppresses hepatic gluconeogenesis in obese mice. J Physiol, 592(6), 1325–40. DOI: 10.1113/jphysiol.2013.264002. The blot used for beta-actin in Figure 3B appears to be repeated in the following articles/figures: Figure 5B labelled as alpha tubulin in the article: Chiarreotto-Ropelle EC, Pauli LS, Katashima CK, Pimentel GD, Picardi PK, Silva VR, de Souza CT, Prada PO, Cintra DE, Carvalheira JB, Ropelle ER & Pauli JR (2013). Acute exercise suppresses hypothalamic PTP1B protein level and improves insulin and leptin signaling in obese rats. Am J Physiol Endocrinol Metab. 305(5):E649–59. DOI: 10.1152/ajpendo.00272.2013. Figure 8H labelled as alpha tubulin in the article: Eduardo R. Ropelle, Marcelo B. Flores, Dennys E. Cintra, Guilherme Z. Rocha, Jos´e R. Pauli, Joseane Morari, Claudio T. de Souza, Juliana C. Moraes, Patr´ıcia O. Prada, Dioze Guadagnini, Rodrigo M. Marin, Alexandre G. Oliveira, Taize M. Augusto, Hernandes F. Carvalho, L´ıcio A. Velloso, Mario J. A. Saad & Jos´e B. C. Carvalheira (2010). IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKβ and ER stress inhibition. PLoS Biol. 8(8): e1000465. DOI: 10.1371/journal.pbio.1000465. Figure 2D labelled as beta tubulin in the article: ´ Flores MB, Rocha GZ, Damas-Souza DM, Osorio-Costa F, Dias MM, Ropelle ER, Camargo JA, de Carvalho RB, Carvalho HF, Saad MJ & Carvalheira JB (2012). Obesity-induced increase in tumor necrosis factor-α leads to development of colon cancer in mice. Gastroenterology. 143(3):741–53.e1-4. DOI:10.1053/j.gastro.2012.05.045. Figure 1 G labelled as the Tub antibody in the article: Prada PO, Quaresma PG, Caricilli AM, Santos AC, Guadagnini D, Morari J, Weissmann L, Ropelle ER, Carvalheira JB, Velloso LA & Saad MJ (2013).Tub has a key role in insulin and leptin signaling and action in vivo in hypothalamic nuclei. Diabetes. 62(1):137–48. DOI:10.2337/db11-1388. The other papers on which an Expression of Concern has been issued as a result of this investigation are: C 2016 The Authors. The Journal of Physiology C 2016 The Physiological Society
DOI: 10.1113/JP272726
5028
Erratum/Corrigendum
J Physiol 594.17
Eduardo R. Ropelle, Jos´e R. Pauli, Patr´ıcia Prada, Dennys E. Cintra, Guilherme Z. Rocha, Juliana C. Moraes, Marisa J. S. Frederico, Gabrielle da Luz, Ricardo A. Pinho, Jos´e B. C. Carvalheira, Licio A. Velloso, Mario A. Saad & Cl´audio T. De Souza (2009). Inhibition of hypothalamic Foxo1 expression reduced food intake in diet-induced obesity rats. J Physiol, 587(10), pp 2341–2351. DOI 10.1113/jphysiol.2009.170050. Eduardo R. Ropelle, Jos´e R. Pauli, Dennys E. Cintra, Marisa J. S. Frederico, Ricardo A. De Pinho, L´ıcio A. Velloso & Cl´audio T. De Souza (2009). Acute exercise modulates the Foxo1/PGC-1α pathway in the liver of diet-induced obesity rats. J Physiol. 587(9):2069–76. DOI: 10.1113/jphysiol.2008.164202. Claudio T. De Souza, MarisaJ.S.Frederico, Gabrielle da Luz, DennysE.Cintra, Eduardo R. Ropelle, Jose R.Pauli, and Lıcio A. Velloso(2010). Acute exercise reduces hepatic glucose production through inhibition of the Foxo1/HNF-4α pathway in insulin resistant mice. J Physiol 588.12, 2239–2253.
C 2016 The Authors. The Journal of Physiology C 2016 The Physiological Society
J Physiol 594.17 (2016) pp 5027–5028
Erratum/Corrigendum
Expression of concern
The Journal of Physiology
With the agreement of the authors, the Editor-in-Chief and the publisher John Wiley & Sons, The Journal of Physiology is publishing four Expressions of Concern regarding four articles that appeared in The Journal between 2009 and 2014. The Journal was alerted to the strong resemblance of western blots in figures in each of these four articles to blots in other figures in the same article and/or in other articles. After investigation by journal staff and experts in the field and consultation with the authors, we could not rule out the possibility that the western blots had been duplicated. All the articles involved have overlapping authorship. The similarity of the western blots raises questions about the reliability of some of the data in the four articles. The authors, the Editor-in-Chief and the publisher considered each paper separately before agreeing that publication of an Expression of Concern for each paper was necessary. The Journal has asked the corresponding authors’ institution to investigate these cases. Souza Pauli LS, Ropelle EC, de Souza CT, Cintra DE, da Silva AS, de Almeida Rodrigues B, de Moura LP, Marinho R, de Oliveira V, Katashima CK, Pauli JR & Ropelle ER (2014). Exercise training decreases mitogen-activated protein kinase phosphatase-3 expression and suppresses hepatic gluconeogenesis in obese mice. J Physiol, 592(6), 1325–40. DOI: 10.1113/jphysiol.2013.264002. The blot used for beta-actin in Figure 3B appears to be repeated in the following articles/figures: Figure 5B labelled as alpha tubulin in the article: Chiarreotto-Ropelle EC, Pauli LS, Katashima CK, Pimentel GD, Picardi PK, Silva VR, de Souza CT, Prada PO, Cintra DE, Carvalheira JB, Ropelle ER & Pauli JR (2013). Acute exercise suppresses hypothalamic PTP1B protein level and improves insulin and leptin signaling in obese rats. Am J Physiol Endocrinol Metab. 305(5):E649–59. DOI: 10.1152/ajpendo.00272.2013. Figure 8H labelled as alpha tubulin in the article: Eduardo R. Ropelle, Marcelo B. Flores, Dennys E. Cintra, Guilherme Z. Rocha, Jos´e R. Pauli, Joseane Morari, Claudio T. de Souza, Juliana C. Moraes, Patr´ıcia O. Prada, Dioze Guadagnini, Rodrigo M. Marin, Alexandre G. Oliveira, Taize M. Augusto, Hernandes F. Carvalho, L´ıcio A. Velloso, Mario J. A. Saad & Jos´e B. C. Carvalheira (2010). IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKβ and ER stress inhibition. PLoS Biol. 8(8): e1000465. DOI: 10.1371/journal.pbio.1000465. Figure 2D labelled as beta tubulin in the article: ´ Flores MB, Rocha GZ, Damas-Souza DM, Osorio-Costa F, Dias MM, Ropelle ER, Camargo JA, de Carvalho RB, Carvalho HF, Saad MJ & Carvalheira JB (2012). Obesity-induced increase in tumor necrosis factor-α leads to development of colon cancer in mice. Gastroenterology. 143(3):741–53.e1-4. DOI:10.1053/j.gastro.2012.05.045. Figure 1 G labelled as the Tub antibody in the article: Prada PO, Quaresma PG, Caricilli AM, Santos AC, Guadagnini D, Morari J, Weissmann L, Ropelle ER, Carvalheira JB, Velloso LA & Saad MJ (2013).Tub has a key role in insulin and leptin signaling and action in vivo in hypothalamic nuclei. Diabetes. 62(1):137–48. DOI:10.2337/db11-1388. The other papers on which an Expression of Concern has been issued as a result of this investigation are: C 2016 The Authors. The Journal of Physiology C 2016 The Physiological Society
DOI: 10.1113/JP272726
5028
Erratum/Corrigendum
J Physiol 594.17
Eduardo R. Ropelle, Jos´e R. Pauli, Patr´ıcia Prada, Dennys E. Cintra, Guilherme Z. Rocha, Juliana C. Moraes, Marisa J. S. Frederico, Gabrielle da Luz, Ricardo A. Pinho, Jos´e B. C. Carvalheira, Licio A. Velloso, Mario A. Saad & Cl´audio T. De Souza (2009). Inhibition of hypothalamic Foxo1 expression reduced food intake in diet-induced obesity rats. J Physiol, 587(10), pp 2341–2351. DOI 10.1113/jphysiol.2009.170050. Eduardo R. Ropelle, Jos´e R. Pauli, Dennys E. Cintra, Marisa J. S. Frederico, Ricardo A. De Pinho, L´ıcio A. Velloso & Cl´audio T. De Souza (2009). Acute exercise modulates the Foxo1/PGC-1α pathway in the liver of diet-induced obesity rats. J Physiol. 587(9):2069–76. DOI: 10.1113/jphysiol.2008.164202. Claudio T. De Souza, MarisaJ.S.Frederico, Gabrielle da Luz, DennysE.Cintra, Eduardo R. Ropelle, Jose R.Pauli, and Lıcio A. Velloso(2010). Acute exercise reduces hepatic glucose production through inhibition of the Foxo1/HNF-4α pathway in insulin resistant mice. J Physiol 588.12, 2239–2253.
C 2016 The Authors. The Journal of Physiology C 2016 The Physiological Society
