TOXICOLOGICAL SCIENCES, 145(1), 2015, 209–210 doi: 10.1093/toxsci/kfv065 Advance Access Publication Date: February 20, 2015 CORRIGENDUM

CORRIGENDUM

Ovarian Xenobiotic Biotransformation Enzymes Are Altered During Phosphoramide Mustard-Induced Ovotoxicity Jill A. Madden and Aileen F. Keating Toxicological Sciences 141(2), (2014), 441–452 doi:10.1093/toxsci/kfu146 In the final published version of this article, an incorrect table was supplied for Table 1. The correct Table 1 is shown below. TABLE 1. Effect of PM Exposure on Ovarian Expression of Drug Metabolism Genes 2d mRNA

4d mRNA Fold Change

Fold

Gene Name

Symbol

P-Value

P-Value

Change

ATP-binding cassette, subfamily B (MDR/TAP), member 1A

Abcb1a

.001770*

2.58

.001727*

2.19

ATP-binding cassette, subfamily B (MDR/TAP), member 1B

Abcb1b

.000727*

4.78

.022683*

4.2

ATP-binding cassette, subfamily B (MDR/TAP), member 4

Abcb4

.515728

.13

.371106

.15

ATP-binding cassette, subfamily C (CFTR/MRP), member 1

Abcc1

.219424

.37

.316561

2.18

Amiloride binding protein 1 (amine oxidase, copper-containing)

Abp1

.757141

.04

.483421

.23

Alcohol dehydrogenase 1 (class I)

Adh1

.477045

.4

.006091*

.87

Alcohol dehydrogenase 4 (class II), pi polypeptide

Adh4

.152026

.7

.218344

.13

Aryl hydrocarbon receptor

Ahr

.753902

.08

.116944

.22

Aminolevulinate, delta-, dehydratase

Alad

.326891

.24

.277063

.13

Aldehyde dehydrogenase 1 family, member A1

Aldh1a1

.244120

.8

.827029

.05

Arachidonate 15-lipoxygenase

Alox15

.569599

.18

.391079

.22

Arachidonate 5-lipoxygenase

Alox5

.086132†

.31

.776196

.02

Apolipoprotein E

Apoe

.801956

.13

.429921

.16

Aryl hydrocarbon receptor nuclear translocator

Arnt

.464792

.28

.000838*

.29

ArsA arsenite transporter, ATP-binding, homolog 1 (bacterial)

Asna1

.404698

.34

.820665

.01

Biliverdin reductase A

Blvra

.233480

.44

.044453*

.15

Biliverdin reductase B (flavin reductase (NADPH))

Blvrb

.251273

.44

.381607

.06

Carboxylesterase 1E

Ces1e

.718231

.05

.865172

.01

Carboxylesterase 2C

Ces2c

.620531

.41

.084619†

1.11

Carbohydrate (keratan sulfate Gal-6) sulfotransferase 1

Chst1

.096756†

1.16

.020954*

.79

Catechol-O-methyltransferase

Comt

.398608

.2

.205772

.1

Cytochrome b5 reductase 3

Cyb5r3

.425607

.22

.458036

.12

Cytochrome P450, family 17, subfamily a, polypeptide 1

Cyp17a1

.884331

.06

.579077

.29

Cytochrome P450, family 19, subfamily a, polypeptide 1

Cyp19a1

.721957

.57

.009580*

5.16

Cytochrome P450, family 1, subfamily a, polypeptide 1

Cyp1a1

.896459

.49

.045311*

4.21

Cytochrome P450, family 1, subfamily a, polypeptide 2

Cyp1a2

.758402

.04

.469265

.15

Cytochrome P450, family 1, subfamily b, polypeptide 1

Cyp1b1

.627825

.07

.209534

.28

(continued) C The Author 2015. Published by Oxford University Press on behalf of the Society of Toxicology. V

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TOXICOLOGICAL SCIENCES, 2015, Vol. 145, No. 1

TABLE 1. Continued 2d mRNA

4d mRNA Fold Change

Fold

Gene Name

Symbol

P-Value

P-Value

Change

Cytochrome P450, family 27, subfamily b, polypeptide 1

Cyp27b1

.738395

.16

.242247

.33

Cytochrome P450, family 2, subfamily b, polypeptide 15

Cyp2b15

.162908

.17

.447085

.12

Cytochrome P450, family 2, subfamily b, polypeptide 3

Cyp2b3

.219644

.24

.447085

.12

Cytochrome P450, family 2, subfamily c, polypeptide 13

Cyp2c13

.227206

.25

.447085

.12

Cytochrome P450, family 2, subfamily c, polypeptide 6

Cyp2c6

.162908

.17

.447085

.12

Cytochrome P450, family 2, subfamily c, polypeptide 7

Cyp2c7

.162908

.17

.447085

.12

Cytochrome P450, family 2, subfamily e, polypeptide 1

Cyp2e1

.381847

.41

.373096

.41

Cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1

Cyp3a23/3a1

.802079

.07

.508695

.18

Cytochrome P450, family 4, subfamily b, polypeptide 1

Cyp4b1

.516023

.16

.750040

.2

Epoxide hydrolase 1, microsomal

Ephx1

.027860*

.79

.005051*

2.3

Fatty acid amide hydrolase

Faah

.380459

.25

.662959

.06

Fructose-1,6-bisphosphatase 1

Fbp1

.466451

.15

.871058

.01

Glutamate decarboxylase 1

Gad1

.886822

.49

.413211

.39

Glutamate decarboxylase 2

Gad2

.665363

.09

.789988

.41

Glucokinase (hexokinase 4) regulator

Gckr

.088618†

.42

.858440

.06

Gamma-glutamyltransferase 1

Ggt1

.752264

.17

.004788*

2.04

Glucose phosphate isomerase

Gpi

.294319

.31

.038706*

.36

Glutathione peroxidase 1

Gpx1

.869443

.03

.004771*

.33

Glutathione peroxidase 2

Gpx2

.219087

1.31

.018002*

3.21

Glutathione peroxidase 3

Gpx3

.729575

.21

.737319

.08

Glutathione peroxidase 4

Gpx4

.901330

.01

.680852

.04

Glutathione peroxidase 5

Gpx5

.162908

.17

.447085

.12

Glutathione reductase

Gsr

.561476

.13

.730703

.03

Glutathione S-transferase A3

Gsta3

.420991

.2

.016163*

.53

Glutathione S-transferase alpha 4

Gsta4

.024743*

.17

.665382

.06

Glutathione S-transferase mu 1

Gstm1

.855854

.01

.075047†

.36

Glutathione S-transferase mu 2

Gstm2

.776357

.11

.113875

.15

Glutathione S-transferase mu 3

Gstm3

.390435

.13

.080435

.33

Glutathione S-transferase mu 4

Gstm4

.352415

.3

.571792

.04

Glutathione S-transferase, mu 5

Gstm5

.127434

.49

.094276†

.12

Glutathione S-transferase pi 1

Gstp1

.134856

.24

.112341

.23

Glutathione S-transferase theta 1

Gstt1

.200890

.52

.179217

.16

Hexokinase 2

Hk2

.687386

.4

.040470*

1.25

Hydroxysteroid (17-beta) dehydrogenase 1

Hsd17b1

.324950

1.24

.125804

1.02

Hydroxysteroid (17-beta) dehydrogenase 2

Hsd17b2

.736142

.02

.556826

.37

Hydroxysteroid (17-beta) dehydrogenase 3

Hsd17b3

.883893

.05

.550401

.14

Lactoperoxidase

Lpo

.796552

.03

.024280*

4.74

Myristoylated alanine rich protein kinase C substrate

Marcks

.118478

.97

.238536

.95

Microsomal glutathione S-transferase 1

Mgst1

.061609†

.5

.653062

.04

Microsomal glutathione S-transferase 2

Mgst2

.231552

.11

.292247

.14

Microsomal glutathione S-transferase 3

Mgst3

.193045

.29

.239300

.12

Myeloperoxidase

Mpo

.997143

.25

.086698†

.95

Metallothionein 3

Mt3

.608582

.05

.005018*

.63

Methylenetetrahydrofolate reductase (NAD(P)H)

Mthfr

.124965

.82

.270348

.31

N-acetyltransferase 1

Nat1

.905990

.06

.142410

.14

Nitric oxide synthase 2, inducible

Nos2

.222886

.89

.001160*

2.48

Nitric oxide synthase 3, endothelial cell

Nos3

.170235

1.19

.014383*

.82

NAD(P)H dehydrogenase, quinone 1

Nqo1

.007059*

.65

.022685*

.55

Pyruvate kinase, liver and RBC

Pklr

.505933

.34

.669517

.02

Pyruvate kinase, muscle

Pkm2

.715647

.29

.111852

.42

Paraoxonase 1

Pon1

.678326

.19

.068923†

1.41

Paraoxonase 2

Pon2

.617326

.16

.242572

.1

Paraoxonase 3

Pon3

.532167

.1

.013010*

.5

Swi/SNF related matrix associated, actin dependent

Smarcal1

.138214

.3

.361878

.11 .44

regulator of chromatin, subfamily a-like 1 Stannin

Snn

.613461

.16

.031465†

Steroid-5-alpha-reductase, alpha polypeptide 1

Srd5a1

.224372

.26

.391807

.17

Xanthine dehydrogenase

Xdh

.943939

.06

.107604

.4

Actin, beta

Actb

.188799

.4

.009471*

.26

Beta-2 microglobulin

B2m

.008660*

.54

.131953

.31

Hypoxanthine phosphoribosyltransferase 1

Hprt1

.447244

.07

.303827

.04

Lactate dehydrogenase A

Ldha

.847446

.17

.039697*

.59

Ribosomal protein, large, P1

Rplp1

.452646

.07

.322481

.03

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